A5022567341- Muscle Physiology and Disorders
- Catalytic Cross-Coupling Reactions
- Plant-derived Lignans Synthesis and Bioactivity
- CAR-T cell therapy research
- Natural product bioactivities and synthesis
- Biotin and Related Studies
- Synthetic Organic Chemistry Methods
- Ubiquitin and proteasome pathways
- Phytochemistry and Biological Activities
- Biochemical and Structural Characterization
- Exercise and Physiological Responses
- Model-Driven Software Engineering Techniques
Sagami Chemical Research Institute
2025
Kwansei Gakuin University
2020
Tokushima University
2010-2016
Although olefin metathesis is a superior method for the construction of olefins, synthesis fluoroolefins remains challenging. In this study, we report exploration ruthenium catalysts suitable ring-closing fluoroolefins. Using with appropriate six-membered N-heterocyclic carbene ligands, successfully synthesized various five- and fluorinated ring olefins. DFT calculations suggested that strong electron-donating properties moderate bulkiness ligands played crucial roles.
Abstract Deficiency of the Cbl‐b ubiquitin ligase gene activates macrophages in mice. This study aimed to elucidate pathophysiological roles muscle degeneration/regeneration ‐deficient We examined immune cell infiltration and cytokine expression cardiotoxin‐injected tibialis anterior Ablation delayed regeneration cardiotoxin‐induced skeletal damage compared with wild‐type CD8‐positive T cells were still present damaged on day 14 after cardiotoxin injection mice, but there was dispersal same...
Herein, we describe the first total synthesis of neostrictinin, a natural ellagitannin bearing ( R )‐hexahydroxydiphenoyl (HHDP) bridge between 4‐ and 6‐oxygens d ‐glucose. Among multitude 4,6‐ O ‐HHDP bridged ellagitannins, )‐axial chirality HHDP is quite rare as it less stable than corresponding S )‐isomer. The labile was constructed using two‐step bislactonization that involved: (1) monoacylation primary alcohol ethyl 2,3‐ ‐benzyl‐1‐thio‐β‐ ‐glucopyranoside protected )‐hexahydroxydiphenic...