A5017159299- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Erythropoietin and Anemia Treatment
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Eosinophilic Disorders and Syndromes
- Kruppel-like factors research
- Blood groups and transfusion
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Iron Metabolism and Disorders
- Hematological disorders and diagnostics
- Blood transfusion and management
- Pharmacological Effects and Toxicity Studies
- Hematopoietic Stem Cell Transplantation
- Blood disorders and treatments
- Cytokine Signaling Pathways and Interactions
- Blood properties and coagulation
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Neonatal Health and Biochemistry
- Clinical Laboratory Practices and Quality Control
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
2016-2025
University of Baltimore
1984-2024
Johns Hopkins Hospital
1972-2022
Case Western Reserve University
2013
University Hospitals Seidman Cancer Center
2013
American Society of Clinical Oncology
2010
Duke University
2010
Medical College of Wisconsin
2010
University of Bern
2010
Patients with solid tumors are often anemic even before they undergo cytotoxic therapy. Since the cause of anemia cancer is unknown, we examined possible role erythropoietin. Using a sensitive radioimmunoassay, determined serum immunoreactive erythropoietin levels in 81 patients tumors. For any given degree anemia, concentration was lower this group than control iron-deficiency (P = 0.0001). Furthermore, expected inverse linear relation between and hemoglobin absent cancer. The response...
The clinical and laboratory features of 23 new patients as well 50 previously reported with the syndrome hematophagic histiocytosis are reviewed. occurs more often in men than women but has no age predilection. Common presenting include fever, hepatic splenic enlargement, lymphadenopathy, profound depression blood counts. course is generally fulminant may be complicated by coagulation abnormalities, dysfunction renal failure. In majority patients, however, self-limited resolution...
The cause of polycythemia vera, which originates from a multipotent hematopoietic progenitor cell, is unknown. Thrombopoietin growth factor that regulates the production cells and platelets. To evaluate possibility an abnormality in thrombopoietin-mediated signal transduction might be involved pathogenesis we examined thrombopoietin-induced tyrosine phosphorylation proteins expression thrombopoietin receptor platelets patients with disease.
Serum immunoreactive erythropoietin (SIE) and hemoglobin levels were measured in 152 patients infected with the human immunodeficiency virus. Anemia was present 18% of asymptomatic who tested positive for virus, 50% a condition related to acquired syndrome (AIDS), 75% AIDS. The mean SIE level untreated AIDS (26.2 +/- 2.4 mU/mL) greater than virus or an AIDS-related but not outside normal range (4 26 mU/mL), incremental increase given decline much less uncomplicated iron deficiency anemia....
Erythropoietin mediates the rapid phosphorylation of Raf-1 in murine cell lines HCD-57 and FDC-P1/ER, which proliferate response to this cytokine. Phosphorylation occurs at both serine tyrosine residues as such is similar seen after interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, interleukin-2 stimulation other lines. Such data suggest that these growth factors may share a common mechanism(s) phosphorylation. Furthermore, association with phosphorylation,...
The prevalence of anemia in elective surgical patients may be as frequent 75% certain populations. A national audit demonstrated that 35% scheduled for joint replacement therapy have a hemoglobin <13 g/dL on preadmission testing. Standard practice currently consists testing 3 to 7 days before an operative procedure, precluding the opportunity effectively evaluate and manage patient with unexpected anemia. Therefore, standardized approach detection, evaluation, management preoperative setting...
In vitro incubation of leukemic bone marrow with the lipophilic fluorescent dye merocyanine 540 and simultaneous exposure to light reduced concentration L1210 leukemia cells by about 5 orders magnitude but spared enough normal pluripotent hematopoietic stem allow reconstitution lethally irradiated syngeneic mice. This simple rapid procedure may find an application in purging tumor from autologous grafts.
Abstract Serum immunoreactive erythropoietin (EP) levels were measured in 116 patients with rheumatoid arthritis (RA) and 20 control iron deficiency anemia. EP significantly higher the 46 anemic RA than 70 nonanemic (mean ± 1 SD 31.0 19.8 mU/ml versus 16.8 12.4 mU/ml; P < 0.0001). Furthermore, although a significant inverse correlation between serum level hemoglobin value was present (r = −0.57, 0.0001), regression coefficient describing relationship lower for anemia (F 6.01, 0.025).
The chronic myeloproliferative disorders (MPD) are clonal hematopoietic stem cell of unknown etiology. We have reported defective thrombopoietin receptor (Mpl) protein expression in MPD patients. To determine whether the basis abnormal Mpl was due to mutations gene, we sequenced cDNA from found a single nucleotide substitution (G1238T) that results change lysine asparagine at amino acid 39 (K39N) three African-American women referred for an evaluation MPD. subsequently screened more than 400...