A5059105539- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Maternal and fetal healthcare
- Gastrointestinal motility and disorders
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cervical Cancer and HPV Research
- Bariatric Surgery and Outcomes
- Folate and B Vitamins Research
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy-related medical research
- Breastfeeding Practices and Influences
- Neonatal Respiratory Health Research
- Obesity, Physical Activity, Diet
- Cardiovascular Issues in Pregnancy
- Pelvic floor disorders treatments
- Grief, Bereavement, and Mental Health
- Crystallography and molecular interactions
- American Constitutional Law and Politics
- Body Composition Measurement Techniques
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Ectopic Pregnancy Diagnosis and Management
- Global Maternal and Child Health
Coombe Women & Infants University Hospital
2015-2024
Edith Cowan University
2023-2024
Johns Hopkins Hospital
2023
University College Dublin
2011-2022
University of North Carolina at Charlotte
2006-2022
The University of Western Australia
2010-2021
Trinity College Dublin
2001-2020
Baker Heart and Diabetes Institute
2019
Appalachian State University
2009-2018
Durham VA Health Care System
2018
CrystalExplorer is a native cross-platform program supported on Windows, MacOS and Linux with the primary function of visualization investigation molecular crystal structures, especially through decorated Hirshfeld surface its corresponding two-dimensional fingerprint, void spaces in via isosurfaces promolecule electron density. Over past decade, significant changes enhancements have been incorporated into program, such as capacity to accurately quickly calculate visualize quantitative...
We present an approach to understanding crystal packing via 'energy frameworks', that combines efficient calculation of accurate intermolecular interaction energies with a novel graphical representation their magnitude. In this manner intriguing questions, such as why some crystals bend applied force while others break, and one polymorph drug exhibits exceptional tabletability compared others, can be addressed in terms the anisotropy topology pairwise energies. This is sample organic...
We present a simple and more realistic alternative to the conventional approach of mapping void space by rolling probe sphere variable radius over fused-sphere representation molecular crystal. Based on isosurfaces procrystal electron density, this can be used locate visualise in crystalline materials, as well readily compute surface areas volumes voids. The method is quite general, computationally rapid, capable locating characterising all “empty” space, not just larger cavities channels,...
The energy of interaction between molecules is commonly expressed in terms four key components: electrostatic, polarization, dispersion, and exchange-repulsion. Using monomer wave functions to obtain accurate estimates repulsion energies along with Grimme's dispersion corrections, a series models are derived by fitting dispersion-corrected DFT for large number molecular pairs extracted from organic inorganic crystals. best performing model reproduces B3LYP-D2/6-31G(d,p)...
In one of his final essays, statesman and former United Nations secretary general Kofi Annan said, ‘Snakebite is the most important tropical disease you’ve never heard of’ [1]. Mr. firmly believed that victims snakebite envenoming should be recognised afforded greater efforts at improved prevention, treatment, rehabilitation. During last years life, he advocated strongly for World Health Organisation (WHO) global community to give priority this poverty its victims.
Background Correlates and predictors of mood disturbance at 3 days 6 weeks postpartum were assessed in Irish mothers their partners. Method The Edinburgh Postnatal Depression Scale (EPDS) the Highs used to assess 370 Socio-demographic, clinical obstetric data collected patients' first antenatal visit. Factors associated with EPDS scores ≥ 13 8 examined. Results On 11.4% scored 11% weeks, while 18.3% on 9% weeks. Scores interrelated. single status, unemployment, unplanned pregnancy, public...
Summary Aim To provide estimates of actual costs to deliver health care patients with functional bowel disorders, and assess the cost impact symptom severity, recency onset, satisfaction treatment. Methods We enrolled 558 irritable (IBS), 203 constipation, 243 diarrhoea 348 abdominal pain from primary gastroenterology clinics at a maintenance organization within weeks visit. Costs were extracted administrative claims. Symptom treatment out‐of‐pocket expenses assessed by questionnaires....
BACKGROUND Comorbid nongastrointestinal symptoms account for two-thirds of excess health-care costs in irritable bowel syndrome (IBS). OBJECTIVES To determine whether IBS patients are at greater risk specific comorbid disorders versus showing a general tendency to overreport symptoms; with inflammatory disease (IBD) show patterns comorbidity similar IBS; is explained by psychiatric disease; and occurs all patients. METHODS All 3,153 health maintenance organization diagnosis 1994–1995 were...
The Rome III classification system treats functional constipation (FC) and irritable bowel syndrome with (IBS-C) as distinct disorders, but this distinction appears artificial, the same drugs are used to treat both. This study's hypothesis is that FC IBS-C defined by not entities.In all, 1,100 adults a primary care visit for 1,700 age- gender-matched controls from health maintenance organization completed surveys 12 months apart; 66.2% returned first questionnaire. criteria identified 231...
OBJECTIVE: This study was designed to develop and test a home-based, guided imagery treatment protocol, using audio video recordings, that is easy for health care professionals patients use, inexpensive, applicable wide range of settings. METHODS: Thirty-four children, 6 15 years age, with physician diagnosis functional abdominal pain were assigned randomly receive 2 months standard medical or without treatment. Children who received only initially after months. monitored completion RESULTS:...
OBJECTIVES Irritable bowel syndrome (IBS) patients show pain hypersensitivity and hypercontractility in response to colonic or rectal distention. Aims were determine whether predominant habits IBS symptom severity are related sensitivity, colon motility, smooth muscle tone. METHODS One hundred twenty-nine classified as with diarrhea (IBS-D, N = 44), constipation (IBS-C, 29), mixed (IBS-M, 45), unspecified (IBS-U, 11) based on stool consistency, 30 healthy controls (HC) studied. A manometric...
Previous studies on weight gain in pregnancy suggested that maternal average increased by 0.5-2.0 kg the first trimester of pregnancy. This study examined whether mean or body composition changes pregnancy.Prospective observational study.We studied 1,000 Caucasian women booking for antenatal care pregnancy.Large university teaching hospital.Maternal height and were measured digitally a standardized way Body Mass Index (BMI) was calculated. Maternal using segmental multifrequency...
Summary Background Studies suggest that the positive predictive value of Rome II criteria for diagnosing irritable bowel syndrome can be enhanced by excluding red flag symptoms suggestive organic diseases. Aim We assessed utility flags detecting diseases in patients diagnosed their physicians. Methods Systematic chart reviews were completed 1434 with clinical diagnoses syndrome, abdominal pain, diarrhoea or constipation, who also questionnaires to identify and symptoms. Results The overall...
The objectives of this study were to determine how variable stool consistency is in patients with irritable bowel syndrome (IBS) and assess the relationship between gastrointestinal symptoms.Individuals a physician diagnosis IBS recruited by advertisement. Enrollment questionnaires included Rome III Diagnostic Questionnaire Symptom Severity Scale. Then, 185 meeting criteria for rated (using Bristol Stool Scale) each movement (BM) 90 days whether BM was accompanied pain, urgency, or soiling....
Hirshfeld atom refinement (HAR) is a novel X-ray structure technique that employs aspherical atomic scattering factors obtained from stockholder partitioning of theoretically determined tailor-made static electron density. HAR overcomes many the known limitations independent modelling (IAM), such as too short element-hydrogen distances, r(X-H), or large displacement parameters (ADPs). This study probes accuracy and precision anisotropic hydrogen non-hydrogen ADPs r(X-H) values HAR. These...
This study investigated if inositol in a combination of myo-inositol and D-chiro-inositol would prevent gestational diabetes mellitus (GDM) women with family history diabetes.This was randomized controlled trial that examined whether from the first antenatal visit prevents GDM. The carried out single-center tertiary referral center. Women were enrolled at visit. They to intervention group, which received 1,100 mg myo-inositol, 27.6 D-chiro-inositol, 400 μg folic acid, or control acid only....