A5024279580- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Intraoperative Neuromonitoring and Anesthetic Effects
- Osteoarthritis Treatment and Mechanisms
- Vestibular and auditory disorders
- Motor Control and Adaptation
- Spatial Neglect and Hemispheric Dysfunction
- Extracellular vesicles in disease
- Neurological disorders and treatments
- Total Knee Arthroplasty Outcomes
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Orthopaedic implants and arthroplasty
- Modular Robots and Swarm Intelligence
- Knee injuries and reconstruction techniques
- Cell Adhesion Molecules Research
- Stroke Rehabilitation and Recovery
- Shoulder Injury and Treatment
- Glycogen Storage Diseases and Myoclonus
- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Adipose Tissue and Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Genetics and Neurodevelopmental Disorders
- Electrohydrodynamics and Fluid Dynamics
Kuopio University Hospital
2019-2025
University of Eastern Finland
2019-2025
Finland University
2023
This study investigated relationships between fatty acid (FA) profiles of extracellular vesicles (EVs) and cartilage degradation, functional limitations, pain, psychological well-being in knee osteoarthritis (KOA). Fasting plasma was collected from controls (n = 10), end-stage KOA patients at baseline 12) 3 12 months 11 9) after joint replacement surgery, synovial fluid (SF) 10). EVs were isolated with the exoEasy Maxi Kit or size-exclusion chromatography, EV FAs analyzed gas...
Abstract Background Emerging evidence suggests that extracellular vesicles (EVs) can play roles in inflammatory processes and joint degradation primary osteoarthritis (OA), a common age-associated disease. EV subpopulations express tetraspanins platelet markers may reflect OA pathogenesis. The present study investigated the associations between these surface articular cartilage degradation, subjectively objectively assessed pain, functional limitations knee (KOA). Methods Serum EVs were...
Abstract Objective To develop and assess an automatic robust knee musculoskeletal finite element (MSK-FE) modeling pipeline. Methods Magnetic resonance images (MRI) were used to train nnU-Net networks for auto-segmentation of bones (femur, tibia, patella, fibula), cartilages patella), menisci, major ligaments. Two different MRI sequences broaden applicability. Next, we created MSK-FE models unseen dataset using two pipelines: template-based auto-meshing. MSK had personalized geometries with...
Navigated transcranial magnetic stimulation (nTMS) is targeted at different cortical sites for diagnostic, therapeutic, and neuroscientific purposes. Correct identification of the target areas important achieving desired effects, but it challenging when no direct responses arise upon area stimulation. We aimed utilizing atlas-based marking nTMS targeting to present a convenient, rater-independent method overlaying individual with brain anatomy.We developed pipeline, which fits atlas enables...
Repetition suppression (RS), i.e., the reduction of neuronal activity upon repetition an external stimulus, can be demonstrated in motor system using transcranial magnetic stimulation (TMS). We evaluated RS relation to neuroplastic changes induced by paired associative (PAS). An paradigm, consisting 20 trains four identical suprathreshold TMS pulses 1 s apart, was assessed for motor-evoked potentials (MEPs) 16 healthy subjects, before and following (at 0, 10, min) a common PAS protocol. For...
Transcranial magnetic stimulation (TMS) can induce motor evoked potentials (MEPs). In TMS applications, near-threshold intensities (SIs) are often used for characterizing corticospinal excitability using MEPs. We aimed to characterize the individual recruitment of MEPs and test assumptions related selection suprathreshold SI. utilized MEP data from a right-hand muscle induced at variable SIs. The single-pulse (spTMS) previous studies (27 healthy volunteers), as well new measurements (10...
Transcranial magnetic stimulation (TMS) coupled with electroencephalography (EEG) possesses diagnostic and therapeutic benefits. However, TMS provokes a large pulse artifact that momentarily obscures the cortical response, presenting significant challenge for EEG data interpretation. We examined how intensity (SI), sampling frequency (Fs) synchronization of influence amplitude duration artifact. In eight healthy subjects, single-pulse was administered to primary motor cortex, due its...
: To develop and assess an automatic robust knee musculoskeletal finite element (MSK-FE) modeling pipeline.
Navigated transcranial magnetic stimulation (nTMS) is a widely used tool for motor cortex mapping. However, the full details of activated cortical area during mapping remain unknown due to spread stimulating electric field (E-field). Computational tools, which combine E-field with physiological responses, have potential revealing source area. We applied minimum-norm estimate (MNE) method in realistic head geometry nTMS mappings leg and hand muscles. calculated MNE also spherical assess...
Transcranial magnetic stimulation (TMS) can induce motor evoked potentials (MEPs). In TMS applications, near-threshold intensities (SIs) are often used for inducing MEPs and characterizing corticospinal excitability. We aimed to characterize the individual recruitment of test assumptions related selection suprathreshold SI. utilized MEP data from a right hand muscle induced at variable SIs. The single-pulse (spTMS) previous studies (27 healthy volunteers), as well new measurements (10...
Transcranial magnetic stimulation (TMS) can induce motor evoked potentials (MEPs). In TMS applications, near-threshold intensities (SIs) are often used for inducing MEPs and characterizing corticospinal excitability. We aimed to characterize the individual recruitment of test assumptions related selection suprathreshold SI. utilized MEP data from a right-hand muscle induced at variable SIs. The single-pulse (spTMS) previous studies (27 healthy volunteers), as well new measurements (10...