A5040040390- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberous Sclerosis Complex Research
- Cardiac Imaging and Diagnostics
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory viral infections research
- Medical Imaging and Pathology Studies
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Eosinophilic Disorders and Syndromes
- IgG4-Related and Inflammatory Diseases
- Genomics and Chromatin Dynamics
- Acute Myeloid Leukemia Research
- Research on Leishmaniasis Studies
- Chromosomal and Genetic Variations
- Nutrition and Health in Aging
- Histiocytic Disorders and Treatments
- Esophageal and GI Pathology
- Congenital heart defects research
- Vasculitis and related conditions
- Biomarkers in Disease Mechanisms
- Eosinophilic Esophagitis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Moyamoya disease diagnosis and treatment
Universidade de São Paulo
2014-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2019-2024
Instituto do Coração
2018-2024
University College Hospital at Westmoreland Street
2024
University College London
2024
University of Chicago
2008-2013
The various organogenic programs deployed during embryonic development rely on the precise expression of a multitude genes in time and space. Identifying cis -regulatory elements responsible for this tightly orchestrated regulation gene is an essential step understanding genetic pathways involved development. We describe strategy to systematically identify tissue-specific that share combinations sequence motifs. Using heart as experimental framework, we employed combination Gibbs sampling...
Background Lymphangioleiomyomatosis (LAM) is a rare disease that can occur sporadically (S-LAM) or associated with the tuberous sclerosis complex (TSC-LAM). The natural history of LAM not completely understood, including whether there difference between clinical courses two forms. This study aimed to compare clinical, functional and tomographic features S-LAM TSC-LAM, evaluate annual rates change in lung function. Methods retrospective cohort included patients followed up 1994 2019....
ABSTRACT Objective: Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by the accumulation of surfactant, which composed proteins and lipids. PAP caused deficit macrophage activity, for main treatment whole-lung lavage (WLL). We report experience at referral center in Brazil. Methods: This was retrospective study involving patients with followed between 2002 2016. analyzed information regarding clinical history, diagnostic methods, treatments, outcomes, as well data on...
Abstract Background The diagnosis of cardiac involvement in sarcoidosis is challenging and often expensive. Purpose aim this study to assess whether a new strain index proposed by the authors has incremental value evaluation involvement, compared use left ventricular (LV) global longitudinal (GLS). Methods This single-center, non-blinded, pilot cross-sectional study. Patients both genders, >18 years old, with confirmed according Heart Rhythm Society criteria, controls consisting...
Abstract Background Cardiac involvement is associated with worse prognosis and mortality in sarcoidosis. Diagnosis often requires expensive less available tests. Purpose The aim of this study to evaluate whether non-invasive measurement myocardial work by transthoracic echocardiogram has incremental value the diagnosis cardiac compared left ventricular (LV) global longitudinal strain (GLS). Methods This a cross-sectional, non-blinded, single-center pilot study. Patients both genders >...
<b>Background:</b> Serum vascular endothelial growth factor D (VEGF-D) has been proposed as a diagnostic and prognostic biomarker in patients with lymphangioleiomyomatosis (LAM). <b>Objectives:</b> To compare VEGF-D serum levels between LAM healthy women to define its correlation clinical functional parameters. <b>Methods:</b> A cross-sectional study that included sporadic (86%) tuberous sclerosis complex associated (14%) followed Brazilian reference centre. <b>Results:</b> Seventy-one 10...
Abstract Introduction Sarcoidosis is a multi-systemic granulomatous disease of unknown etiology. Cardiac sarcoidosis (CS) has proven to be clinically significant cause unexplained ventricular dysfunction, atrioventricular block (AVB) and tachyarrhythmias (VT). Studies have suggested that manifest cardiac involvement occurs in only 5% patients with sarcoidosis. However, recent imaging studies shown can observed up 54.9% extracardiac sarcoidosis, mostly silent, but eventually into...