A5011157630- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- Brain Metastases and Treatment
- Neuroendocrine Tumor Research Advances
- Bladder and Urothelial Cancer Treatments
- Redox biology and oxidative stress
- Medical Imaging Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Lung Cancer Research Studies
- Receptor Mechanisms and Signaling
- Cancer Genomics and Diagnostics
- Hedgehog Signaling Pathway Studies
- Tumors and Oncological Cases
- Urinary and Genital Oncology Studies
- Glioma Diagnosis and Treatment
- Renal and Vascular Pathologies
- Chemical Synthesis and Analysis
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Estrogen and related hormone effects
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
NorthShore University HealthSystem
2018-2025
University of Chicago
2017-2025
Weill Cornell Medicine
2021-2024
Cornell University
2021-2024
Cleveland Clinic
2022
Lander Institute
2022
University of Washington
2022
University of Kufa
2021
Massachusetts General Hospital
2019
The University of Texas Health Science Center at Houston
2019
Abstract Anaplasia may be identified in a subset of tumors with presumed pilocytic astrocytoma ( PA ) component or piloid features, which associated aggressive behavior, but the biologic basis this change remains unclear. Fifty‐seven resections from 36 patients (23 M, 13 F, mean age 32 years, range 3–75) were included. A clinical diagnosis NF 1 was present 8 (22%). Alternative lengthening telomeres ALT assessed by telomere‐specific FISH and/or CISH . combination immunohistochemistry, DNA...
Abstract Purpose: Patients with neuroendocrine prostate cancer (NEPC) are often managed immunotherapy regimens extrapolated from small-cell lung (SCLC). We sought to evaluate the tumor immune landscape of NEPC compared other types and SCLC. Experimental Design: In this retrospective study, a cohort 170 patients 230 RNA-sequencing 104 matched whole-exome sequencing data were analyzed. Differences in stromal constituents, frequency genomic alterations, associations outcomes evaluated. Results:...
GLI1 encodes a transcription factor that targets cell cycle regulators affecting stem proliferation. gene fusions were initially described in pericytomas with t[7;12] translocation and more recently gastric plexiform fibromyxomas gastroblastomas. This study describes the clinicopathologic, immunohistochemical, molecular features of three intestinal-based neoplasms harboring fusions. We studied unique mesenchymal small bowel tumors. Paraffin embedded tumor tissues from these cases 62...
Abstract Objective The highly specialized language used in prostate biopsy pathology reports coupled with low rates of health literacy leave some patients unable to comprehend their medical information. Patients’ use online search engines can lead misinterpretation results and emotional distress. Artificial intelligence (AI) tools such as ChatGPT (OpenAI) could simplify complex texts help patients. This study evaluates patient-centered generated by ChatGPT. Methods Thirty-five self-generated...
216 Background: In this prospective study at a community-based hospital, we conducted comprehensive genomic testing to identify pts with actionable variants. We previously showed that resulted in identification of 38% recommendation for treatment, predominantly PARP inhibitor (PARPI). now report on the clinical outcomes who received treatment based testing. Methods: Pts mCRPC had cfDNA using PredicineCare NGS assay and germline tissue (archival metastasis) Northshore Expanded Cancer Panel....
Abstract Background Characterization of circulating tumor DNA (ctDNA) has been integrated into clinical practice. Although labs have standardized validation procedures to develop single locus tests, the efficacy on-site plasma-based next-generation sequencing (NGS) assays still needs be proved. Materials and Methods In this retrospective study, we profiled from matched tissue plasma samples 75 patients with cancer. We applied an NGS test that detects clinically relevant alterations in 33...
Sarcomatoid urothelial carcinoma (SUC) is a rare subtype of (UC) that typically presents at an advanced stage compared to more common variants UC. Locally and metastatic UC have poor long-term survival following progression on first-line platinum-based chemotherapy. Antibodies directed against the programmed cell death 1 protein (PD-1) or its ligand (PD-L1) are now approved be used in these scenarios. The need for reliable biomarkers treatment stratification still under research. Here, we...
BACKGROUNDProstate cancer is multifocal with distinct molecular subtypes. The utility of genomic subtyping has been challenged due to inter- and intrafocal heterogeneity. We sought characterize the subtype-defining alterations primary prostate across all tumor foci within radical prostatectomy (RP) specimens determine prevalence collision tumors.METHODSFrom Early Detection Research Network cohort, we identified 333 prospectively collected RPs from 2010 2014 assessed ETS-related gene (ERG),...
Although recent efforts have led to the development of highly effective androgen receptor (AR)-directed therapies for treatment advanced prostate cancer, a significant subset patients will progress with resistant disease including AR-negative tumors that display neuroendocrine features [neuroendocrine cancer (NEPC)]. On basis RNA sequencing (RNA-seq) data from clinical cohort tissue benign prostate, locally metastatic castration-resistant and NEPC, we developed multi-step bioinformatics...
Hirschsprung disease (HSCR) is a congenital disorder characterized by intestinal aganglionosis leading to pseudoobstruction. The majority of cases are limited the rectum or rectosigmoid (S-HSCR). A variably longer segment can be affected (L-HSCR), which may show many deviations from S-HSCR. We retrospectively reviewed 48 clinicopathologically confirmed total HSCR at single institution in 21-year period identify L-HSCR and determine their known features Eight were found where extended...
Meningeal carcinomatosis (MC) is a rare complication in breast cancer patients. It defined as diffuse or multifocal leptomeningeal metastasis.From our institution database, we retrospectively studied 19 patients diagnosed with MC the cerebrospinal fluid (CSF) 1997-2015, order to evaluate tumor prognostic markers, histologic subtypes, and clinical outcome.All were female, mean age of 53 years (range 36-75 years). The interval between diagnosis carcinoma was 28 months 6-62 months). median...
Hematological malignancies of the breast share a presentation similar to primary carcinomas but differ substantially in therapeutic approach and clinical outcomes. In this study, we investigate frequency hematological malignancies, their relative secondary occurrences, further characterize distinct histopathologies these with special focus on lymphomas. To our knowledge is one largest most comprehensive studies hematologic malignancies.We conducted retrospective review institution's...
Reactive nodular and diffuse histiocytic proliferations of mesothelial non‐mesothelial lined sites have been sporadically reported in the literature. However, there is no cytologic literature describing this process. We report a case reactive proliferation mimicking metastatic signet ring adenocarcinoma pleural fluid from 33‐year‐old white male. Ancillary studies such as immunohistochemistry should be used to elucidate cell origin avoid diagnostic errors.
In humans, subgemmal neurogenous plaques (SNPs) are normally found associated with taste buds. On histology, SNP may be mistaken for a neural neoplasm. The objective of this study was to correctly differentiate among head and neck lesions provide clinical pathologic information that assist in avoiding misdiagnosis. To our knowledge, is the first an estimate degree overdiagnoses mucosal area.Retrospective pathology chart review.All cases only mucosa oral cavity, oropharynx, or larynx from...
185 Background: Genomic testing in pts with mCRPC has become an important tool to identify actionable variants, particular on-label treatment recommendation. Testing previously required tumor tissue, but cfDNA is now approved as a companion diagnostic for specific HRR variants. In this prospective study at community-based hospital, we conducted comprehensive genomic We report results on variants specifically Methods: Pts had using the PredicineCare NGS assay and germline tissue (archival...
<p>Suppl Table S1. Clinical characteristics of metastatic patient cohort Suppl S2. The 361 gene signature identified in this study to classify T-cell immune clusters S3. 80 and stroma related signatures used quantify the TME S4. DEGs for SCLC versus NEPC tumors S5. NCI-Nature_2016 pathways enriched from vs NEPC</p>
<p>Suppl Figure 5. Comparative analysis between NEPC and SCLC.</p>
<p>Suppl Figure 3. Identification of gene modules associated with NEPC T-cell immune classes.</p>
<p>Suppl Figure 2. T-cell signature-based classification of prostate cancer types and other independent cohorts.</p>