A5066312600- Immune cells in cancer
- Telomeres, Telomerase, and Senescence
- Parasitic Diseases Research and Treatment
- Immune Response and Inflammation
- Advanced biosensing and bioanalysis techniques
- Free Radicals and Antioxidants
- Tryptophan and brain disorders
- Renal Transplantation Outcomes and Treatments
- Computational Drug Discovery Methods
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Prion Diseases and Protein Misfolding
- RNA Interference and Gene Delivery
- Insect symbiosis and bacterial influences
- Technology Adoption and User Behaviour
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Organic Chemistry Cycloaddition Reactions
- Parasites and Host Interactions
- Long-Term Effects of COVID-19
- Effects of Vibration on Health
- COVID-19 and Mental Health
- COVID-19 Pandemic Impacts
- RNA regulation and disease
- Organ Transplantation Techniques and Outcomes
- Bioactive natural compounds
Symbiosis International University
2022-2025
Central Drug Research Institute
2009-2024
Academy of Scientific and Innovative Research
2014-2024
Institute of Genomics and Integrative Biology
2012-2024
Central Institute of Medicinal and Aromatic Plants
2023-2024
Chandigarh University
2021-2024
Czech Academy of Sciences, Institute of Biotechnology
2024
Tata Institute of Fundamental Research
2024
National Centre for Biological Sciences
2024
All India Institute of Medical Sciences
2023
Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation hTERT maintains and triggers progression >90% cancers. However, any direct causal link between regulation unclear. Here, we show that the telomere-repeat-binding-factor 2 (TRF2) binds promoter G-quadruplexes recruits polycomb-repressor EZH2/PRC2 complex. This is for H3K27 trimethylation at represses cancer as...
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with aggregation of TAR DNA-binding protein-43 (TDP-43) in neuronal cells and manifests as motor neuron dysfunction & muscle atrophy. The carboxyl-terminal prion-like domain TDP-43 can aggregate vitro into toxic β-sheet rich amyloid-like structures. So far, treatment options for ALS are very limited Riluzole, which targets glutamate receptors, the only but highly ineffective drug. Therefore,...
Small molecules with antioxidative properties have been implicated in amyloid disorders. Curcumin is the active ingredient present turmeric and known for several biological medicinal effects. Adequate evidence substantiates importance of curcumin Alzheimer's disease recent suggests its role Prion Parkinson's disease. However, contradictory effects suggested Huntington's This difference provided a compelling reason to investigate effect on glutamine-rich (Q-rich) non-glutamine-rich (non...
Background: Over-expression of Vascular Endothelial Growth Factor Receptors (VEGFRs) leads to the hyperactivation oncogenes. For inhibition this hyperactivation, USA Food Drug Administration (FDA) has approved many drugs that show adverse effects, such as hypertension, hypothyroidism, etc. There is a need discover potent natural compounds minimal side effects. In present study, we have taken structurally diverse known VEGFR2 inhibitors develop Quantitative Structure-Activity Relationship...
Abstract Within the context of Molecular Electronic Density Theory (MEDT), this study investigates Diels–Alder reaction among isoprene ( 2 ) and R-carvone 1R applying DFT simulations, with without Lewis acid (LA) catalysis. The results show that carvone acts as an electrophile a nucleophile in polar process. LA catalysis increases electrophilicity carvone, thereby improving reactivity selectivity by reducing activation Gibbs free energy. Parr functions reveal C 5 =C 6 double bond is more...
Wolbachia, an endosymbiont of filarial nematode, is considered a promising target for treatment lymphatic filariasis. Although functional characterization the Wolbachia peptidoglycan assembly has not been fully explored, genome provides evidence coding all genes involved in lipid II biosynthesis, part biosynthesis pathway. UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) one pathway enzymes and it inevitably recognized as antibiotic target. In view vital role MurA bacterial viability...
Mutations in the superoxide dismutase (SOD1) gene account for ∼15% and transactive response DNA binding protein (TARDBP) ∼5% of familial amyotrophic lateral sclerosis (FALS) cases. These two genes were analysed siblings from North India with ALS a positive family history. The coding region SOD1 TARDBP was sequenced both siblings. Genetic variation identified typed unaffected members (n = 11), sporadic patients 48) healthy controls 35). Molecular dynamic (MD) simulations performed on...
Lymphatic filariasis leads to profound impairment of parasite-specific T helper type 1 (Th1) and Th2 immune responses significantly increases the expression regulatory networks effectors like transforming growth factor-β, CD25, cytotoxic T-lymphocyte antigen 4, glucocorticoid-induced tumour necrosis factor receptor (GITR) (Treg) cells, which together play an important role in immunosuppression. While Treg cells suppress activity effector monocyte dysfunction, characterized by alternatively...
Wolbachia is an endosymbiotic bacterium of the filarial nematode Brugia malayi. The symbiotic relationship between and its host dependent on interactions proteins both organisms. However, little known about that are involved in inflammatory pathology during lymphatic filariasis. In present study, we cloned, expressed purified surface protein (r-wsp) from administered it to mice, either alone or combination with infective larvae B. malayi (Bm-L3) monitored developing immune response infected...
Moxidectin is a macrocyclic lactone belonging to milbemycin family closely related ivermectin and currently progressing towards Phase III clinical trial against human infection with the filaria Onchocerca volvulus (Leuckart, 1894). There single report on microfilaricidal embryostatic activity of moxidectin in case lymphatic filarial parasite Brugia malayi (Brug, 1927) Mastomys coucha (Smith) but without any adulticidal action. In present study, vitro vivo antifilarial efficacy was evaluated...