A5007405393- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Anesthesia and Neurotoxicity Research
- Molecular Communication and Nanonetworks
Korean Association Of Science and Technology Studies
2022-2024
Korea Institute of Science and Technology
2022-2024
Korea Institute of Brain Science
2022-2024
Boramae Medical Center
2022-2023
Seoul National University
2023
Korea Research Institute of Chemical Technology
2022
Yonsei University
2020
Abstract Continuous recording of intracellular activities in single cells is required for deciphering rare, dynamic and heterogeneous cell responses, which are missed by population or brief single-cell recording. Even if the field constantly proceeding, several technical challenges still remained to conquer this important approach. Here, we demonstrate long-term combining a vertical nanowire multi electrode array (VNMEA) with optogenetic stimulation minimally disrupt survival functions...
TREK-1 (TWIK-related potassium channel-1) is a subunit of the two-pore domain (K2p) channel and widely expressed in brain. knockout mice were shown to have antidepressant-like effects, providing evidence for channel's potential as therapeutic target. However, currently there no good pharmacological inhibitor specifically targeting containing K2p channels that also displays similar effects. Here, we sought find selective potent inhibitors related dimers both vitro vivo. We synthesized...
Background and Purpose: TREK-1 (TWIK-related potassium channel-1) is a subunit of the two-pore domain (K2p) channel widely expressed in brain. knockout mice were shown to have antidepressant-like effects, providing evidence for channel’s potential as therapeutic target. However, currently there no good pharmacological inhibitor specifically targeting containing K2p channels that also displays similar effects. Experimental Approach: We sought find selective potent inhibitors related dimers...