A5028824100- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Peripheral Nerve Disorders
- Elbow and Forearm Trauma Treatment
- Bone fractures and treatments
- Nerve Injury and Rehabilitation
- Trauma Management and Diagnosis
- Muscle and Compartmental Disorders
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Dupuytren's Contracture and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genital Health and Disease
- Health Literacy and Information Accessibility
- Medical Malpractice and Liability Issues
- RNA modifications and cancer
- Musculoskeletal pain and rehabilitation
- Nail Diseases and Treatments
- Social Media in Health Education
- Chemotherapy-related skin toxicity
- Diversity and Career in Medicine
- Anesthesia and Pain Management
- Interpreting and Communication in Healthcare
Brigham and Women's Hospital
2015-2025
Harvard University
2016-2025
Mass General Brigham
2016-2024
Boston Children's Hospital
2024
Massachusetts General Hospital
2014-2024
Boston University
2024
Peking University
2013-2023
Peking University People's Hospital
2013-2023
Collins College
2023
Lemuel Shattuck Hospital
2022
Despite advances in DNA methylome analyses of cells and tissues, current techniques for genome-scale profiling methylation circulating cell-free (ccfDNA) remain limited. Here we describe a methylated CpG tandems amplification sequencing (MCTA-Seq) method that can detect thousands hypermethylated islands simultaneously ccfDNA. This highly sensitive technique work with genomic as little 7.5 pg, which is equivalent to 2.5 copies the haploid genome. We have analyzed cohort tissue plasma samples...
The adipose Nod-like receptor protein 3 (NLRP3) inflammasome senses danger-associated molecular patterns (DAMPs) and initiates insulin resistance, but the mechanisms of activation remains elusive. In this study, Homocysteine (Hcy) is revealed to be a DAMP that activates adipocyte NLRP3 inflammasomes, participating in resistance. Hcy-induced inflammasomes were observed both adipocytes tissue macrophages (ATMs) mediated Lysophosphatidylcholine (lyso-PC) acted as second signal activator,...
The objectives of this study were to quantify adoption social media for the dissemination original research in orthopaedic and determine correlation between academic citations medial posts among recent publications.An Internet-based was performed 835 articles from three journals 2018 2019. number each article determined using Google Scholar Web Science. Twitter. calculated Spearman rank coefficient.The average per 4.6 on 2.6 3.6, which consisted 1.1 tweets 2.5 retweets. weakly correlated...
PurposePrior literature on the diagnostic accuracy of commonly used provocative tests for suspected carpal tunnel syndrome (CTS) is affected by research biases. The objectives our study were to measure and compare 4 CTS using electrodiagnostic as reference standard.MethodsWe prospectively evaluated 85 hands in 55 patients with CTS. Tinel sign, Phalen's test, Durkan's Phdurkan test (a combination wrist flexion compression) subsequent testing performed all patients. Sensitivity specificity...
Background: The purpose of this study was to determine the rates and types complications secondary surgeries after mini-open carpal tunnel release. Methods: A retrospective cohort performed for 1,328 patients who underwent release from August 2008 July 2013. Patients were excluded acute trauma, index procedure being revision surgery, neoplasm, age less than 18 years, incomplete records, postoperative follow-up 1 month, which yielded 904 1,144 surgeries. Results: Of releases performed, 14...
Xanthine oxidase (XOD) inhibition has long been considered an effective anti-hyperuricemia strategy. To identify natural XOD inhibitors with little side effects, we performed a inhibitory assay-coupled isolation of compounds from Smilacis Glabrae Rhizoma (SGR), traditional Chinese medicine frequently prescribed as agent for centuries. Through the in vitro assay, obtained novel inhibitor, 5-O-caffeoylshikimic acid (#1, 5OCSA) IC50 13.96 μM, well two known inhibitors, quercetin (#3) and...
Long-established patient-reported outcome measures (PROMs), such as the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) and QuickDASH, have been used traditionally to measure baseline symptoms treatment effects before after carpal tunnel release (CTR), but more recently, Patient-Reported Outcomes Measurement Information System (PROMIS) has increasingly in CTR patient population. We aimed correlation between legacy PROMIS PROMs for pain function a cohort of patients undergoing idiopathic...
PurposeTenosynovial biopsy at the time of carpal tunnel release affords a unique opportunity for early diagnosis amyloidosis. We aimed to build risk score stratify patients likely have undiagnosed amyloidosis.MethodsWe conducted prospective cohort study 320 adult with syndrome undergoing release. Patients underwent tenosynovial surgery. The primary outcome measure was positive amyloid deposition as assessed by Congo red and sulfated Alcian blue staining. generated assigning points each...
Background: This objective of this study was to identify risk factors for complications and reoperations after distal interphalangeal joint arthrodesis. Methods: A retrospective performed all patients who underwent isolated arthrodesis between 2006 2019 at an integrated health system consisting 2 Level I trauma centers community teaching hospitals. Demographics, implant, treatment characteristics were collected from the medical record. The primary outcome complication, secondary reoperation....