A5008923457- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Congenital Heart Disease Studies
- Aortic aneurysm repair treatments
- Coronary Artery Anomalies
- Vascular anomalies and interventions
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- COVID-19 Clinical Research Studies
- Vascular Procedures and Complications
- Pericarditis and Cardiac Tamponade
- Trauma Management and Diagnosis
- Cardiac pacing and defibrillation studies
- Cardiac Ischemia and Reperfusion
- Cardiac tumors and thrombi
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
Kartal Koşuyolu High Specialization Training and Research Hospital
2016-2025
Sağlık Bilimleri Üniversitesi
2018-2023
University of Health Science
2022
Sakarya University
2015-2019
Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi
2013-2018
Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi
2018
Burdur Mehmet Akif Ersoy Üniversitesi
2014
Orient-Institut Istanbul
2013
Istanbul Eye Hospital
2010
Haseki Eğitim ve Araştırma Hastanesi
2006
Carney complex (CNC) is a familial multiple neoplasia syndrome characterized by cardiac and extracardiac myxomas in the setting of spotty skin pigmentation endocrinopathy. We previously identified PRKAR1A (regulatory subunit 1α protein kinase A) mutations CNC. Mutational analyses gene 51 unrelated CNC probands now detect 65%. All mutations, except for one unique missense mutation, lead to haploinsufficiency. Therefore, we studied consequences prkar1a haploinsufficiency mice. Although did not...
Abstract Background: The aim of this study was to evaluate the frequency requirement for permanent pacing and related risk factors after aortic valve replacement. Methods: Among 465 patients operated between 1994 2004, 19(4.1%) with a mean age 49.9 ± 17.2 years required implantation pacemaker. Eleven them were female (57.9%). main indication stenosis (89.5%). Severe annular calcification documented in 78.9% them, bicuspid 57.9%. Results: Risk replacement (AVR) identified by univariate...
Different surgical strategies have been evolved for the treatment of ruptured sinus Valsalva aneurysm (RSVA) from simple primary closure to patching rupture site by a dual chamber approach. We reviewed our 25-year experience and current literature regarding efficacy different approaches. A retrospective review identified 55 patients who underwent RSVA repair between 1985 2011. The mean age was 30.9 ± 12.1 years. originated right coronary in 43 (78.2%), non-coronary 11 (20.0%) left 1. Rupture...
Purpose: The purpose of this study was to research the use near-infrared spectroscopy (NIRS) on neurocognitive functions in patients undergoing coronary artery bypass grafting (CABG) with asymptomatic carotid disease.Methods: design carried out participation 79 a prospective, randomized and double blind control method. were separated into two groups as NIRS (n = 43) no 36). A test applied preoperatively postoperatively all before discharge. Cognitive evaluated by applying Montreal Assessment...
Aortic root abscess is the most severe sequela of infective endocarditis, and its surgical management a complicated procedure because high risk morbidity death. Twenty-seven patients were included in this 15-year retrospective study: 21 (77.8%) with native- 6 (22.2%) prosthetic-valve endocarditis. The reconstruction aortic consisted valve replacement 19 (70.4%) (11) or without (8) pericardial patch, total 7 (25.9%); 5 27 (18.5%) underwent modified Bentall flanged conduit. Only one patient...
Melatonin has been shown to diminish ischemia-reperfusion (I/R) injury in many tissues. The main aim of this study was evaluate the protective antioxidant effect melatonin skeletal muscle during I/R injury. Wistar albino rats were randomly divided into three groups. Hindlimb ischemia achieved by clamping common femoral artery two groups but not control group. Limbs rendered ischemic for 1.5 hr; at end reperfusion period hr tissue samples taken histological evaluation and biochemical...
Minimizing the use of blood component can reduce known and unknown transfusion risks, preserve bank resources, decrease healthcare costs. Red Blood Cell (RBC) is common after cardiac surgery associated with adverse perioperative outcomes, including mortality. Acute normovolemic hemodilution (ANH) may bleeding need for product surgery. However, its blood-saving effect impact on major outcomes remain uncertain.
BackgroundMinimally invasive extracorporeal circulation (MiECC) has been introduced to mitigate the inflammatory response and reduce blood transfusion needs compared conventional cardiopulmonary bypass (CPB) perioperatively. A hybrid system (HS) that merges aspects of both traditional CPB MiECC aims optimize patient perioperative outcomes. This study focuses on comparing postoperative rates, intensive care unit (ICU) course, biochemical parameters between HS MiECC. Materials MethodsThis...
Whether an anticoagulation strategy combining bivalirudin and aspirin during extracorporeal membrane oxygenation (ECMO) would prolong oxygenator use is unknown. No clear data exist on life span prolonged ECMO use. We evaluated 70 adult patients who received due to coronavirus disease 2019 (COVID-19)-associated acute respiratory distress syndrome for at least 7 days required no or one replacement ECMO-circuit thrombosis. Anticoagulation parameters mainly included activated partial...
Corin is a cardiac protease that plays role in transforming pro-natriuretic peptides into their active biological forms. This study aimed to investigate the relationship between serum corin levels and functional capacity patients with advanced heart failure. cross-sectional included 88 consecutive LVEF (Left ventricular ejection fraction) <25% who were referred tertiary cardiovascular center. Serum measured using ELISA (Enzyme-linked immunosorbent assay) prior CPET (Cardiopulmonary exercise...
Abstract Objective: Between 1994 and December 2003, 55 patients were operated for cardiac myxoma in Koşuyolu Heart Research Hospital Istanbul. Methods: We retrospectively analyzed our results according to the preoperative characteristics, operative procedures, postoperative courses. Results: Of operated, 36 (65.4%) female 19 (34.6%) male. The average age of was 48 ± 15.5 years (range, 12–75). Thirteen (23.6%) previously had cerebrovascular accidents. Peripheral arterial emboli occurred 11...
Subaortic stenosis (SAS) is a wide spectrum of anatomical derangements ranging from discrete fibrous membrane to tortuous tunnel with or without aortic annulus hypoplasia. We have reviewed 88 patients undergoing surgery for SAS over 15-year period. There were 47 male and 41 female mean age 19.8 +/- 10.6 years (range 11 39). Fifty-eight had subaortic membrane, 30 diffuse subvalvular stenosis. The systolic pressure gradients found be 86.5 31.4 mmHg 48 145 mmHg). Ten mild 13 moderate-to-severe...
Object No definitive treatment for spinal cord injuries (SCIs) exists, and more research is required. The use of agmatine [4-(aminobutyl)-guanidine-NH 2 -CH -NH-C(-NH )(=NH)], a guanidinium compound formed by decarboxylation l -arginine arginine decarboxylase, neurotransmitter–neuromodulator with both N -methyl- d -aspartate receptor (NMDAR)–antagonizing nitric oxide synthase (NOS)–inhibiting activities. purpose this study was to demonstrate the dose-dependent activity agmatine, an inducible...
Hypercholesterolemia has been found to be associated with aortic valve stenosis and resemble the inflammatory process of atherosclerosis in many studies. The aim this study was investigate role hypercholesterolemia development calcification different etiologies.The included 988 patients rheumatic, congenital, or degenerative stenosis, who underwent replacement at Koşuyolu Heart Research Hospital between 1985 2005. Effects high low-density lipoprotein level on calcific massive were analyzed...