A5013289001- Head and Neck Cancer Studies
- Occupational and environmental lung diseases
- Esophageal Cancer Research and Treatment
- Palliative Care and End-of-Life Issues
- Fibroblast Growth Factor Research
- Peptidase Inhibition and Analysis
- Head and Neck Surgical Oncology
- Carcinogens and Genotoxicity Assessment
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Research Studies
- Polyomavirus and related diseases
- Cancer-related molecular mechanisms research
- Ear and Head Tumors
- Air Quality and Health Impacts
- S100 Proteins and Annexins
- Tracheal and airway disorders
- Proteoglycans and glycosaminoglycans research
- Reconstructive Facial Surgery Techniques
- Nonmelanoma Skin Cancer Studies
- Pancreatic and Hepatic Oncology Research
- TGF-β signaling in diseases
- Cancer survivorship and care
- RNA Interference and Gene Delivery
- Antenna Design and Analysis
- Hepatitis B Virus Studies
Helsinki University Hospital
2017-2025
University of Helsinki
2017-2025
Objectives: Oropharyngeal squamous cell carcinoma (OPSCC) is divided in two different disease entities depending on HPV involvement. We investigated differences presenting symptoms and clinical findings patients with HPV-positive -negative OPSCC tumors.Methods: Altogether 118 consecutive diagnosed primary between 2012 2014 at the Helsinki University Hospital were included. HPV-status of tumors was assessed by PCR detection DNA immunostaining p16-INK4a antibody.Results: Fifty-one (47.7%) had...
Abstract Background The etiological role of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OPSCC) is confirmed. However, the other oncoviruses OPSCC unknown. Materials and methods A total 158 consecutive patients treated with curative intent were included. DNA extracted from tumor sections was used to detect Epstein–Barr virus (EBV), HPV, following polyomaviruses: John Cunningham (JCV), Simian 40 (SV40), BK (BKV) PCR. In addition, p16 expression studied by...
Abstract Purpose The aim of this nationwide retrospective cohort study was to evaluate the timing first specialist palliative care (SPC) contact and its impact on use hospital resources at end life in patients with brain tumors. Materials methods analysis comprised 373 tumor who died during 2019 Finland. Patients were divided into two groups according time SPC contact: early, i.e. more than 30 days before death, late, no or less death. Results 216 (58%) male, a mean age 67 years (range...
<title>Abstract</title> Background and purpose Esophageal gastric cancer patients, with poor prognoses complex symptom burdens, require comprehensive end-of-life care. This study evaluated the impact of specialist palliative care (SPC) on healthcare utilization. Material methods We retrospectively analyzed nationwide utilization data for all adults who died esophageal or in Finland 2019, using National Health Social Care Registers. Patients were compared based timing first SPC contact: early...
The end of life patients with head and neck cancer (HNC) is plagued by significant morbidity high symptom burden, emphasizing the need for palliative care. Our aim was to evaluate utilization health care services, including specialist (SPC), among HNC at life. In addition, we wanted explore timing SPC contact on services study population consisted all 281 who died in 2019 Finland. Data were collected from nationwide registries. Patients divided into two groups according their first an unit:...
Abstract Non-malignant diseases cause 60% of non-communicable requiring palliative care, yet specialist care services primarily focus on cancer. We investigated end-of-life healthcare and social utilization among cancer non-malignant patients, and, secondarily, access to its effect utilization. This retrospective, nationwide register-based study included all adults (n = 38 540) who died from life-limiting in Finland 2019, categorized into neurodegenerative (31%), other (36%), (33%) groups....
Abstract Background and purpose Esophageal gastric cancer patients, with poor prognoses complex symptom burdens, require comprehensive end-of-life care. This study evaluated the impact of specialist palliative care (SPC) on healthcare utilization. Material methods We retrospectively analyzed nationwide utilization data for all adults who died esophageal or in Finland 2019, using National Health Social Care Registers. Patients were compared based timing first SPC contact: early (> 30 days...
Cisplatin is combined with radiotherapy for advanced head and neck squamous cell carcinoma (HNSCC). While providing a beneficial effect on survival, it also causes side effects thus an important target when considering treatment de-escalation. Currently, there are no biomarkers to predict its patient-selective therapeutic utility. In this study, we examined the role of stem factor OCT4 as potential biomarker help clinicians stratify HNSCC patients between chemoradiotherapy....
Background and purpose: Changes in treatment approaches, characterised by the shift from laryngectomy to a focus on organ-preserving methods may have potentially resulted lower survival. We aim identify differences survival trends for laryngeal cancer (LC) Nordic countries over period of 50 years, discuss potential impact factors such as changes protocols. Materials methods: Five-year relative (RS) data 1972 2021 were obtained NORDCAN database 2.0 which included 33,692 LC cases, 85%...
An emerging subset of oropharyngeal squamous cell carcinomas (OPSCC) is caused by HPV. HPV-positive OPSCC has a better prognosis than HPV-negative OPSCC, but other prognostic markers for these two different diseases are scarce. Our aim was to evaluate serum levels and tumor expression matrix metalloproteinase-8 (MMP-8) tissue inhibitor metalloproteinase-1 (TIMP-1) assess their role in OPSCC. A total 90 consecutive patients diagnosed treated with curative intent at the Helsinki University...
Approximately 20% of cancers are estimated to have a viral etiology. We aimed investigate whether DNA 8 human parvoviruses [bocavirus 1-4 (HBoV1-4), parvovirus B19 (B19V), protoparvoviruses (bufa-, tusa-, and cutavirus)] 13 polyomaviruses (HPyV) can be detected in oropharyngeal oral cavity squamous cell carcinoma (OPSCC/OSCC), juvenile nasopharyngeal angiofibroma (JNA) tissue samples.Fresh samples seven JNA tissues ten paired OSCC/OPSCC tumor adjacent healthy were collected. extraction...
Background The surrogate immunohistochemical marker, p16INK4a, is used in clinical practice to determine the high-risk human papillomavirus (HPV) status of oropharyngeal squamous cell carcinomas (OPSCC). With a specificity 83%, this will misclassify some patients compared with direct HPV testing. Patients who are p16INK4a-positive but DNA-negative, or RNA-negative, may be unsuitable for treatment de-escalation aimed at reducing treatment-related side effects. We identify cost-effective serum...
The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is mainly related to human papillomavirus (HPV) infection. As OPSCCs are often diagnosed at an advanced stage, mortality and morbidity remain high. There no diagnostic biomarkers for early detection OPSCC.Serum from 25 patients with stage I-II OPSCC, 12 healthy controls, was studied quantitative label-free proteomics using ultra-definition MSE. Statistical analyses were performed identify the proteins most reliably...
Biomarkers are not broadly used in the management of head and neck cancers (HNCs). have been beneficial other cancers, however, HNCs. Therefore, we observed immunopositivity a novel biomarker called immunoglobulin superfamily member 3 (IGSF3) tumor tissues HPV‐related HPV‐unrelated OPSCC. Two patient cohorts (C1 C2) from separate time periods were available for this study (total N = 282). Both consisted OPSCC patients treated at Helsinki University Hospital (HUS, Helsinki, Finland) during...
Abstract The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is primarily due to human papillomavirus, and understanding the tumor biology caused by virus crucial. Our goal was investigate proteins present in serum patients with OPSCC, which were not previously studied OPSCC tissue. We examined difference expression these between HPV-positive -negative tumors their correlation clinicopathological parameters patient survival. study included 157 formalin-fixed,...
The impact of societal factors on the occurrence head and neck cancers (HNCs) remains understudied, especially in Nordic countries.
Protein glycosylation responds sensitively to disease states. It is implicated in every hallmark of cancer and has recently started be considered as a itself. Changes N-glycosylation microheterogeneity are more dramatic than those protein expression due the non-template nature glycosylation. This enables their potential use serum-based diagnostics. Here, we perform glycopeptidomics on serum from patients with oropharyngeal squamous cell carcinoma (OPSCC), compared controls comparing between...
Abstract Purpose Evaluate the occupational variation in incidence of oropharyngeal cancer (OPC). Methods We calculated standardized ratios (SIRs) OPC categories Nordic countries relative to entire national populations. The data covered 6155 cases. Results Among men high risk was observed, among else, waiters (SIR 6.28, 95% CI 4.68–8.26), beverage workers 3.00, 1.72–4.88), and artistic 2.97, 2.31–3.76). women observed 2.02, 1.41–2.81) packers 1.73, 1.07–2.64). lowest SIRs were female...