A5048255683- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Antimicrobial Peptides and Activities
- Colorectal and Anal Carcinomas
- Health Systems, Economic Evaluations, Quality of Life
- Vector-borne infectious diseases
- Hidradenitis Suppurativa and Treatments
- Contact Dermatitis and Allergies
- Viral Infections and Vectors
- Antifungal resistance and susceptibility
- Probiotics and Fermented Foods
- Photoacoustic and Ultrasonic Imaging
- Inflammatory mediators and NSAID effects
- Spaceflight effects on biology
- Protease and Inhibitor Mechanisms
- Bacterial Identification and Susceptibility Testing
- Hair Growth and Disorders
- Legionella and Acanthamoeba research
- Food Allergy and Anaphylaxis Research
- Patient Satisfaction in Healthcare
- Pregnancy and Medication Impact
University of Miami
2024-2025
University of Cincinnati
2019-2023
Cincinnati Children's Hospital Medical Center
2017-2020
University of Cincinnati Medical Center
2020
University of North Dakota
2013-2015
Atopic dermatitis (AD) patients are often colonized with Staphylococcus aureus, and staphylococcal biofilms have been reported on adult AD skin lesions. The commensal S epidermidis can antagonize although its role in is unclear. We sought to characterize aureus colonization biofilm propensity determine their associations severity, barrier function, epidermal gene expression the first US early-life cohort of children AD, Mechanisms Progression Dermatitis Asthma Children (MPAACH).The isolates...
Hidradenitis Suppurativa (HS) is a debilitating condition marked by painful nodules and abscesses, progressing to sinus tracts (tunnels) within the skin's dermal layers, causing significant discomfort, foul-smelling discharge, disfigurement, contractures, scarring, which severely diminish quality of life. HS associated with alterations in skin microbiome, impacting immune regulation defense against harmful bacteria. Despite its prevalence, contribution microbiome disease pathology limited...
The causative agent of Lyme disease, Borrelia burgdorferi, codes for several known fibronectin-binding proteins. Fibronectin a common the target diverse bacterial pathogens, and has been shown to be essential in allowing development certain disease states. Another borrelial protein, BB0347, sequence similarity with these other proteins, may important pathogenesis. Herein, we perform an initial characterization BB0347 via use molecular biochemical techniques. We found that is expressed,...
Abstract Intracellular pathogens including Staphylococcus aureus contribute to the non‐healing phenotype of chronic wounds. Lactobacilli, well known as beneficial bacteria, are also reported modulate immune system, yet their role in cutaneous immunity remains largely unknown. We explored therapeutic potential bacteria‐free postbiotics, bioactive lysates lactobacilli, reduce intracellular S. colonization and promote healing. Fourteen postbiotics derived from various lactobacilli species were...
ABSTRACT Previous studies indicated that the Lyme disease spirochete Borrelia burgdorferi expresses RevA outer surface protein during mammalian infection. As an adhesin promotes bacterial interaction with fibronectin, appears to be a good target for preventive therapies. proteins are highly conserved across all borreliae, and antibodies against cross-reactive among from diverse strains. Mice infected B. mounted rapid IgM response RevA, followed by strong IgG generally remained elevated more...
Abstract Infective endocarditis (IE) is associated with high morbidity and mortality rates. The predominant bacteria causing IE Staphylococcus aureus ( S. ), which can bind to existing thrombi on heart valves generate vegetations (biofilms). In this in vitro flow study, we evaluated sonobactericide as a novel strategy treat IE, using ultrasound an contrast agent or without other therapeutics. We developed model of biofilm human whole-blood clots infected patient-derived (infected clots)....
Escherichia coli lipoprotein (Lpp) is a major cellular component that exists in two distinct states, bound-form and free-form. Bound-form Lpp known to interact with the periplasmic bacterial cell wall, while free-form localized surface. A function for surface-exposed has yet be determined. We hypothesized presence of C-terminal lysinses region would facilitate binding host zymogen plasminogen (Plg), protease commandeered by number clinically important bacteria. Recombinant was synthesized...
Hispanic/Latino populations are more likely to have extensive psoriasis than the non-Hispanic/Latino population. Biologics indicated for moderate/severe or with comorbidities. No studies assessed ethnicity as a predictor of biologic utilization. We aimed determine if utilization differs between Latinos and non-Latinos psoriasis.This study utilizes data from National Ambulatory Medical Care Survey (NAMCS) 2003 2016. Psoriasis visits were selected by International Classification Diseases,...