The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) provides uniform diagnostic terminology communication between pathologists and clinicians. Each category is associated with a specific risk of malignancy recommendation its management. indeterminate categories atypia undetermined significance/follicular lesion significance (AUS/FLUS) present major challenge both We report our institution's 3 years' experience the AUS/FLUS follow-up these patients.A retrospective analysis was...

We investigated the anti-inflammatory and immunomodulatory effect of simvastatin on articular cartilage via inhibition matrix metalloproteinase-3 (MMP-3), a matrix-degrading enzyme, in mechanically induced experimental osteoarthritis (OA) animal model.Twenty-seven albino Wistar rats were divided three groups equal number. Unphysiologic loading was simulated by transecting anterior cruciate ligaments right knees 18 consisting 1 2. Nine animals group 2 received orally administered 20 mg/kg per...

Abstract Purpose To compare the antifungal efficacy of corneal collagen cross‐linking with photoactivated riboflavin ( PACK ‐ CXL ) and voriconazole in experimental Fusarium solani Candida albicans keratitis models. Methods Sixty‐four corneas 32 New Zealand rabbits were included divided into two main groups. Intrastromal injection suspensions was performed, it observed that formed on third day. Both groups randomly separated following four groups: control, , combined voriconazole. applied...

Abstract Background The aim of the present study was to investigate effects chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) on bladder function and pathophysiology. Methods To create a model for CPPS, rats were intraprostatically injected with zymosan or saline, serving as control. Metabolic cage experiments performed 7, 14, 21 days after injection 14 in control group. Thereafter, cystometry which simulated micturition cycles induced by saline infusion contractile responses...

Near infrared spectroscopy measures tissue oxygenation even when there is complete cessation of blood flow. We evaluated near to diagnose testicular torsion and blindly compared its accuracy with that Doppler ultrasound. also it by immunohistochemical evaluation hypoxia cell viability.Rats were randomized 4 groups, including group 1-720-degree unilateral torsion, 2-360-degree 4-sham operation 4-720-degree followed surgical reduction at minute 180. ultrasound done minutes 0, 5, 30, 60, 180...

The aim of the study was to investigate expression and methylation status seven distinctive genes with tumor suppressing properties in childhood adolescent lymphomas. A total 96 patients Hodgkin Lymphoma (HL, n = 41), Non-Hodgkin (NHL, 15), reactive lymphoid hyperplasia (RLH, 40, as controls) are included research. CDKN2A, SPI1, PRDX2, DLEC1, FOXO1, KLF4 DAPK1 were measured QPCR method after RNA isolation from paraffin blocks tissue cDNA conversion. DNA performed samples low gene followed by...

Introduction: The aim of this study was to compare the diagnostic adequacy thyroid samples obtained by aspiration or capillary biopsy techniques, with 22 27 gauge needles, and without onsite cytological analysis (OCA). Material methods: Four hundred patients nodules underwent ultrasound (US)-guided fine-needle biopsies. Patients were divided into eight groups according needle size (22 vs. gauge), technique (aspiration capillary), whether not OCA performed. Sample rates calculated for each...

The World Health Organization (WHO) proposed an updated reporting system for pancreaticobiliary cytology, which moves low-grade malignancies to "positive malignancy" group and serous cystadenoma "negative group. WHO also created two new categories, namely, pancreatic neoplasia-low grade (PaN-Low) neoplasia-high (PaN-High), includes neoplastic mucinous cysts stratifies them according their cytologic atypia. risk of malignancy (ROM) the categories needs be defined.

Chronic pelvic pain syndrome (CPPS) is a common and bothersome condition for which no pharmacological treatment options with acceptable efficacy exist. The aim of this study was to investigate the effects soluble guanylate cyclase (sGC) activator BAY 60-2770 COX-2 inhibitor celecoxib on bladder function in rat model CPPS.Forty-eight male Sprague-Dawley rats were intraprostatically injected either saline, serving as control, or zymosan, induce prostatitis. On days 8-20, treated...

Glucose 6 phosphatase catalytic subunit-3 (G6PC3) deficiency is a heterogenous disorder characterized by severe congenital neutropenia and variety of extrahematopoietic manifestations. Inflammatory bowel disease like colitis an uncommon complication G6PC3 deficiency, described only in adolescent adults. Herein, we describe inflammatory 10-year-old girl with due to while she was on high-dose filgrastim. Switching from filgrastim (pegylated filgrastim) Pegfilgrastim led rapid resolution...

Primary non-Hodgkin lymphoma (NHL) of lacrimal drainage system (LDS) is quite rare in children, but it important to expedite early diagnosis an effort alter possible life-threatening disease since they are usually misdiagnosed as chronic dacryocystitis. In the literature, there few examples tumors LDS children. The authors herein report two pediatric cases extranodal marginal zone mucosa-associated lymphoid tissue (MALT lymphoma) originating from sac attempt increase knowledge about clinical...

To evaluate the neuroprotective effect of rosuvastatin, in a rat experimental glaucoma model.Ocular hypertension was induced right eyes Long-Evans rats (n=30) by cauterization three episcleral veins. Left were defined as controls. Rats divided into five groups: oral intravitreal oral+intravitreal sham and without intervention. sacrificed at day 14. Retinal ganglion cell (RGC) number assessed histopathological analysis. Terminal deoxynucleotidyl transferase-mediated dUTP-nick end-labeling...

<b>Background and Study Aims</b> Tufted angiomas (TAs) are rare, benign vascular neoplasms of childhood mainly localized in the skin subcutaneous tissues. TAs progressive, slowly growing, characteristically involve superficial or deep muscle fascia tissue. frequently seen before age 5 years (60 to 70%) have no sex predominance. TA following pregnancy among immunosuppressive drug users was rarely reported literature. is extremely rare patients older than 60 years. <b>Patient</b> A 73-year-old...

Abstract Objectives We aimed to investigate the potential use of expression apoptotic signaling pathway genes rat in skin wound age estimation. Material and methods For this purpose, we formed cutting tool injuries using a scalpel an experimental model. Then, assessed Caspase 3, 8 9 mRNA levels by quantitative real-time PCR protein immunohistochemistry wounds. In addition, used TUNEL assay detect cells. Results observed that 3 level significantly increased (2.1±0.4 folds) on day (p&lt;0.05)...

Malignant pericardial effusion may affect almost 15 of the patients with underlying malignancies which deteriorates prognosis. The prognostic significance fluid cytology is under-represented in previous studies.A total 73 symptomatic treated pericardiocentesis were included this retrospective analysis. Macroscopic appearance, biochemical features, and cytological findings obtained. Patients divided into 3 groups: (i) without malignancy, (ii) malignancy negative cytology, (iii) positive...

Abstract Background The aim of the current study was to investigate effects chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) on bladder function via prostate-to-bladder cross-sensitization in a rat model lipopolysaccharide (LPS)-induced prostate inflammation. Methods Male rats were intraprostatically injected with LPS or saline, serving as control. Micturition parameters examined metabolic cage 10 14 days later. Subsequently, evaluate function, cystometry performed. cycles induced...