A5062117565- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Virus-based gene therapy research
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Animal Virus Infections Studies
- Pain Mechanisms and Treatments
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Healthcare and Venom Research
- Histone Deacetylase Inhibitors Research
- Anesthesia and Pain Management
- Pediatric Pain Management Techniques
- Intraocular Surgery and Lenses
- Liver Diseases and Immunity
- Pancreatitis Pathology and Treatment
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Exercise and Physiological Responses
National Taiwan University
2016-2024
National Taiwan University Hospital
2019-2022
China Medical University
2011-2012
In Brief BACKGROUND: The underlying mechanism of exercise on neuropathic pain is not well understood. We investigated whether physical regulates the functional recovery and heat shock protein 72 (Hsp72), tumor necrosis factor-α (TNF-α), interlukin-1β (IL-1β) expression after chronic constriction injury (CCI) sciatic nerve. METHODS: Male Sprague–Dawley rats were divided into 7 groups: control, sham operated (SO), SO with swimming or treadmill (SOSE SOTE), CCI, CCI (CCISE CCITE). recorded body...
Abstract Hepatitis delta virus (HDV) is a satellite that requires hepadnavirus envelope proteins for its transmission. Although recent studies identified HDV-related deltaviruses in certain animals, the evolution of deltaviruses, such as origin HDV and mechanism coevolution with helper viruses, unknown, mainly because phylogenetic gaps among deltaviruses. Here, we novel passerine birds, woodchucks, white-tailed deer by extensive database searches molecular surveillance. Phylogenetic...
Overexpression of metastatic tumor antigen 1 (MTA1) was correlated with poor prognosis hepatitis B virus (HBV)-associated hepatocellular carcinoma (HBV-HCC). The aim this study to examine the clinical significance expression MTA1 and its exon 4-excluded form (MTA1dE4), most abundant spliced variant MTA1, in patients receiving curative resection for HBV-HCC. We collected 102 HBV-HCC received retrospectively examined expressions level total MTA1/MTA1dE4 their paired nontumor liver tissues by...
Background and Aims: Both nuclear cytoplasmic overexpression of metastatic tumor antigen 1 (MTA1) contributes to tumorigenesis HCC. Most studies have focused on MTA1 whose function is mainly a chromatin modifier regulating the expression various cancer‐promoting genes. By contrast, molecular mechanisms in carcinogenesis remain elusive. Here, we reveal role posttranscriptional gene regulation. Approach Results: We conducted vitro vivo RNA‐protein interaction assays indicating that could bind...
The metastatic tumor antigen 1 (MTA1) protein is associated with invasiveness and poor prognosis in patients hepatocellular carcinoma (HCC), particularly those hepatitis B virus (HBV)-related HCC. Chronically woodchuck (WHV)-infected an ideal animal model for studying the pathogenesis of HBV-associated liver diseases, including To investigate roles MTA1 hepatocarcinogenesis model, we cloned (wk-MTA1) complementary (c)DNA characterized its molecular functions. sequence organization wk-MTA1...
There are numerous established techniques for isolating hepatic myeloid cells; however, preserving their phenotypic and functional characteristics can be challenging. We present a straightforward efficient method to isolate cells, including Kupffer cells lymphocyte antigen 6 complex, locus C
Abstract Hepatitis delta virus (HDV) is a satellite that requires hepadnavirus envelope proteins for its transmission. Although recent studies identified HDV-related deltaviruses in certain animals, the evolution of deltaviruses, such as origin HDV and mechanism coevolution with helper viruses, unknown, mainly because phylogenetic gaps among deltaviruses. Here we novel passerine birds, woodchucks, white-tailed deer by extensive database searches molecular surveillance. Phylogenetic...