A5026976984- Computational Drug Discovery Methods
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Cholinesterase and Neurodegenerative Diseases
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Synthesis and biological activity
- Antiplatelet Therapy and Cardiovascular Diseases
- Crystal structures of chemical compounds
- Wound Healing and Treatments
- Platelet Disorders and Treatments
- Chemical Synthesis and Analysis
- Reconstructive Surgery and Microvascular Techniques
- Ovarian cancer diagnosis and treatment
- Trypanosoma species research and implications
- Enzyme function and inhibition
- Mycotoxins in Agriculture and Food
- Spine and Intervertebral Disc Pathology
- Research on Leishmaniasis Studies
- Microbial Metabolic Engineering and Bioproduction
- Liver Disease Diagnosis and Treatment
- Natural Antidiabetic Agents Studies
- Probiotics and Fermented Foods
- Congenital gastrointestinal and neural anomalies
- Chemical Reactions and Isotopes
University of Central Florida
2011-2024
Florida State University
2024
Florida College
2024
AdventHealth Orlando
2004-2024
Allama Iqbal Medical College
2021-2023
University of Health Sciences Lahore
2023
Florida Hospital Cancer Institute
2008-2023
University of Windsor
2023
University of Malaya
2019-2022
University of Veterinary and Animal Sciences
2021
The present study explored phytochemicals, porcine pancreatic α-amylase (PPA) and lipase (PPL) inhibitory activities antioxidant potential of polar nonpolar extracts the leaves flowers Ocimum basilicum in-silico mode interaction between these enzymes major chemical constituents herb. hexane extract (HE) hydro-ethanolic (EE) obtained sequentially were used to estimate PPA PPL activities, total phenolic content (TPC) flavonoid (TFC). Chemical essential oils HE determined by GC-MS (Gas...
Cisplatin is amongst the most potent chemotherapeutic drugs with applications in more than 50% of cancer treatments, but dose-dependent side effects limit its usefulness. Berberis vulgaris L. (B. vulgaris) has a proven role several therapeutic traditional medicinal system. High-performance liquid chromatography was used to quantify berberine, alkaloid methanolic root extract B. (BvRE). Berberine chloride BvRE found be 10.29% w/w. To assess prophylactic and curative protective on...
Tumorigenesis in humans is a multistep progression that imitates genetic changes leading to cell transformation and malignancy. Oncogenic kinases play central role cancer progression, rendering them putative targets for the design of anti-cancer drugs. The presented work aims identify potential multi-target inhibitors oncogenic receptor tyrosine (RTKs) serine/threonine (STKs). For this, chemoinformatics structure-based virtual screening approaches were combined with an vitro validation lead...
Withania coagulans (W. coagulans) is well-known in herbal medicinal systems for its high biological potential. Different parts of the plant are used against insomnia, liver complications, asthma, and biliousness, as well it reported to be sedative, emetic, diuretic, antidiabetic antimicrobial, anti-inflammatory, antitumor, hepatoprotective, antihyperglycemic, cardiovascular, immuno-suppressive central nervous system depressant. Withanolides present W. have attracted an immense interest...
The outbreak of 2019-novel coronavirus (SARS-CoV-2) that causes severe respiratory infection (COVID-19) has spread in China, and the World Health Organization declared it a pandemic. However, no approved drug or vaccines are available, treatment is mainly supportive through few repurposed drugs. urgency situation requires development SARS-CoV-2-based vaccines. Immunoinformatic molecular modelling time-efficient methods generally used to accelerate discovery design candidate peptides for...
Background: The perfusion index (PI) has been found to be a reliable indicator of peripheral and can used monitor in neonates undergoing surgical procedures. To study correlation with the need for post op mechanical ventilation, ICU care inotropic support surgery. Methods: Eighty posted surgery were enrolled after taking proper written informed consent from parents. HR, BP SPO2 PI recorded at 3 minutes interval first 30 surgery, followed by every 5 till end procedure. Neonates requiring...
Background: Stroke significantly impairs hand dexterity and quality of life, affecting independence in daily activities. Rehabilitation plays a crucial role restoring upper limb function, with the Bobath Approach Constraint-Induced Movement Therapy (CIMT) being widely used interventions. While both therapies aim to improve motor recovery, CIMT emphasizes repetitive, task-specific training, whereas focuses on normalizing movement patterns. This study evaluates compares effectiveness these two...
The aim of this laboratory study was to evaluate the monomer leaching and degree conversion (DC) from experimental bioactive resin composites (RBCs) do comparison with commercial bulkfill packable composites. Experimental dimethacrylatebased were reinforced silanated nano-hydroxyapatite (30 45 wt%). ion DC these compared contrasted SDR™ Filtek P60™ by using high performance liquid chromatography (HPLC) Fourier transform infrared spectroscopy (FTIR), respectively. A significant difference...
Abstract Ifosfamide is a widely used chemotherapeutic agent having broad-spectrum efficacy against several tumors. However, nephro, hepato, neuro cardio, and hematological toxicities associated with ifosfamide render its use limited. These side effects could range from organ failure to life-threatening situations. The present study aimed evaluate the attenuating efficiency of Berberis vulgaris root extract ( Bv RE), potent nephroprotective, hepatoprotective, lipid-lowering agent,...
With expanding recent outbreaks and a lack of treatment options, the Zika virus (ZIKV) poses severe health concern. The availability ZIKV NS2B-NS3 co-crystallized structures paved way for rational drug discovery. A computer-aided structure-based approach was used to screen diverse library compounds against protease. top hits were selected based on various binding free energy calculations followed by per-residue decomposition analysis. then evaluated their biological potential with protease...
Android smartphone apps are becoming increasingly popular, but their security is a concern. Malware can cause damage to mobile devices and servers. Developing detection technologies avoid attacks crucial for protecting consumers' devices, desktops, The goal of this study malware attacks, which addressed via static, dynamic hybrid features. Combating such requires effective tools. framework restricts the deep learning architecture in order find dependencies between APK-retrieved attributes....
Prostaglandin E2 (PGE2) has been known to modulate immune responses by inhibiting T-cell activation following hemorrhagic and traumatic injury. Recently, we documented a sepsis-related depression in concanavalin A (ConA)-induced proliferation intracellular Ca2+ (Ca2+i) mobilization. The present study evaluated the potential role of PGE2 attenuation signaling T cells. Sepsis was induced rats implanting into their abdomen fecal pellets containing Escherichia coli (150 CFU) Bacteroides fragilis...
The urea uptake system was studied with regard to its repression and derepression in the cyanobacterium, Anabaena doliolum. of energy-dependent repressed ammonia grown cells. Repression by ammonium did not require assimilation or de novo protein synthesis, suggesting that itself repressor signal. system, however, required synthesis glutamine synthetase activity.