A5010063415- Bone health and treatments
- Bone health and osteoporosis research
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Bone Metabolism and Diseases
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Neuroblastoma Research and Treatments
- Estrogen and related hormone effects
- Complement system in diseases
- Breast Cancer Treatment Studies
- Alcohol Consumption and Health Effects
- Eosinophilic Disorders and Syndromes
- Substance Abuse Treatment and Outcomes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Neuroendocrine Tumor Research Advances
- Heme Oxygenase-1 and Carbon Monoxide
- Sarcoidosis and Beryllium Toxicity Research
- Tuberous Sclerosis Complex Research
- Organ Donation and Transplantation
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
Aichi Medical University
2023-2024
Nagoya University Hospital
2019-2023
Nagoya University
2019-2023
Yokkaichi Municipal Hospital
2015-2020
BACKGROUND:In the field of living donor liver transplantation (LDLT), it is important to ensure donor's psychological well-being. We report on clinical features and long-term outcomes LDLT donors who developed psychiatric disorders after their operations. Additionally, we compare patient backgrounds, as well surgical perioperative aspects between with without postoperative complications. MATERIAL AND METHODS:Between November 1998 March 2018, identified 254 at our hospital. Among these,...
Neoadjuvant chemotherapy (NAC) using the combination of anthracycline and taxanes is standard regimen for patients with primary breast cancer. Among taxanes, conventional paclitaxel (PTX) docetaxel have usually been adopted in neoadjuvant or adjuvant setting. Nanoparticle albumin-bound (nab-PTX) a solvent-free formulation that can be delivered to cancer cells at higher doses than PTX. This study retrospective observational single institution. We evaluated efficacy safety nab-PTX followed by...
Background:The management and fate of liver transplant (LT) recipients with preformed donor-specific antibodies (pDSA) remain controversial.The aim this study was to evaluate the clinical impact rituximab desensitization on pDSA in LT recipients. Material/Methods:This retrospective observational enrolled 120 patients aged ³18 years.Patients were administered 500 mg/body 1-21 days before LT, except for those who had an active infection or insufficient time receive rituximab.We allocated...
In ABO blood group incompatible kidney transplantation (ABO-I), potential issues on acute antibody-mediated rejection (ABMR) remain to be solved. This study aimed assess the risk factors of ABMR using recipient- or donor-derived specimens. Quantitative analysis A/B antigen expression was conducted in 104 donor tissues (Kt), platelets (Plt), and red cells (RBC) by immunohistochemical staining flow cytometry (FCM). ABO-I pre-transplant recipient serum samples (ABMR = 12, non-ABMR 27) were...
Abstract Background There are long-standing controversies about the transplant indications for alcoholic liver disease (ALD), because of recognition that ALD is fundamentally self-inflicted. However, it unclear whether psychosocial characteristics different from non-alcoholic (NALD) in selection transplantation (LT) recipients. We aimed to clarify recipients (ALD-R)/ALD recipient candidates (ALD-RC) and NALD (NALD-R)/ (NALD-RC). Methods From 2011 2019, 75 patients were enrolled this...
Chronic high Epstein-Barr virus loads (CHEBV) are commonly observed in pediatric liver transplant patients. However, it is unclear how CHEBV impacts the graft. The aim of this study was to clarify clinical and pathological on graft.From 2012 2020, we retrospectively investigated 46 patients (under 16 years) who survived ≥6 months. were divided into two groups: group (EBV DNA >10 000 IU/ml whole blood for months) nonchronic EBV (NCHEBV) (patients did not meet criteria). Tacrolimus reduced...
Erythropoietic protoporphyria is a rare inherited metabolic disorder involving the heme biosynthesis pathway and leads to accumulation of protoporphyrin in erythrocytes or liver. Although peripheral neuropathy known develop occasionally other types porphyria, it rarely occurs patients with erythropoietic protoporphyria. A 16-year-old boy was transferred our hospital due end-stage liver disease secondary Severe systemic neuropathy, similar that presented Guillain-Barré syndrome, developed;...
Anatomic variations of the biliary tree are common, making precise anatomic evaluation important before hepatobiliary surgery. A 52-year-old woman with no medical history was admitted to our hospital for a live-liver donation her husband. During evaluation, magnetic resonance cholangiopancreatography (MRCP) revealed previously unknown variation in system. Segment 2 bile duct (B2) independently drained into posterior branch and formed common channel (B2+posterior) joining anterior branch....
症例は55歳，女性．左A領域に約8cm大の腫瘤と同側の腋窩，鎖骨上リンパ節の腫大を認め，画像診断は転移を疑った．原発巣の生検結果はcomedo type DCIS，リンパ節の細胞診検査は転移陰性であった．リンパ節の組織所見と画像所見の整合性が乏しいと思われたが，乳房全摘術とセンチネルリンパ節生検を行った．腫大したセンチネルリンパ節の迅速病理診断は転移を認めず，非乾酪性類上皮細胞肉芽腫病変を認めた．術後に行ったリンパ節の抗酸菌染色は陰性，胸部X線写真，Gaシンチグラフィーや血清ACE値は正常で，乳癌に伴ったsarcoid-like reactionと診断した．Sarcoid-like reactionは悪性腫瘍に合併するとの報告があるが頻度は少なく，病期診断の誤りから過剰治療をもたらす可能性があると思われる．
Recently, magnetic resonance imaging (MRI) has been developed as a widely available and noninvasive method for detecting evaluating hepatic iron overload. This case report presents successful living donor liver transplantation (LDLT) in which the was suspected to have deposition by MRI evaluation. A preoperative biopsy genetic examination were performed exclude hereditary hemochromatosis other chronic diseases. showed an almost normal specimen with slight of 2-3% hepatocytes, revealed no...
Neuroblastoma is the most common extracranial solid tumor in childhood. Stage 4S neuroblastoma a unique subset of characterized by favorable course and potentially low malignancy with high rate spontaneous regression. However, recent reports have shown that there subgroup patients stage MYCN amplification, chromosomal aberrations, age < 2 months at diagnosis, significantly poorer outcomes.A 1-month-old male infant huge abdominal was transferred to our hospital diagnosed neuroblastoma. The...
Introduction: Research on natural antibodies against carbohydrate antigens (alphaGal, NeuGc and Sda), complement, coagulation, inflammation cell mediated immunity (including innate immunity) has promoted production of suitable genetically modified pigs development effective monoclonal that block T cell-B (antigen presenting cell) communication through CD40-154 pathway. Recent advances in genome editing technology improved outcomes pig to NHP xenotransplantation model. Currently, clinical...
症例は69歳の女性で，上腹部痛を主訴に来院，上腹部に新生児頭大の腫瘤を触知し精査となった．血液生化学検査では，CA125の軽度上昇のみであった．腹部造影CTでは，肝左葉外側区域から突出し部分的に強く造影される長径15cm腫瘍を認めた．肝血管腫と診断し待機的手術を予定していたが，突然の腹部膨満感で救急外来を受診した．腹部造影CTで腫瘍の著明な増大と腹水の出現を認め，腫瘍破裂の診断で緊急手術を行った．腹腔内には血性腹水を大量に認め，腫瘍被膜が複数箇所で裂け出血していた．肝部分切除術を施行，腫瘍径は30cm，摘出肝重量は3,900gであり，短期間で急速増大していた．病理組織診断は肝未分化肉腫であった．術後の化学療法は希望されなかった．術後6カ月目に下腹部痛が出現し，腹部造影CTで肝転移，腹発播種再発を認め，術後8カ月目に死亡した．肝未分化肉腫の成人例での発症は本邦でも極めて稀で，予後不良である．
Abstract Background/AimThere are long-standing controversies about the transplant indications for alcoholic liver disease (ALD), because of recognition that ALD is fundamentally self-inflicted. However, it unclear whether stigmatization based on psychosocial aspects warranted in selection transplantation (LT) recipients. We aimed to clarify characteristics recipients (ALD-R)/ALD recipient candidates (ALD-RC) and non-ALD (NALD-R)/non-ALD (NALD-RC).MethodsFrom 2011 2019, 75 patients were...