A5024113302- Dendrimers and Hyperbranched Polymers
- Chemical Synthesis and Analysis
- Plant biochemistry and biosynthesis
- Advanced Chemical Sensor Technologies
- Essential Oils and Antimicrobial Activity
- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- RNA Interference and Gene Delivery
- Catalytic Cross-Coupling Reactions
- Click Chemistry and Applications
- Plant Physiology and Cultivation Studies
- Catalytic Alkyne Reactions
- Meat and Animal Product Quality
- Molecular Junctions and Nanostructures
- Protein Structure and Dynamics
- Animal Nutrition and Physiology
- Ferrocene Chemistry and Applications
- Phytochemicals and Antioxidant Activities
- Biochemical Analysis and Sensing Techniques
- Traditional and Medicinal Uses of Annonaceae
- Mass Spectrometry Techniques and Applications
- Cyclopropane Reaction Mechanisms
- Advanced biosensing and bioanalysis techniques
- African Botany and Ecology Studies
- Banana Cultivation and Research
Firmenich (Switzerland)
2008-2018
University of Bern
2003-2007
Centre National de la Recherche Scientifique
2003
Université de Strasbourg
2003
The contribution of the dendritic structure in catalysis ester hydrolysis was investigated with a systematic peptide dendrimer series increasing generation number (G1-G4) containing catalytic consensus sequence His-Ser all branches. A strong positive effect observed up to 100-fold increased histidine reactivity between G1 and G4. Kinetic studies isothermal calorimetric titration experiments showed that resulted from cooperativity binding catalysis.
Enzymelike kinetics were observed in the hydrolysis of 7-hydroxy-1-methylquinolium esters 2 under catalysis three a family synthetic peptide dendrimers 1. Their synthesis was based on symmetrical branching diamino acid (B), variable amino positions (A1, A2, A3=His, Asp, Ser), and disulfide bond dimerization strategy. All possible permutations catalytic triad acids aspartate, histidine, serine at gave 21 dendrimers. Supporting information for this article is available WWW...
Peptide dendrimers built by iteration of the diamino acid dendron Dap-His-Ser (His = histidine, Ser Serine, Dap propionic acid) display a strong positive dendritic effect for catalytic hydrolysis 8-acyloxypyrene 1,3,6-trisulfonates, which proceeds with enzyme-like kinetics in aqueous medium (Delort, E.; Darbre, T.; Reymond, J.-L. J. Am. Chem. Soc. 2004, 126, 15642-3). Thirty-two mutants original third generation dendrimer A3 ((Ac-His-Ser)8(Dap-His-Ser)4(Dap-His-Ser)2Dap-His-Ser-NH2) were...
Catalytic esterase peptide dendrimers with a core active site were discovered by functional screening of 65 536-member combinatorial library third-generation using fluorogenic 1-acyloxypyrene-3,6,8-trisulfonates as substrates. In the best catalyst, RMG3, ((AcTyrThr)8(DapTrpGly)4(DapArgSerGly)2DapHisSerNH2), ester hydrolysis is catalyzed single catalytic histidine residue at dendrimer core. A pair arginine residues in first-generation branch assists substrate binding. The proficiency RMG3...
Abstract Peptide dendrimers were prepared by solid‐phase peptide synthesis. Monomeric first obtained assembly of a hexapeptide sequence containing alternate standard α ‐amino acids with diamino as branching units. The monomeric then dimerized disulfide‐bridge formation at the core cysteine. synthetic strategy is compatible functional amino and different acid composed catalytic triad histidine, aspartate, serine catalyzed hydrolysis N ‐methylquinolinium salts when histidine residues placed...
Abstract The volatile constituents of the peel solvent extract Australian finger lime Citrus australasica were analysed by GC–MS. Besides limonene, isomenthone was a major component, which is rare in species. Six new terpenyl esters also identified and confirmed chemical synthesis: citronellyl 2‐methylbutanoate; 1,8(10)‐ p ‐menthadien‐9‐yl propanoate; 3‐methylbutanoate; 1‐ ‐menthen‐9‐yl 3‐methylbutanoate. To best our knowledge, last four compounds have never before been natural product...
Several bicyclic compounds bearing a 1,2-cyclopentanediol have been prepared from various anti- or syn-gamma-bromopropargylic diols and cis-dioxolanes under palladium(0) catalysis. The reaction proceeds through 5-exo-dig cyclocarbopalladation. When the corresponding trans-dioxolanes are used, only products isolated obtained direct Stille cross-coupling reaction. [reaction: see text]
Oyster leaf (Mertensia maritima), also called vegetarian oyster, has a surprising oyster-like aroma. Its volatile composition was investigated here for the first time. In total, 109 compounds were identified by gas chromatography-mass spectrometry (GC-MS) and quantified GC-FID. The use of GC-olfactometry on both polar nonpolar columns allowed detection molecules having an oyster-like, marine odor. Four confirmed synthesis: (Z)-3-nonenal, (Z)-1,5-octadien-3-ol, (Z,Z)-3,6-nonadienal,...
Abstract The volatile compounds from cooked petai beans ( Parkia speciosa ) were isolated by hydrodistillation under reduced pressure followed solvent extraction. organic extract was analyzed classical single quadrupole GC/MS and high resolution GC/ToF‐MS. Cyclic polysulphides the major components of petai. New sulphur minor also identified some them synthesised. 1,3‐Dithiabutane found for first time in a natural product whereas 2,4‐dithiapentane, 2,3,5‐trithiahexane 2,4,6‐trithiaheptane ....
Abstract Citrus cold pressed oils are of great importance to the flavour and fragrance industry. Because their high added value, careful attention must be paid ensure oils' genuineness authenticity. Characterising chemical complexity in a holistic perspective constitutes potent way relate specific compounds organoleptic properties interest assess quality. In this context, complete characterisation using untargeted metabolomics represents an analytical challenge. The present study takes...
Wie Enzyme katalysieren drei Dendrimere aus einer Familie synthetischer Peptid-Dendrimere 1 die Hydrolyse des 7-Hydroxy-1-methylchinonesters 2. Die Synthese dieser Katalysatoren erfolgte ausgehend von symmetrisch verzweigten Diaminosäuren (B) durch Umsetzung mit variierenden Aminosäuren (A1, A2, A3=His, Asp, Ser) und Dimerisierung zu einem Disulfid. Unter Ausschöpfung aller Kombinationsmöglichkeiten der verwendeten Aspartat, Histidin Serin erhält man Zugang 21 Peptid-Dendrimeren. Supporting...
Several chicken parts (skin, fat, juice) were cooked in different ways (roasting, simmering) and investigated separately for their volatile composition. In-depth GC/MS analysis of the separate fractions revealed several unknown molecules. Mass spectra interpretation allowed us to identify nine molecules first time chicken, including cyclic aldehydes, ketones, new δ-lactones containing an unsaturated linear chain. Identification was confirmed by chemical synthesis followed comparison mass...
Peptide dendrimers composed of alternating sequences natural amino acids and branching diamino are investigated as synthetic enzyme models. The can be prepared by solid-phase peptide synthesis obtained pure in yields 5–35%. with surface histidine residues catalyze ester hydrolysis reaction enzyme-like kinetics, including substrate binding (KM), catalytic turnover (kcat), rate acceleration kcat/kuncat = 1000–20'000. Mechanistic investigation variation, pH-profile, isothermaltitration...
Abstract Peptide dendrimers assembled by solid‐phase peptide synthesis using a branching diamino acid at every 2 nd or 3 rd position provide readily accessible synthetic model systems for proteins and enzymes. They adopt globular shape topology rather than folding. of generation functionalized with cysteine cystine residue in the core were adsorbed on Au(111) surface imaged STM air, under UHV, solution. The appear as features dimensions suggesting an extended flattened conformation, forming...
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