A5110409716- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- Lung Cancer Treatments and Mutations
- Hepatitis C virus research
- Substance Abuse Treatment and Outcomes
- Temporomandibular Joint Disorders
- Sphingolipid Metabolism and Signaling
- Organ Transplantation Techniques and Outcomes
- Neonatal Respiratory Health Research
- Drug Transport and Resistance Mechanisms
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Pleural and Pulmonary Diseases
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Mental Health Treatment and Access
- Acute Myeloid Leukemia Research
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
- ATP Synthase and ATPases Research
- SARS-CoV-2 and COVID-19 Research
- Nanoplatforms for cancer theranostics
Soochow University
2017-2023
First Affiliated Hospital of Soochow University
2017-2023
Nanjing University of Chinese Medicine
2023
Hebei University of Engineering
2022
Affiliated Hospital of Hebei University
2022
Hainan General Hospital
2017
Indiana University Bloomington
2017
Health Services Research & Development
2015
Center for Innovation
2015
VA Palo Alto Health Care System
2015
Abstract Background A synergistic effect of combination therapy with favipiravir and oseltamivir has been reported in preclinical models influenza. However, no data are available on the clinical effectiveness severe Methods Data from 2 separate prospective studies influenza adults were used to compare outcomes between monotherapy. Outcomes included rate improvement (defined as a decrease categories 7-category ordinal scale) viral RNA detectability over time. Subhazard ratios (sHRs) estimated...
BackgroundThe pharmacokinetics and appropriate dose regimens of favipiravir are unknown in hospitalized influenza patients; such data also needed to determine dosage selection for trials COVID-19.MethodsIn this dose-escalating study, tolerability were assessed critically ill patients. Participants received one two dosing regimens; Japan licensed (1600 mg BID on day 1 600 the following days) higher (1800 mg/800 BID) trialed uncomplicated influenza. The primary pharmacokinetic endpoint was...
Abstract Background We aimed to describe psittacosis pneumonia and risk factors for developing severe in this multicenter clinical study. Methods collected the data of cases diagnosed with metagenomic next-generation sequencing (mNGS) assay from April 2018 2022 15 tertiary hospitals China. Results A total 122 patients were enrolled; 50.0% had a definite history bird exposure. In 81.2% cases, onset happened autumn or winter. The common symptoms fever (99.2%), cough (63.1%), fatigue (52.5%),...
Immunotherapies targeting the programmed cell death 1 (PD-1)/programmed ligand (PD-L1) have shown great promise for a subset of patients with non-small lung cancer (NSCLC). However, safe and robust combination therapies are still needed to bring benefit broader patient populations. we performed in vivo treatment PD-L1 antibody Lewis carcinoma (LLC)-derived murine NSCLC model. Expression B T lymphocyte attenuator (BTLA) was detected during treatment. We evaluated effects anti-BTLA anti-PD-L1...
Spinster homolog 3 (SPNS3) belongs to the (SPNS) family which participates in sphingolipid transportation through cell membrane. However, functions of SPNS3 acute myeloid leukemia (AML) are unknown. This study obtained from a gene set that was related AML relapse and evaluate whether high expression induced apoptosis resistance an line, is consistent with role as marker poor prognosis clinic. Moreover, internal tandem duplication FMS-like tyrosine kinase (FLT3-ITD) mutation AC127521.1/...
Abstract Purpose CD8 + T cells in tumors are heterogenous and comprise multiple differentiation states. It has been reported that human tumor-infiltrating can express CD39 more evidences proposed as a marker of exhausted tumor reactive cells. However, no studies have delved into the spatial distribution cell subsets lung cancer, which could help to evaluate immune microenvironment for developing future immunotherapy approaches. Methods A total 53 cancer patients prior any therapy were...
The combined treatment of transcatheter arterial chemoembolization (TACE) and apatinib had beneficial effects on the survival patients with advanced hepatocellular carcinoma (HCC), but efficacy this regimen is still controversial needs further investigation.
Abstract Immune checkpoint blockade (ICB) has shown improvement in overall survival for lung cancer clinical trials. However, monotherapies have limited efficacy improving outcomes and benefit only a subset of patients. Combination therapies targeting multiple pathways can augment an immune response to improve further. Here, we demonstrate that combinatorial anti-PD-L1/cryoablation therapy generated synergistic antitumor activity the established model. Importantly, it was observed this...
Malignant pleural effusions (MPE) are common in lung cancer, which were a complex microenvironment containing plethora of immune and tumor signals. Gene alterations such as driver gene mutations considered to affect the components TIME NSCLC. Here, we demonstrated that CD39+CD8+T cells selectively elevated firstly-diagnosed adenocarcinoma with wild-type EGFR compared mutant EGFR, while abnormally more represented MPE epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)...
Abstract Malignant pleural effusion (MPE) is common in lung cancer, which was a complex microenvironment containing plethora of immune and tumor signals. Gene alterations such as driver gene mutations were considered to affect the components TIME non-small-cell cancer （NSCLC）. Here, we demonstrated that CD39+CD8+T cells selectively elevated firstly-diagnosed adenocarcinoma with wild-type epidermal growth factor receptor (EGFR wt ) compared mutant mu ), while abnormally more represented MPE...
Objective To investigate the portal vein embolization (PVE) and ligation (PVL) in liver regeneration of rats with hepatic fibrosis . Methods Fifty were prepared, including 10 randomly chosen as pre-operative control group. The other 40 divided into two groups: PVE group (A1, n=20) PVL (A2, n=20). We chose to embolize ligate right vein, respectively. blood samples obtained at different end points for measuring ALT AST levels. Each lobes whole weighed, non-embolized lobe/whole weight...
Department of Respiratory, The First Affiliated Hospital Soochow University, Suzhou, China *Address for correspondence: 188 Shizi St, Suzhou 215006, China. E-mail: [email protected] authors have no conflicts interest to declare.