About
Contact & Profiles
A5058300972
Research Areas
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Ion channel regulation and function
Tufts University
2021
First-in-line benzodiazepine treatment fails to terminate seizures in about 30% of epilepsy patients, highlighting a need for novel anti-seizure strategies. It is emerging that impaired K+/Cl- cotransporter 2 (KCC2) activity leads deficits GABAergic inhibition and increased seizure vulnerability patients. In neurons, the with-no-lysine (WNK) kinase-STE20/SPS1-related proline/alanine-rich (SPAK) kinase signalling pathway inhibits KCC2 via T1007 phosphorylation. Here, we exploit selective WNK...
10.1093/brain/awab343
article
EN
Brain
2021-09-10
Coming Soon ...