A5047552506- Sarcoma Diagnosis and Treatment
- Gut microbiota and health
- Renal and related cancers
- Protein Degradation and Inhibitors
- Colorectal Cancer Screening and Detection
- RNA and protein synthesis mechanisms
- Hippo pathway signaling and YAP/TAZ
- Genomics and Phylogenetic Studies
- Genomics and Chromatin Dynamics
- Molecular Biology Techniques and Applications
- Cancer-related gene regulation
- Xenotransplantation and immune response
- Cancer Genomics and Diagnostics
- Nutritional Studies and Diet
- Congenital heart defects research
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Enhanced Recovery After Surgery
- Histone Deacetylase Inhibitors Research
- Melanoma and MAPK Pathways
- Diet and metabolism studies
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Probiotics and Fermented Foods
University Hospital Heidelberg
2024-2025
Heidelberg University
2015-2025
University of Cape Town
2019-2025
The Eukaryotic Linear Motif (ELM) resource (http://elm.eu.org) is a manually curated database of short linear motifs (SLiMs). In this update, we present the latest additions to resource, along with more improvements web interface. ELM 2016 contains than 240 different motif classes over 2700 experimentally validated instances, from 2400 scientific publications. addition, data have been made available as individually searchable pages and are downloadable in various formats.
Abstract Background: The gut microbiome may be linked to colorectal cancer (CRC) prognosis. Few studies characterized the longitudinally across CRC treatment. Herein, we investigated dynamics before and up two years after surgery among newly diagnosed patients. Methods: We extracted DNA from stool collected at baseline (pre-surgery) 6, 12, 24-months in ColoCare Study. fecal bacteria using 16S rRNA gene sequencing (16S; N=133; 6 months only) whole-genome shotgun (WGS; N=41; all timepoints)....
Abstract Introduction: Diet plays a crucial role in shaping the gut microbiome, which turn can influence cancer progression and patient outcomes. Specific dietary patterns - such as those rich fiber, protein, healthy fats promote balanced support immune function, reduce inflammation, improve treatment response. In contrast, diets high processed foods unhealthy may disrupt potentially leading to poorer Understanding impact of on microbiome could provide valuable insights into personalized...
Sarcomas are highly aggressive cancers of mesenchymal origin whose clinical management is complex. This partly due to a lack understanding the molecular mechanisms underpinning transformation stromal/stem cells (MSCs) which presumed be sarcoma-initiating cells. c-Myc amplified/overexpressed in range sarcomas where it has an established oncogenic role and there evidence that contributes malignant MSCs. T-box transcription factor 3 (TBX3) upregulated by host sarcoma subtypes promotes...
Rhabdomyosarcoma is a highly aggressive malignant cancer that arises from skeletal muscle progenitor cells and the third most common solid tumour in children. Despite significant advances, rhabdomyosarcoma still presents therapeutic challenge, while targeted therapy has shown promise, there are limited options because molecular drivers of poorly understood. We previously reported T-box transcription factor 3 (TBX3), which been identified as druggable target many cancers, overexpressed...