A5001539034- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Alzheimer's disease research and treatments
- Biosimilars and Bioanalytical Methods
- Multiple Sclerosis Research Studies
- Atrial Fibrillation Management and Outcomes
- Geriatric Care and Nursing Homes
- Amyotrophic Lateral Sclerosis Research
- Pharmaceutical studies and practices
- Pharmaceutical Economics and Policy
- Blood Pressure and Hypertension Studies
- COVID-19 and Mental Health
- Cultural, Media, and Literary Studies
- Cardiovascular Function and Risk Factors
- Pharmaceutical Practices and Patient Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Nosocomial Infections in ICU
- Economic and Financial Impacts of Cancer
- Erythropoietin and Anemia Treatment
- Acute Lymphoblastic Leukemia research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Pharmacovigilance and Adverse Drug Reactions
- Genetics, Bioinformatics, and Biomedical Research
National Centre for Disease Prevention and Control
2018-2024
Istituto Superiore di Sanità
2017-2024
Agenzia Regionale Parchi
2013-2017
Regione Campania
2014
Regione Lazio
2013-2014
Oxford BioMedica (United Kingdom)
2011
University of Oxford
2011
Ludwig-Maximilians-Universität München
2011
Centre Georges François Leclerc
2010
Universidad Autónoma de Madrid
1991
<b><i>Background:</i></b> Up to 53.7% of all cases dementia are assumed be due Alzheimer disease (AD), while 15.8% considered vascular (VaD). In Europe, about 3 million AD could 7 potentially modifiable risk factors: diabetes, midlife hypertension and/or obesity, physical inactivity, depression, smoking, and low educational level. <b><i>Aims:</i></b> To estimate the number VaD in Europe Italy attributable these factors....
To assess the diagnostic accuracy of free and cued selective reminding test (FCSRT) for development Alzheimer's disease (AD) in people with mild cognitive impairment (MCI). We enrolled 187 consecutive MCI outpatients from a memory clinic that were evaluated at baseline every 6 to 12 months through an extensive clinical neuropsychological protocol. For each test, measures obtained. improve overall specificity battery, we also used tests parallel combination. The association between FCSRT...
Compared with other areas of the country, very limited data are available on multiple sclerosis (MS) prevalence in Central Italy. We aimed to estimate MS Lazio region and its geographical distribution using regional health information systems (HIS). To identify cases we used from drug prescription, hospital discharge ticket exemption registries. Crude, age- gender-specific estimates December 31, 2011 were calculated. compare between different within region, calculated gender-adjusted ratios...
Older people living in nursing homes (NHs) are particularly vulnerable the ongoing COVID-19 pandemic, due to high prevalence of chronic diseases and disabilities (e.g., dementia). The phenomenon adverse events (AEs), intended as any harm or injury resulting from medical care failure provide care, has not yet been investigated NHs during pandemic. We performed a national survey on 3,292 NHs, either public providing services both privately within health system, out 3,417 covering whole Italian...
Abstract Background Although sex differences in cardiovascular diseases are recognised, including incidence, clinical presentation, response to treatments, and outcomes, most of the practice guidelines not sex-specific. Heart failure (HF) is a major public health challenge, with high care expenditures, prevalence, poor outcomes. The objective was analyse sex-specific association socio-demographics, life-style factors characteristics prevalence HF diastolic left ventricular dysfunction (DLVD)...
Fibroblast growth factor-23 (FGF-23) and vitamin D are hormones involved in phosphate homoeostasis. They also directly influence cardiomyocyte hypertrophy. We examined whether the relationships between levels of or FGF-23, cardiac phenotype outcome were independent established biomarkers a large cohort community-dwelling elderly subjects.Plasma FGF-23 measured 1851 men women (65-84 years) resident Lazio region Italy. Participants referred to eight cardiology centres for clinical examination,...
Residents in facilities such as nursing homes (NHs) are particularly vulnerable to Coronavirus disease 2019 (COVID-19). A national survey was carried out collect information on the spreading and impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection homes, how suspected and/or confirmed cases were managed. We a between 25 March 2020 5 May 2020.All Italian either public or providing services both privately within NHS included study. An on-line questionnaire sent 3292...
Pneumonia has traditionally been classified into two subtypes: community-acquired pneumonia (CAP) and nosocomial (NP). Recently, a new entity defined, called healthcare-associated (HCAP). Few studies have investigated the potential of population-based, electronic, healthcare databases to identify incidences these three subtypes pneumonia. The aim this study was estimate burden in elderly patients (aged 65+ years) large region central Italy.A retrospective cohort performed using linked...
To evaluate the benefit/risk profile of epoetin α biosimilar with erythropoiesis-stimulating agents (ESAs) originators when administered to naïve patients from clinical practice.
Background: Italy has one of the oldest populations in World and more than million dementia cases can be estimated at national level. Objective: The objectives this survey include: 1) to report administrative features professional competencies Centers for Cognitive Disorders Dementias (CCDDs); 2) document possible discrepancies by geographic macro-area; 3) identify CCDDs that are associated with a better quality provision care. Methods: A Italian was conducted between February 2014 December...
Current guidelines recommend prophylaxis with granulocyte colony-stimulating factors (G-CSFs) for patients cancer who are at greater risk of febrile neutropenia (FN) while receiving chemotherapy. G-CSF biosimilars available and represent a savings opportunity; however, their uptake has thus far been low. Our objective was to evaluate prescribing patterns G-CSFs in the prevention chemotherapy-related FN impact regional guidance on prescription. We conducted an observational drug-utilization...
To investigate whether the prices of new anticancer drugs correlated with their relative benefit despite negotiation.Retrospective cross-sectional study correlating clinical outcomes.We did a retrospective including all approved by European Medicines Agency (EMA) (2010-2016) and reimbursed in Italy.Information on outcomes-in terms median overall survival (OS), progression-free (PFS) objective response rate (ORR)-was extracted from pivotal trials as reported Public Assessment Reports...
Abstract Background As of 2024, vaccination remains the main mitigation measure against COVID-19, but there are contradictory results on whether people living with HIV (PLWH) less protected by vaccines than without (PLWoH). In this study we compared risk SARS-CoV-2 infection and COVID-19 hospitalisation following full in PLWH PLWoH. Methods We linked data from registry, surveillance system healthcare/pharmacological registries four Italian regions. identified fully vaccinated (14 days post...
In recent years, significant efforts have been directed towards the research and development of disease-modifying therapies for dementia. These drugs focus on prodromal (mild cognitive impairment, MCI) and/or early stages Alzheimer's disease (AD). Literature evidence indicates that a considerable proportion individuals with MCI do not progress to Identifying at higher risk developing dementia is essential appropriate management, including prescription new expected become available in...
Cases of appendicitis were identified in the pivotal randomized clinical trial on BNT162b2 mRNA vaccine and reported from coronavirus disease 2019 (COVID-19) pharmacovigilance systems. Three cohort studies two self-controlled case series (SCCS) evaluating association between vaccines discordant results. To address this uncertainty, present study examines a large population, with SCCS design, (BNT162b2 mRNA-1273) and, for first time, viral vector (ChAdOx1-S Ad26.COV2-S) COVID-19 acute appendicitis.
Background Real‐time monitoring is used to the ends of postmarketing observational research on newly marketed drugs. We implemented a pilot near‐real‐time program test case oral anticoagulants. Specifically, we evaluated safety and effectiveness direct anticoagulants compared vitamin K antagonists in nonvalvular atrial fibrillation secondary prevention during 2013‐2015 Lazio Region, Italy. Methods Results A cohort study was conducted using sequential propensity‐score–matched new user...
Abstract Background Amyotrophic lateral sclerosis (ALS) is a highly debilitating neurodegenerative condition. Despite recent advancements in understanding the molecular mechanisms underlying ALS, there have been no significant improvements therapeutic options for ALS patients years. Currently, cure and only approved treatment Europe riluzole, which has shown to slow disease progression prolong survival by approximately 3 months. Recently, tauroursodeoxycholic acid (TUDCA) emerged as...
Mild cognitive impairment (MCI) is a nosological entity proposed by Petersen in 1999 with the objective of identifying an early stage dementia. The new diagnostic criteria for dementia, both those promoted International Working Group (IWG) and defined National Institute Aging (NIA), subsequently introduced model that starts preclinical phase, then proceeds prodromal ends phase condition known as subjective disorder (SCD) included between preclinic phases. Most clinicians improperly consider...
<b><i>Background:</i></b> It is common that the epidemiology of multiple sclerosis (MS) varies with geography and ethnicity. Recent studies show a continuous growth incidence prevalence in Sicily, despite controversial “latitude gradient theory.” <b><i>Objectives:</i></b> The aim our study to ascertain rates MS city Biancavilla, Southern Italy. <b><i>Method:</i></b> Case ascertainment approach clinical database...