A5083502730- Biochemical and Structural Characterization
- Force Microscopy Techniques and Applications
- Urban, Neighborhood, and Segregation Studies
- Nanomaterials for catalytic reactions
- Antimicrobial Peptides and Activities
- Protein Structure and Dynamics
- Synthesis and Biological Evaluation
- DNA and Nucleic Acid Chemistry
- Click Chemistry and Applications
- Enzyme Structure and Function
- Crystallization and Solubility Studies
- Chemical Synthesis and Analysis
- RNA and protein synthesis mechanisms
- Nuclear Structure and Function
- Crystallography and molecular interactions
- Nanocluster Synthesis and Applications
- Multicomponent Synthesis of Heterocycles
- Neuropeptides and Animal Physiology
- X-ray Diffraction in Crystallography
- Receptor Mechanisms and Signaling
- Gold and Silver Nanoparticles Synthesis and Applications
- Monoclonal and Polyclonal Antibodies Research
Heinrich Heine University Düsseldorf
2016-2023
University of Regensburg
2020
Wright State University
1982
3-Aminovinylquinoxalines are readily accessible from (hetero)aryl glyoxylic acids or heterocyclic π-nucleophiles by consecutive four- and five-component syntheses in the sense of an activation-alkynylation-cyclocondensation-addition sequence glyoxylation-alkynylation-cyclocondensation-addition good yields. The title compounds highly fluorescent with pronounced emission solvatochromicity protochromic fluorescence quenching. Time-resolved spectroscopy furnishes radiative nonradiative decay...
Ultrasmall gold nanoparticles (diameter about 2 nm) were surface-functionalized with cysteine-carrying precision macromolecules. These consisted of sequence-defined oligo(amidoamine)s (OAAs) either two or six cysteine molecules for binding to the surface and without a PEG chain (3400 Da). They characterized by 1 H NMR spectroscopy, diffusion-ordered spectroscopy (DOSY), small-angle X-ray scattering (SAXS), high-resolution transmission electron microscopy. The number macromolecules per...
Survivin, a well-known member of the inhibitor apoptosis protein family, is upregulated in many cancer cells, which associated with resistance to chemotherapy. To circumvent this, inhibitors are currently being developed interfere nuclear export survivin by targeting its protein–protein interaction (PPI) receptor CRM1. Here, we combine for first time supramolecular tweezer motif, sequence-defined macromolecular scaffolds, and ultrasmall Au nanoparticles (us-AuNPs) tailor high avidity...
Many natural proteins contain flexible loops utilizing well-defined complementary surface regions of their interacting partners and usually undergo major structural rearrangements to allow perfect binding. The molecular recognition such structures is still highly challenging due the inherent conformational dynamics. Notably, protein-protein interactions are on other hand characterized by a multivalent display binding enhance affinity specificity. Imitating this concept, we here report...
This study aims at quantifying the steric shielding effect of multivalent glycoconjugates targeting pathogens by blocking their carbohydrate binding sites. Specifically, PEGylated and non-PEGylated are studied as inhibitors lectins bacterial adhesins evaluating repulsion nonbinding PEG chains. We use soft colloidal probe (SCP) adhesion assay to monitor change in energy mannose (Man)-decorated hydrogel particles on a layer concanavalin A (ConA) presence sequence-defined glycoconjugate over...
This research investigates the influence of a suburban lifestyle upon attitudes women. Specifically, sample women are interviewed and information is ascertained concerning their toward commercial social isolation in suburbia. Additionally, demographic data acquired from order to describe compare it female population that has previously been researched.
The recently resolved crystal structure of the neuropeptide Y Y1 receptor (Y1R), co-crystallized with high-affinity (pKi: 10.11), argininamide-type Y1R antagonist UR-MK299 (2), revealed that Nω-carbamoyl substituent (van der Waals volume: 139 Å3) is deeply buried in receptor, occupying a hydrophobic pocket. We synthesized and characterized series argininamides, structurally related to 2. affinity decreased increasing size carbamoyl residue (minimal pKi: 5.67). Exceeding critical 212 Å3),...