A5043224710- Spinal Dysraphism and Malformations
- Spinal Cord Injury Research
- Spinal Fractures and Fixation Techniques
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- Fetal and Pediatric Neurological Disorders
- Meningioma and schwannoma management
- Family and Disability Support Research
- Hemoglobin structure and function
- Spinal Hematomas and Complications
- Pelvic and Acetabular Injuries
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Teratomas and Epidermoid Cysts
- Medical Imaging and Analysis
- Pregnancy-related medical research
- Genetics and Neurodevelopmental Disorders
- Congenital gastrointestinal and neural anomalies
- Scoliosis diagnosis and treatment
- Heme Oxygenase-1 and Carbon Monoxide
Chinese PLA General Hospital
2014-2024
Nankai University
2024
Chinese People's Liberation Army
2014-2022
Nantong University
2019-2020
Shangri-la Institute
2018
People's Liberation Army No. 150 Hospital
2016
Beijing Hua Xin Hospital
2012
Zhujiang Hospital
2011
Southern Medical University
2011
Chinese General Hospital College of Nursing and Liberal Arts
2011
Objective: Pathophysiology of spinal cord injury (SCI) causes primary and secondary effects leading to loss neuronal function. The aim the present study was investigate role rosmarinic acid (RA) in protection against SCI.Methods: experimental carried out male wistar rats categorized into three groups. Group I – sham operated rats; II SCI; III SCI followed by RA treatment (10 mg/kg). tissues after schedule were analyzed for oxidative stress status through determination reactive oxygen species...
Abstract Peripheral nerve injuries (PNI) can lead to mitochondrial dysfunction and energy depletion within the affected microenvironment. The objective is investigate potential of transplanting mitochondria reshape neural regeneration High‐purity functional with an intact structure are extracted from human umbilical cord‐derived mesenchymal stem cells (hUCMSCs) using Dounce homogenization combined ultracentrifugation. Results show that when hUCMSC‐derived (hUCMSC‐Mitos) cocultured Schwann...
Peripheral nerve injury poses a great threat to neurosurgery and limits the regenerative potential of sacral nerves in neurogenic bladder. It remains unknown whether electrical stimulation can facilitate regeneration addition modulate bladder function. The objective this study was utilise sacra crush with newly constructed electroconductive scaffold explore role macrophages crushed nerves. As result, we generated polypyrrole-coated polycaprolactone/silk fibroin through which applied...
Astrocytoma is one of the most common types brain tumor, which histologically and clinically classified into four grades (I-IV): I (pilocytic astrocytoma), II (diffuse III (anaplastic IV (glioblastoma multiforme). A higher grade astrocytoma represents a worse prognosis more aggressive. In this study, we compared differential proteome profile from to IV. The protein samples clinical specimens I, II, III, were analyzed by two-dimensional liquid chromatography-tandem mass spectrometry isobaric...
Tethered cord syndrome is a progressive disease with typically insidious onset in infants and children, which can lead to persistent progress of neurological deficits high rate disability without timely intervention. The purpose this study was investigate the curative effect microsurgery children different types tethered syndrome. In study, we analyzed 326 patients syndrome, aged from 2 months 14 years old, who were followed for 3-36 after microscopic surgery. Based on clinical...
Study Design. Retrospective case series. Objective. Anterior sacral meningocele (ASM) is a rare disorder. We reviewed 11 cases of congenital ASM and classified them into three types based on the anatomy relationship between cyst nerve roots. Summary Background Data. The cohort with relatively large; classification novel has not been previously reported. Methods. Eleven consecutive patients who underwent surgery February 2014 January 2019 were retrospectively analyzed. They included four...
Infantile spasms is an age-specific epileptic syndrome associated with poor developmental outcomes and response to nearly all traditional antiepileptic drugs except adrenocorticotropic hormone (ACTH). We investigated the protective mechanism of ACTH against brain damage. An infantile spasm rat model induced by N-methyl-d-aspartate (NMDA) in neonate rats was used. Pregnant were randomly divided into stress-exposed non-stress exposed groups, their offspring ACTH-treated model, untreated...
Abstract Spinal sacral nerve injury represents one of the most serious conditions associated with many diseases such as fracture, tethered cord syndrome and canal tumor. could cause bladder denervation detrusor underactivity. There is limited clinical experience resolving spinal underactivity patients, thus treatment options are also scarce. In this study, we established a animal model for deeper understanding further researching disease. Forty 8 w (week) old Sprague Dawley rats were...
This study aimed to explore the migration process of conus medullaris (CM) in early infancy using infant MRI and evaluate application for locating CM level.The authors retrospectively analyzed level on lumbosacral MR images 26 term infants aged < 3 months who were classified into three groups according age. The numbered each patient range average cohort. studied linear correlation between postnatal days with regression analysis, 1-way ANOVA, least significant difference test.The ranged from...
A large number of chemokines, cytokines, other trophic factors and the extracellular matrix molecules form a favorable microenvironment for peripheral nerve regeneration. This is one major regenerative success. Therefore, it important to investigate key regulators affecting regeneration after injury. However, identities specific cytokines at various time points sciatic injury have not been determined. The study was performed by transecting establish model analyze, protein microarray,...
Introduction Observational studies have yielded inconsistent findings regarding the correlation between bone mineral density (BMD) and various spinal disorders. To explore relationship total-body BMD disorders further, we conducted a Mendelian randomization analysis to assess this association. Methods Two-sample bidirectional (MR) was employed investigate association The inverse-variance weighted (IVW) method used as primary effect estimate, additional methods, including median, MR-Egger,...