A5069374975- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Meta-analysis and systematic reviews
- Venous Thromboembolism Diagnosis and Management
- Alzheimer's disease research and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Traumatic Brain Injury and Neurovascular Disturbances
- MicroRNA in disease regulation
- Clinical practice guidelines implementation
- Cerebrovascular and Carotid Artery Diseases
- MRI in cancer diagnosis
- GDF15 and Related Biomarkers
- Stroke Rehabilitation and Recovery
- Immune cells in cancer
- Pediatric Urology and Nephrology Studies
- S100 Proteins and Annexins
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
The Royal Melbourne Hospital
2022-2024
The University of Melbourne
2022-2024
Walter and Eliza Hall Institute of Medical Research
2024
Patients with large vessel occlusion (LVO) stroke presenting milder baseline clinical severity are common and require endovascular thrombectomy. However, such patients difficult to recognize using pre-hospital severity-based triage tools therefore likely a secondary inter-hospital transfer if transported non-thrombectomy center. Given the potential for represent better underlying cerebrovascular collateral circulation, it is unknown whether delays still associated poorer post-stroke outcomes...
Minimal sufficient balance (MSB) is a recently suggested method for adaptively controlling covariate imbalance in randomized controlled trials manner which reduces the impact on randomness of allocation over other approaches by only intervening when sufficiently significant. Despite its improvements, approach unable to consider relative clinical importance or magnitude each weight, and ignores any not statistically significant, even these imbalances may collectively justify intervention. We...
A recent review of randomization methods used in large multicenter clinical trials within the National Institutes Health Stroke Trials Network identified preservation treatment allocation randomness, achievement desired group size balance between groups, baseline covariate balance, and ease implementation practice as critical properties required for optimal designs. Common-scale minimal sufficient (CS-MSB) adaptive effectively controls imbalance groups while preserving randomness but does...
Abstract Background and Purpose Patients with large vessel occlusion (LVO) stroke of milder baseline clinical severity are often missed by pre-hospital severity-based triage tools. We examined whether these patients had differences in 1) markers collateral circulation 2) the relative harm transfer delays on outcome, compared to clinically more severe deficits. Methods Registry data from two Australian thrombectomy centers was used identify all directly presenting transferred LVO undergoing...
Renal diffusion tensor imaging (DTI) is a promising, non-invasive biomarker for kidney function. Cortical and medullary fractional anisotropy (FA) mean diffusivity (MD) correlates with early microstructural functional changes in diseases. However, reliability of DTI metrics affected by artifacts. The ideal renal sequence robust reproducible measurements remains under investigation. We report on prototype small field-of-view (FOV) incorporating 2D selective rotated RF excitation automatic...