A5073298614- Effects and risks of endocrine disrupting chemicals
- Asthma and respiratory diseases
- Hypothalamic control of reproductive hormones
- Adipose Tissue and Metabolism
- Ovarian function and disorders
- Respiratory and Cough-Related Research
- Reproductive Physiology in Livestock
- Microplastics and Plastic Pollution
- Regulation of Appetite and Obesity
- Growth Hormone and Insulin-like Growth Factors
- Peroxisome Proliferator-Activated Receptors
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Pharmacological Effects and Assays
- Biochemical effects in animals
- Neuropeptides and Animal Physiology
- Immune Cell Function and Interaction
- Sirtuins and Resveratrol in Medicine
- Recycling and Waste Management Techniques
- Food Allergy and Anaphylaxis Research
- Birth, Development, and Health
- Immunodeficiency and Autoimmune Disorders
- IL-33, ST2, and ILC Pathways
- Estrogen and related hormone effects
- Marine Biology and Ecology Research
Universidad de Salamanca
2025
Experimental Medicine and Biology Institute
2009-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2006-2024
National University of Comahue
2024
Universidade de São Paulo
2023
University of Buenos Aires
2005-2022
Centro Científico Tecnológico - San Juan
2020
University of California, San Diego
2011-2019
VA San Diego Healthcare System
2011-2018
Connecticut Children's Medical Center
2016-2017
Bisphenol A (BPA), an endocrine disruptor, is a component of polycarbonate plastics, epoxy resins, and polystyrene. Several studies have reported potent in vivo effects, because BPA behaves as estrogen agonist and/or antagonist androgen thyroid hormone antagonist.We investigated the effects neonatal exposure to on reproductive axis adult female Sprague-Dawley rats.Female rats were injected subcutaneously, daily from postnatal day 1 (PND1) PND10 with castor oil at 500 microg/50 microL...
Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins, and polystyrene found in many products. Several reports have revealed potent vivo effects, because BPA acts as an estrogen agonist and/or antagonist androgen thyroid hormone antagonist.We analyzed the effects neonatal exposure to on reproductive axis female Sprague-Dawley rats.Female rats were injected subcutaneously, daily, from postnatal day 1 (PND1) PND10 with [500 microg/50 microL (high) or 50 (low)] castor oil...
The ubiquitous and global ecological footprint arising from the rapidly increasing rates of plastic production, use, release into environment is an important modern environmental issue. Of concern are risks associated with at least 16,000 chemicals present in plastics, some which known to be toxic, may leach out both during use once exposed conditions, leading human exposure. In response, United Nations member states agreed establish international legally binding instrument on pollution,...
This study was designed to further ascertain the presence in plasma of lipoprotein lipase (LPL) bound circulating lipoproteins. Lipoprotein mass and activity values preheparin from 20 volunteers were 69.8 +/- 6.6 ng.ml-1 1.54 0.15 mU.ml-1, respectively, no significant correlation between observed. Fifteen min after heparin injection, LPL had increased 536 60 261 34 mU.ml-1 a highly increments The released material specific 0.57 0.03 mU.ng-1. eluted early heparin-Sepharose, position expected...
Gonadotropin synthesis and release is dependent on pulsatile stimulation by the hypothalamic neuropeptide GnRH. Generally, slow GnRH pulses promote FSH production, whereas rapid favor LH, but molecular mechanism underlying this pulse sensitivity poorly understood. In study, we developed tested a model for FSHβ regulation in mouse LβT2 gonadotropes. By mining previous microarray data set, found that mRNA positive regulators of Fshb expression, such as Fos Jun, were up-regulated at slower...
Human norovirus (NoV) outbreak investigations suggest that the hands of infected individuals play an important role in NoV transmission. However, there is no experimental evidence documenting likelihood and degree contamination on hands. As part a clinical trial designed to evaluate efficacy high-pressure processing for Norwalk virus (NV) inactivation oysters, 159 hand rinse samples were collected from 6 uninfected subjects. NV was concentrated by polyethylene glycol precipitation, followed...
Female obesity is associated with insulin resistance, hyperandrogenemia, and reproductive dysfunction. We hypothesized that elevated free fatty acids (FFAs) might directly modulate pituitary gonadotropin production. FFAs caused a time- dose-dependent increase in phosphorylation of the MAPKs p38MAPK, c-Jun N-terminal kinase (JNK)-1/2, ERK1/2 LβT2 gonadotrope cells. Furthermore, up-regulated Lhb mRNA expression acutely, an effect was blocked by JNK inhibition, but suppressed Fshb expression,...
Abstract The ongoing international negotiations on a global plastics treaty will have pivotal implications for future efforts to transform the plastic economy. This is essential since current use of in economy impacts environment beyond planetary carrying capacity. To ensure that forthcoming Treaty can provide foundation this transition, best available science must be made negotiations, but with no formal scientific mechanism inform process, not ensured. Scientists’ Coalition an Effective...
Abstract Sirtuin 1 (Sirt1) is an NAD-dependent class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, evidence suggests SIRT1 neurons plays role the central regulation of balance and reproduction, but no studies have addressed contribution astrocytes. We show here overexpression astrocytes causes markedly increased food intake, body weight gain, glucose intolerance, expression deacetylase-deficient mutant...
Aim: This study investigates the association between ApoE genotype, plasma cholesteryl ester (CE) levels, and Alzheimer’s disease (AD) status, with a focus on CE(20:4) CE(22:5) levels as potential indicators of lipid metabolism alterations in AD patients. Methods: Publicly available metabolomics data (DOI: 10.3233/JAD-215448) from 94 patients 62 controls aged 55 older were re-analyzed. CE examined using non-parametric tests due to non-normal overall distribution. Comparisons stratified by...
Eosinophilic esophagitis (EoE) is treated with dietary modification and/or pharmacologic management swallowed topical steroids. Swallowed fluticasone propionate (FP) and oral viscous budesonide (OVB) have proven to be effective in resolving symptoms reversing histologic changes children adults EoE. There are minimal comparative studies between the 2 agents.The aim of study was retrospectively compare endoscopic outcomes after FP versus OVB therapy EoE our center.We performed a retrospective...
Eosinophilic esophagitis (EoE) is an emerging allergic, IgE- and non-IgE (Th2 cell)-mediated disease. There are major gaps in the understanding of basic mechanisms that drive persistence EoE. We investigated whether esophageal biopsies from children with EoE demonstrate inflammatory response distinct normal controls. prospectively enrolled 84 patients, whom 77 were included our analysis, aged 4-17 years (12.8±3.8 years; 81% males). Five collected each patient at time endoscopy. Intramucosal...
The peroxisome-proliferator activated receptor γ (PPARγ) is expressed in the hypothalamus areas involved energy homeostasis and glucose metabolism. In this study, we created a deletion of PPARγ brain-knockout (BKO) mature neurons female mice to investigate its involvement metabolism reproduction. We observed that there was no difference age at puberty onset between BKOs littermate controls, but gave smaller litters when mated fewer oocytes ovulated. BKO had regular cycles showed an increase...
Benthic sampling was carried out in the Patagonian shrimp (Pleoticus muelleri Bate, 1888) fishing grounds San Jorge Gulf, Argentina, order to determine composition, spatial distribution and relative abundance of species benthic communities. Biological samples were taken with an epibenthic sledge 66 stations, 57 sediment for granulometric analysis a Picard dredge. A total 135 taxa from communities identified. Cluster Analyses (Q R modes) applied using Fager (Fager McGowan, 1963) Czekanowski...
Mice lacking peroxisome-proliferator activated receptor-γ (PPARγ) in neurons do not become leptin resistant when placed on a high-fat diet (HFD). In male mice, this results decreased food intake and increased energy expenditure, causing reduced body weight, but difference weight is observed female mice. addition, estrous cycles are disturbed the ovaries present with hemorrhagic follicles. We that PPARγ was more highly expressed astrocytes than neurons, so we created an inducible, conditional...
Background: We have demonstrated that the administration of δ-iodolactone (i.e., 5-iodo-delta lactone) arachidonic acid (IL-δ), a mediator in thyroid autoregulation, prevents goiter induction by methylmercaptoimidazol (MMI) rats. Other studies shown transforming growth factor beta-1 (TGF-β1) mimics some actions excess iodide, but its participation autoregulation is disputed. The present were performed to test hypotheses IL-δ decreases inhibition cell proliferation and/or stimulation...
Summary CD160/BY55 is a glucosyl-phosphatidylinositol (GPI)-anchored cell membrane receptor that expressed primarily in natural killer (NK) cells. Its presence CD8+ T lymphocytes considered to be marker of cytotoxic activity, although there are few data this regard. In the present work, we analysed expression CD160 subpopulations cytomegalovirus (CMV)-specific Subpopulations were defined by CD28 and CD57 exhibited varying degrees differentiation potential, as evaluated perforin, interferon...
Sirt1 is an NAD-dependent, class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emerging evidence suggests neuronal activity plays role the central regulation of balance and glucose metabolism. this study, we generated mice expressing enzymatically inactive form (N-MUT) or wild-type (WT) SIRT1 (N-OX) mature neurons. N-OX male female had impaired tolerance, N-MUT female, but not male, improved tolerance compared...