A5005531676- Marine Toxins and Detection Methods
- Marine and coastal ecosystems
- Microbial Community Ecology and Physiology
- Protist diversity and phylogeny
- Insect-Plant Interactions and Control
- Agricultural pest management studies
- Marine Biology and Ecology Research
- Insect Resistance and Genetics
- Nutrition, Genetics, and Disease
- Acute Myeloid Leukemia Research
- Insect Pest Control Strategies
- Hematopoietic Stem Cell Transplantation
- Genetic Associations and Epidemiology
- Agricultural Economics and Practices
- Weed Control and Herbicide Applications
- Parasite Biology and Host Interactions
- Genetic and phenotypic traits in livestock
- Agricultural Science and Fertilization
- Identification and Quantification in Food
- Epigenetics and DNA Methylation
- Entomological Studies and Ecology
- Agricultural Practices and Plant Genetics
- Insect behavior and control techniques
- Diatoms and Algae Research
- Oil Spill Detection and Mitigation
University of Technology Sydney
2016-2024
Central Institute for Arid Horticulture
2021-2023
Jamia Millia Islamia
2021
Prince of Wales Hospital
2017
UNSW Sydney
2014-2017
Cancer Institute of New South Wales
2015-2017
Ealing Hospital
2017
Ealing Hospital NHS Trust
2017
Maharana Pratap University of Agriculture and Technology
2017
Central Institute For Subtropical Horticulture
2004
Myelodysplastic syndromes and chronic myelomonocytic leukemia are blood disorders characterized by ineffective hematopoiesis progressive marrow failure that can transform into acute leukemia. The DNA methyltransferase inhibitor 5-azacytidine (AZA) is the most effective pharmacological option, but only ∼50% of patients respond. A response manifests after many months treatment transient. reasons underlying AZA resistance unknown, few alternatives exist for non-responders. Here, we show...
Gambierdiscus is a genus of benthic dinoflagellates found worldwide. Some species produce neurotoxins (maitotoxins and ciguatoxins) that bioaccumulate cause ciguatera fish poisoning (CFP), potentially fatal food-borne illness common worldwide in tropical regions. The investigation toxigenic CFP endemic regions Australia necessary as first step to determine which are related cases occurring this region. In study, we characterized five strains collected from Heron Island, Australia, region...
An expedition to North Meyer Island, Kermadec Islands, in November 2015, resulted the isolation of two Gambierdiscus species, G. australes and a previously unknown species maintained Cawthron Institute Culture Collection Micro-algae as CAWD242. Identifications were based on morphology DNA sequence data analysis. Nine isolates produced maitotoxin-1 (MTX-1) ranging from present (detectable but below confidence level) 36.6 pg per cell. One further isolate did not produce MTX-1, all putative...
The cytidine analogue, 5-azacytidine (AZA; 5-AZA-cR), is the primary treatment for myelodysplastic syndrome and chronic myelomonocytic leukaemia. However, only ~50% of treated patients will respond to AZA drivers resistance in vivo are poorly understood. To better understand intracellular dynamics upon therapy decipher molecular basis resistance, we have developed a novel, multiparameter, quantitative mass spectrometry method (AZA-MS). Using AZA-MS, accurately quantified abundance...
Black gram is a key pulse crop in India, known for its nutritional value and role improving soil fertility via nitrogen fixation. However, organic farming alone cannot meet the growing food demand. This study evaluated integrated nutrient management (INM) combining biofertilizers with inorganic inputs to boost yield health. A field trial was conducted during Kharif 2023 2024 at Acharya Narendra Deva University, Ayodhya, Uttar Pradesh, India. The followed factorial randomized block design...
A new species belonging to the toxin producing diatom genus Pseudo-nitzschia, P. hallegraeffii sp. nov., is delineated and described from East Australian Current (EAC). Clonal cultures were established by single cell isolation phytoplankton net hauls collected as part of a research expedition in EAC region 2016 on RV Investigator. Cultures assessed for their morphological genetic characteristics, sexual compatibility with other Pseudo-nitzschia species, ability produce domoic acid. Light...
Ciguatera fish poisoning (CFP) is an illness contracted through the ingestion of seafood containing ciguatoxins. It prevalent in tropical regions worldwide, including Australia. Ciguatoxins are produced by some species Gambierdiscus. Therefore, screening Gambierdiscus identification quantitative PCR (qPCR), along with determination toxicity, can be useful monitoring potential ciguatera risk these regions. In Australia, CFP Queensland and increasingly sub-tropical but has a report rate...
Summary Ostreopsis is a genus of dinoflagellates that includes species producing palytoxin and structurally related compounds. The distribution in Australia largely unknown, but they have been reported from north Queensland (18 ° S) to Tasmania (41–43 S). spp. recurrently estuaries around New South Wales, with persistent occurrences Merimbula Lake inlet throughout the year. We isolated characterized strain cf . siamensis using light scanning electron microscopy as well molecular sequences...
Summary In marine ecosystems, dinoflagellates can become highly abundant and even dominant at times, despite their comparatively slow growth. Their ecological success may be related to production of complex toxic polyketide compounds. Ostreopsis species produce potent palytoxin‐like compounds (PLTX), which are associated with human skin eye irritations, illnesses through the consumption contaminated seafood. To investigate genetic basis PLTX‐like compounds, we sequenced annotated...
SUMMARY Certain species of the marine diatom genus Pseudo‐nitzschia are responsible for production domoic acid (DA), a neurotoxin that can bioaccumulate in food chain and cause amnesic shellfish poisoning (ASP) animals humans. This study extends our knowledge by reporting on first observation potentially toxic simulans from this region. One clonal strain P. was isolated East Australian Current characterized using light transmission electron microscopy, phylogenetic analyses based regions...
Abstract Genetic diversity in marine microbial eukaryotic populations (protists) drives their ecological success by enabling diverse phenotypes to respond rapidly changing environmental conditions. Despite enormous population sizes and lack of barriers gene flow, genetic differentiation that is associated with geographic distance, currents, gradients has been reported from planktonic protists. However, for benthic protists, which have reduced dispersal opportunities, phylogeography its...
Approximately 70 species of Prorocentrum are known, which around 30 associated with benthic habitats. Some produce okadaic acid (OA), dinophysistoxin (DTX) and their derivatives, involved in diarrhetic shellfish poisoning. In this study, we isolated characterized concavum P. malayense from Broome north Western Australia using light scanning electron microscopy as well molecular sequences large subunit regions ribosomal DNA, marking the first record these Australian waters. The morphology...
Abstract Despite their relatively high thermal optima ( T opt ), tropical taxa may be particularly vulnerable to a rising baseline and increased temperature variation because they live in stable temperatures closer . We examined how microbial eukaryotes with differing histories responded fluctuations of different amplitudes (0 control, ±2, ±4°C) around mean below or above Cosmopolitan dinoflagellates were selected based on distinct traits included two species the same genus (tropical...
Abstract It is important to decipher the diversity and distribution of benthic dinoflagellates, as there are many morphologically indistinct taxa that differ from one another in production potent toxins. To date, genus Ostreopsis comprises twelve described species, which seven potentially toxic produce compounds presenting a threat human environmental health. In this study, isolates previously identified “ sp. 3” were sampled area where it was first reported, Rarotonga, Cook Islands, have...