A5011546859- Hippo pathway signaling and YAP/TAZ
- Liver physiology and pathology
- Lipid metabolism and biosynthesis
- Dialysis and Renal Disease Management
- Cellular Mechanics and Interactions
- Renal and related cancers
- FOXO transcription factor regulation
- Phagocytosis and Immune Regulation
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- 3D Printing in Biomedical Research
- Esophageal and GI Pathology
Sapienza University of Rome
2016-2023
Istituto Pasteur
2019
Policlinico Umberto I
2018
In many cell types, several cellular processes, such as differentiation of stem/precursor cells, maintenance differentiated phenotype, motility, adhesion, growth, and survival, strictly depend on the stiffness extracellular matrix that, in vivo , characterizes their correspondent organ tissue. liver, stromal rigidity is essential to obtain correct physiology whereas any alteration causes liver dysfunctions. The substrate an element no longer negligible for cultivation so that data far...
Yes-associated protein (YAP) is a transcriptional co-factor involved in many cell processes, including development, proliferation, stemness, differentiation, and tumorigenesis. It has been described as sensor of mechanical biochemical stimuli that enables cells to integrate environmental signals. Although the liver correlation between extracellular matrix elasticity (greatly increased most chronic hepatic diseases), differentiation/functional state parenchymal subcellular...
Abstract YES-associated protein (YAP) is a transcriptional cofactor with key role in the regulation of several physio-pathological cellular processes, by integrating multiple cell autonomous and microenvironmental cues. YAP main downstream effector Hippo pathway, tumor-suppressive signaling able to transduce extracellular signals. The pathway acts restraining activity, since its activation induces phosphorylation cytoplasmic sequestration. However, recent observations indicate that activity...
Abstract Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in variety conditions including dialysis (PD), post-surgery adhesions and metastases. The acquisition invasive pro-fibrotic abilities by mesothelial cells (MCs) through induction MMT, cell-specific form EMT, plays main role this process. Aim study was to evaluate possible effects histone deacetylase (HDAC) inhibitors, key components epigenetic machinery, counteracting MMT observed MCs isolated from...
Nonalcoholic steatohepatitis (NASH) is the critical stage of nonalcoholic fatty liver disease (NAFLD). The persistence necroinflammatory lesions and fibrogenesis in NASH leading cause cirrhosis and, ultimately, hepatocellular carcinoma. To date, histological examination biopsies, albeit invasive, remains means to distinguish from simple steatosis (NAFL). Therefore, a noninvasive diagnosis by serum biomarkers eagerly needed. Here, proteomic approach, we analysed soluble low-molecular-weight...
The cytokine transforming growth factor β (TGFβ) plays a crucial role in the induction of both epithelial-to-mesenchymal transition (EMT) program and fibro-cirrhotic process liver, where it contributes also to organ inflammation following several chronic injuries. All these pathological situations greatly increase risk hepatocellular carcinoma (HCC) contribute tumor progression. In particular, late-stage HCCs are characterized by constitutive activation TGFβ pathway an EMT molecular...
Abstract YES-associated protein (YAP) is a transcriptional cofactor with key role in the regulation of several cellular processes, including proliferation, differentiation and epithelial-to-mesenchymal transition (EMT), by integrating multiple cell autonomous microenvironmental cues. YAP overexpression was found different types human cancer where it associated acquisition stemness properties, chemoresistance, increased proliferation survival, metastasis and, ultimately, poor prognosis. main...