A5103276534- Cancer Treatment and Pharmacology
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Head and Neck Surgical Oncology
- Oral and Maxillofacial Pathology
- Corneal surgery and disorders
- Neutropenia and Cancer Infections
- Nanoparticle-Based Drug Delivery
- HER2/EGFR in Cancer Research
- Ocular Surface and Contact Lens
- Breast Cancer Treatment Studies
- Ophthalmology and Visual Impairment Studies
- Glaucoma and retinal disorders
- Bone Tumor Diagnosis and Treatments
- Retinal Imaging and Analysis
- Bipolar Disorder and Treatment
- Colorectal Cancer Treatments and Studies
- Multiple Myeloma Research and Treatments
- Systemic Lupus Erythematosus Research
- Prostate Cancer Treatment and Research
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Testicular diseases and treatments
- Ovarian cancer diagnosis and treatment
- Ocular Diseases and Behçet’s Syndrome
Lilavati Hospital & Research Centre
2024
Wills Eye Hospital
2023
University of North Carolina at Charlotte
2023
Intas Pharmaceuticals (India)
2016-2022
Command Hospital Air Force
2017-2021
Liaquat University of Medical & Health Sciences
2021
Command Hospital
2018
Armed Forces Medical College
2016-2017
Walsall Manor Hospital
2012
Government Dental College & Research Institute
2011
<b><i>Background:</i></b> This subgroup analysis of the RE-ENACT study evaluates effectiveness Razumab® (the world’s first biosimilar ranibizumab by Intas Pharmaceuticals Ltd.) in Indian patients with retinal vein occlusion (RVO). <b><i>Methods:</i></b> The data on RVO who had received ≥3 injections between January and August 2016 were analyzed. Endpoints were: improvement best corrected visual acuity (BCVA), a decrease central macular...
The REal life assessmENt of safety And effeCTiveness Razumab (RE-ENACT) and long-term RE-ENACT 2 retrospective studies have evaluated the use Razumab™ (world's first biosimilar ranibizumab) in retinal disorders Indian patients. This report presents subgroup analysis from study patients with wet age-related macular degeneration (wet AMD).Medical charts administered ranibizumab injections as PRN treatment regimen between September 2015 June 2018, at 17 centers across India, were reviewed....
Endoxifen is a protein kinase C inhibitor. The objective of the present phase III study was to demonstrate safety and efficacy endoxifen in treating bipolar I disorder (BPD I) patients.A multicenter, double-blind, active-controlled conducted using daily dose 8 mg compared 1000 divalproex, current standard treatment, patients with BPD acute manic episodes with/without mixed features. primary endpoint our mean change total Young Mania Rating Scale (YMRS) score at day 21.Endoxifen (n = 116)...
An abstract is not available for this content so a preview has been provided. Please use the Get access link above information on how to content.
The REal life assessmENt of safety And effeCTiveness Razumab 2 (RE-ENACT 2) study evaluated the long-term effectiveness biosimilar ranibizumab. We present subgroup analysis patients with retinal vein occlusion (RVO).Data who received pro re nata (PRN) ranibizumab (November 2015 to December 2018, 17 centers) were analyzed. Endpoints change from baseline in best corrected visual acuity (BCVA, Snellen's/logMAR), central subfield thickness (CSFT), intraocular pressure (IOP), and proportions...
The management of breast cancer with advanced disease or metastasis is a common problem in India and other countries. A panel 13 oncology experts deliberated on the sidelines 35th Indian Cooperative Oncology Network Conference held Mumbai to formulate an expert opinion recommendation novel drug delivery system (NDDS) formulations treatment metastatic (MBC). survey comprised 39 questions related limitations conventional therapeutic positioning NDDS docetaxel, paclitaxel doxorubicin MBC. used...
Docetaxel has been widely used in the treatment of several cancers, including adenocarcinoma prostate gland. As docetaxel is insoluble water, it must be administered with polysorbate 80 and ethanol, which are known to cause hypersensitivity reactions. Premedication corticosteroids antihistamines advocated prior administration; however, toxicities, occasionally fatal, have reported, even corticosteroid premedication. We herein report case a patient prostate, bone metastasis an Eastern...
The standard of care for locally advanced cervical cancer has been the combination a taxane with platinum based therapy. Conventional docetaxel is known to cause hypersensitivity reactions, fluid retention and other toxicities due polysorbate-80 ethanol. Corticosteroid premedication prior administration required prevent these toxicities, however, are still observed, sometimes fatal, despite premedication. DoceAqualip, nanosomal lipid suspension, developed lipids generally regarded as safe...
Squamous cell carcinoma (SCC) of the pancreas is a rare tumor with only few case reports available. It an aggressive form pancreatic cancer poor prognosis. The diagnosis and optimal management SCC poorly defined due to lack standard treatment or guidelines owing rarity this malignancy. Patients suffering from do not respond well chemotherapy radiotherapy isolated are available on use gemcitabine newer taxane formulations. Surgical resection most effective modality; however, delay in...
To evaluate the bioequivalence of a hybrid pegylated liposomal doxorubicin (PLD) hydrochloride injection with reference product Caelyx®. This multicenter, open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, study was conducted in female patients aged ≥18 years and ≤75 ovarian cancer, whose disease progressed or recurred after platinum-based chemotherapy, who were scheduled to start PLD therapy. Patients intravenously infused drugs over 1 h at 50...
Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) are linked to the global epidemic, leading increased progression adverse health outcomes. The renaming of NAFLD metabolic dysfunction-associated steatotic (MASLD) at 2023 European Association for Study Liver Congress highlights complex relationship between disorders health. Taking this into consideration, we aimed study identify prevalence risk factors associated with stages in individuals T2DM Indian population.
Abstract Objective Antihyperglycemic activity of Thymoquinone (TQ) was evaluated in diabetic mouse model and patients. Methods TQ (50 mg/kg) orally administered daily for 21 days combination with metformin mice a reduction on blood glucose level monitored. In human, 90-day randomized study carried out 60 Type 2 Diabetes mellitus patients to evaluate safety efficacy administration 3-arm study. Patients arm 1 (T1) received tablet SR 1000 mg 50 once daily. The second (T2) tablets 3 (R) only....
A 45-year-old man was admitted with a 4 day history of right facial pain and on examination, there atrophy the side tongue. Magnetic resonance angiography demonstrated carotid artery dissection aspirin commenced.
The purpose of this study was to evaluate the efficacy and safety nanosomal docetaxel lipid suspension (NDLS, DoceAqualip)-based chemotherapy in breast cancer.Medical charts patients with cancer, who were treated followed up NDLS (75-100 mg/m2; 3-week cycle)-based from August 2014 to September 2018, analyzed multicenter, retrospective study. endpoints overall response rate (ORR: complete [CR]+partial [PR]) disease control (DCR: CR+PR+stable [SD]) neoadjuvant metastatic settings. Overall...
Neurofibroma is a benign peripheral nerve sheath tumor.It one of the most frequent tumors neural origin and its presence clinical criteria for diagnosis neurofibromatosis type I (NF-I).Neurofibromatosis an autosomal dominantly inherited disease due to alteration in long arm chromosome 17.About 50% NF-I patients have no family history disease.NF-I skin lesions (café au lait spots neurofibromas) as well bone malformations central nervous system tumors.Diagnosis based on series criteria.NF-I...
Abstract: The current report presents a case of pregnant woman with breast cancer metastasized to liver and lungs. standard care for in pregnancy is anthracycline/taxane-based chemotherapy regimens. Docetaxel has shown favorable toxicity profile during the second third trimesters pregnancy. A novel nanosomal docetaxel lipid suspension (NDLS) (DoceAqualip), proven efficacy tolerability profile, been approved India treatment advanced solid tumors since 2013. We present here metastatic managed...