A5102823372- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Epilepsy research and treatment
- Intensive Care Unit Cognitive Disorders
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Radiation Dose and Imaging
- Infectious Encephalopathies and Encephalitis
- Clinical Reasoning and Diagnostic Skills
- Advanced X-ray and CT Imaging
- Simulation-Based Education in Healthcare
- Anatomy and Medical Technology
- Vascular Malformations Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Biomedical and Chemical Research
- Brain Metastases and Treatment
- S100 Proteins and Annexins
- Electroconvulsive Therapy Studies
- Sepsis Diagnosis and Treatment
University of Maryland, Baltimore
2014-2024
Neurology, Inc
2024
International Trauma Anesthesia and Critical Care Society
2023
Jersey Shore University Medical Center
2023
Albert Einstein College of Medicine
2023
Henry Ford Health System
2023
Montefiore Medical Center
2023
SUNY Upstate Medical University
2023
University of Maryland Medical Center
2017-2023
Hackensack Meridian Health
2023
In the United States, Black, Hispanic, and Asian Americans experience excessively high incidence rates of hemorrhagic stroke compared with White Americans. Women higher subarachnoid hemorrhage than men. Previous reviews detailing racial, ethnic, sex disparities in have focused on ischemic stroke. We performed a scoping review diagnosis management States to identify areas disparities, research gaps, evidence inform efforts aimed at health equity.
The efficacy of topiramate, a novel therapeutic agent approved for the treatment seizure disorders, was evaluated in model traumatic brain injury (TBI). Adult male rats were anesthetized (sodium pentobarbital, 60 mg/kg, i.p.), subjected to lateral fluid percussion (n = 60) or sham 47) and randomized receive either topiramate vehicle at 30 min (30 8, 20 32 h postinjury p.o.). In Study A, memory using Morris water maze 48 postinjury, after which tissue regional cerebral edema. B, animals motor...
The NTera2 (NT2) cell line is a homogeneous population of cells, which, when treated in vitro with retinoic acid, terminally differentiate into postmitotic neuronal NT2N cells. Although neurons transplanted the acute (24 h postinjury) period survive for up to 1 month following experimental traumatic brain injury (TBI), nothing known their ability longer periods or effects engrafted during chronic postinjury period. Adult male Sprague-Dawley rats (n = 348; 360–400 g) were initially...
Advances in adult learning theory and instructional technologies provide opportunities to improve neurology knowledge acquisition. This scoping review aimed survey the emerging landscape of educational innovation clinical neurology. With assistance a research librarian, we conducted literature search on November 4, 2021, using following databases: PubMed, Embase, Scopus, Cochrane Library, Education Resources Information Center, PsycINFO. We included studies innovative teaching methods for...
Objective: There has been controversy over whether diffusion-perfusion mismatch provides a biomarker for the ischemic penumbra. Regions of that do not progress to infarct in absence reperfusion are considered represent "benign oligemia." However, at least some cases (particularly large vessel stenosis), this hypoperfused tissue may remain dysfunctional prolonged period without progressing and recover function if eventually reperfused. We hypothesized patients with persistent using...
Objectives: Posttraumatic hypotension is believed to increase morbidity and mortality in traumatically brain-injured patients. Using a clinically relevant model of combined traumatic brain injury with superimposed hemorrhagic rats, the present study evaluated whether reduction mean arterial blood pressure aggravates regional edema formation, cell death, neurologic motor/cognitive deficits associated injury. Design: Experimental prospective, randomized rodents. Setting: laboratory at...
<h3>Background and Objectives</h3> Delays in treatment of both herpes simplex virus (HSV) encephalitis seizures are associated with poor patient outcomes, but many physicians fail to recognize HSV despite classic presenting symptoms. Our goal was assess trainee performance a simulation-based case as the underlying etiology refractory status epilepticus. <h3>Methods</h3> This is prospective, observational, single-center study participants ranging from subinterns attending managing viral...
Multidisciplinary acute stroke teams improve ischemic management but may hinder trainees' education, which in turn contribute to poorer outcomes community hospitals on graduation. Our goal was assess graduate neurology trainee performance independently of a multidisciplinary team the stroke, tissue plasminogen activator (tPA)-related hemorrhage, and cerebral herniation syndrome.In this prospective, observational, single-center simulation-based study, participants (subinterns attending...
To assess trainees' performance in managing a patient with post-cardiac arrest complicated by status epilepticus.In this prospective, observational, single-center simulation-based study, trainees ranging from sub interns to critical care fellows evaluated and managed post cardiac patient, epilepticus. Critical action items were developed modified Delphi approach based on American Heart Association guidelines the Neurocritical Care Society's Emergency Neurological Life Support protocols. The...
Introduction Evidence for optimal analgesia following subarachnoid hemorrhage (SAH) is limited. Steroid therapy pain refractory to standard regimens common despite lack of evidence its efficacy. We sought determine if steroids reduced or utilization other analgesics when given headache SAH. Methods performed a retrospective within-subjects cohort study SAH patients who received headache. compared daily scores, total opioid, and acetaminophen doses before, during, after steroids. Repeated...
Ischemia affecting two thirds of the MCA territory predicts development malignant cerebral edema. However, early infarcts are hard to diagnose on conventional head CT. We hypothesize that high-energy (190keV) virtual monochromatic images (VMI) from dual-energy CT (DECT) imaging enables earlier detection secondary injury edema (MCE).
OBJECTIVES/GOALS: Accurate classification of disorders consciousness (DoC) is key in developing rehabilitation plans following brain injury. The Coma Recovery Scale-Revised (CRS-R) a sensitive measure consciousness. We explore feasibility, safety and impact CRS-R guided rehab hemorrhagic stroke patients with DoC evaluate predictors recovery. METHODS/STUDY POPULATION: Consecutive non-traumatic stroke, defined as subarachnoid hemorrhage (SAH) or intracerebral (ICH), receiving serial...
OBJECTIVES/GOALS: Multiple induction agents can facilitate rapid sequence intubation (RSI) in management of refractory status epilepticus (rSE), many which have anti-seizure properties. We examine the efficacy and safety used during RSI rSE. METHODS/STUDY POPULATION: conducted a single-center retrospective review patients admitted to neuro-ICU intubated for Propofol, ketamine benzodiazepines were considered medication (ASMs), etomidate was not. Patients treated with propofol or midazolam...
Accurate classification of disorders consciousness (DoC) is key in developing rehabilitation plans after brain injury. The Coma Recovery Scale-Revised (CRS-R) a sensitive measure validated the phase care. We tested feasibility, safety, and impact CRS-R-guided ICU for patients with DoC acute hemorrhagic stroke.
OBJECTIVE Laser interstitial thermal therapy (LITT) is an emerging tool for treating a variety of focal brain lesions, including recurrent high-grade glioma (HGG). While the efficacy and uses LITT have been well studied, impact this treatment on patient functional outcomes has not analyzed in detail. This study sought to better define role patients with HGG, examining which exhibit good after LITT, determine risk factors worsening neurological function. METHODS The medical records treated...
A 23-year-old man was found at a train station with convulsions. He treated benzodiazepines in the field and transferred to nearest emergency department, where he intubated. This episode had been preceded by 2-week history of headaches, nausea, confusion, staring spells that precluded patient from going work. His mother also noted his eye started appear “droopy” several days prior presentation. She stated no recent travel, sick contacts, or tick insect bites. recently prescribed taking...
OBJECTIVE: To determine if (1) the MRI defined diffusion-perfusion mismatch (DPMM) predicts acute ischemic stroke patients who are likely to improve within 10 days; and (2) changes in volume of dysfunctional tissue reflect cortical function. BACKGROUND: Much attention has been paid use DPMM selecting for revascularization therapy. Acute outcome typically quantified by NIHSS. We hypothesized that is potentially salvageable, tissue, cognitive testing may upon NIHSS quantify this tissue....