A5029558196- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Photosynthetic Processes and Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- DNA Repair Mechanisms
- Microtubule and mitosis dynamics
- bioluminescence and chemiluminescence research
- Cancer-related molecular mechanisms research
- ATP Synthase and ATPases Research
The University of Texas Southwestern Medical Center
2022-2025
University of Iowa
2022
During development, cells make switch-like decisions to activate new gene programs specifying cell lineage. The mechanisms underlying these decisive choices remain unclear. Here, we show that the cardiovascular transcriptional coactivator myocardin (MYOCD) activates identity genes by concentration-dependent and formation of condensates. MYOCD forms such condensates at critical concentration thresholds achieved during smooth muscle cardiomyocyte differentiation. carboxyl-terminal disordered...
Faithful chromosome segregation into gametes depends on Spo11-induced DNA double-strand breaks (DSBs). These yield single-stranded 3′ tails upon resection to promote crossovers (COs). While early Mre11-dependent end is the predominant pathway in most organisms, Exo1 or Dna2/BLM can also contribute efficient processing of meiotic DSBs. Although its enzymatic activity has been thoroughly dissected, temporal dynamics underlying Spo11 have remained mostly elusive. We show that, Caenorhabditis...
During cardiovascular development, cells make switch-like decisions to activate the expression of new gene programs leading lineage specification. The mechanisms underlying these decisive choices remain unclear. Myocardin is a cardiomyocyte and smooth muscle cell specific transcriptional coactivator, which necessary important for activating genes. We show that activates lineage-specific by concentration-dependent formation nuclear condensates. By modeling natural changes in concentration...