A5085392521- Neutropenia and Cancer Infections
- Breast Cancer Treatment Studies
- Intraperitoneal and Appendiceal Malignancies
- Breast Lesions and Carcinomas
- Lymphoma Diagnosis and Treatment
- Breast Implant and Reconstruction
- Mesenchymal stem cell research
- Immune cells in cancer
- Global Cancer Incidence and Screening
- Actinomycetales infections and treatment
- Cancer Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Fungal Infections and Studies
- Reconstructive Surgery and Microvascular Techniques
- Antifungal resistance and susceptibility
- CNS Lymphoma Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Appendicitis Diagnosis and Management
- Advanced Biosensing Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Political Theory and Influence
- Legal and Regulatory Analysis
- Cancer Cells and Metastasis
- Hospital Admissions and Outcomes
- Brain Metastases and Treatment
Wellington Hospital
2023
Brooke Army Medical Center
2009-2022
Orthopaedic Center
2021
Westmead Hospital
2017-2019
Sydney Hospital
2019
University of North Carolina at Chapel Hill
2019
Liverpool Hospital
2018
San Antonio Uniformed Services Health Education Consortium
2017
Cancer Institute of New South Wales
2017
Wilford Hall Ambulatory Surgical Center
2016
Abstract Traditional antibody optimization approaches involve screening a small subset of the available sequence space, often resulting in drug candidates with suboptimal binding affinity, developability or immunogenicity. Based on two distinct antibodies, we demonstrate that deep contextual language models trained high-throughput affinity data can quantitatively predict unseen variants. These variants span K D range three orders magnitude over large mutational space. Our reveal strong...
477-487) has revealed several differences in their properties.Among these are alterations the heat stability, divalent cation requirement, pH optimum, 3'-5'-single strand exonuclease activity, and DNAdependent conversion of a deoxynucleoside triphosphate to its corresponding monophosphate ("turnover").The decrease 3'-single turnover indicate defect editing function mutD strain, which is at least part responsible €or high spontaneous mutation rate mutD.Transformation by hybrid plasmid, pRD3,...
The main surgical options for treatment of breast cancer are breast-conserving surgery and mastectomy. BCS aims to achieve complete excision the tumor while achieving a pleasing cosmetic result. Excision tumors in lateral aspect has been associated with issues such as contour deformities asymmetry. Development volume replacement techniques intercostal artery perforator flap (LICAP) aimed address these issues. Our modification traditional LICAP offers less visible scar, good access axilla, no...
Recent guidance advocates daily consultant-led ward rounds, conducted in the morning with presence of senior nursing staff and minimising patients on outlying wards. These recommendations aim to improve patient management through timely investigations, treatment discharge. This study sought evaluate current surgical round practices England.Information regarding timing staffing levels rounds was collected prospectively over a one-week period. The location each also documented. Two trainee...
Autoimmune neutropenia is a rare side effect of nivolumab which may respond to antibody-based therapies.Nivolumab can lead durable complete remission in primary mediastinal B-cell lymphoma refractory multiple lines therapy.
Abstract EVs released by adipose derived stem cells (ADSCs) have shown promise as a therapeutic for tissue repair because of their purported immune‐regulatory properties. Extracellular vesicles (EVs) from ADSCs could be beneficial in improving graft retention rates autologous fat grafting (AFG) post‐mastectomy as, currently, grafted are variable. Enriching with ADSC‐EVs may improve modulating macrophages resident within both the breast and lipoaspirate. We aimed to identify key macrophage...
Non-Hodgkin lymphomas (NHLs) are a heterogeneous group of hematologic malignancies which typically respond to standard first-line chemoimmunotherapy regimens. Unfortunately, patients with refractory NHL face poor prognosis and represent an unmet need for improved therapeutics. We present two cases CD30+ who responded novel brentuximab vedotin- (BV-) based The first is patient stage IV anaplastic large cell lymphoma (ALCL) cranial nerve involvement failed front-line treatment...
Infections remain a significant cause of mortality in hematopoietic stem cell transplant patients. Evaluations causes infection are often unrevealing, and at some sites, increasing rates antimicrobial resistance have been noticed. We performed retrospective analysis microbiologic testing yield, or percent tests ordered to diagnose an infection, the first 100 days 30 allogeneic 56 autologous transplants San Antonio Military Medical Center from July 2011 April 2014. Blood stream infections...
Appendiceal diseases are rare reported complications during hematopoietic stem cell transplantation with no guidance on management in the published literature. Medical therapy may be considered selected patients prior to surgical solutions.
Breast cancer rarely metastasizes to the muscles, and it is even more unusual for this phenomenon result in airway compromise. We present a unique case of an 84-year-old female who presented with neck swelling upper obstruction due metastatic breast invading sternocleidomastoid muscles. After establishing diagnosis discussing possible treatment options, patient elected antiestrogen therapy, palliative tracheostomy, radiation hospice services.
Multiple lymphomatous polyposis (MLP) as an extranodal manifestation of mantle cell lymphoma (MCL) in the gastrointestinal tract is rare and not often reported literature. We describe case a 63-year-old female with asymptomatic MLP found during staging bidirectional endoscopy MCL. The patient presented only dyspnea, but was on physical exam to have diffuse lymphadenopathy, subsequent positron emission tomography (PET) CT showed extensive lymph node adenopathy consistent lymphoma. Excisional...
TPS784 Background: Interleukin 1 alpha (IL-1a) is a pro-inflammatory cytokine that initiates and propagates sterile inflammatory responses. IL-1a present on the surface of tumors, released from necrotic cells within microenvironment, where it upregulates MMPs, VEGF, chemotactic cytokines, IL-6 contributing to tumor growth infiltration microenvironment by T-regulatory associated macrophages. also found platelets activates vascular endothelium allowing for circulating establish new areas...