A5031175646- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastrointestinal motility and disorders
- Probiotics and Fermented Foods
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Occupational and environmental lung diseases
- Occupational exposure and asthma
- Transgenic Plants and Applications
University of Michigan
2019-2022
Michigan United
2022
Dietary fiber provides a variety of microbiota-mediated benefits ranging from anti-inflammatory metabolites to pathogen colonization resistance. A healthy gut microbiota protects against Clostridioides difficile colonization. Manipulation these microbes through diet may increase resistance improve clinical outcomes. The primary objective this study was identify how the dietary xanthan gum affects and C. We added 5% C57BL/6 mice examined its effect on 16S rRNA gene amplicon sequencing...
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease characterized by collagen deposition within the lung interstitium. Bacterial infection associated with increased morbidity more rapid mortality in IPF patient populations, pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) are commonly isolated from lungs of hospitalized patients IPF. Despite this, effects fibrotic injury on critical immune responses to remain unknown. In present study, we show that,...
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible disease characterized by collagen deposition within the interstitium of lung. This impairs gas exchange and results in eventual respiratory failure. Clinical studies show correlation between elevated neutrophil numbers IPF progression; however, mechanistic roles neutrophils play this are not well described. In present study, we describe alterations to trafficking function after development fibrosis. We observed...
Abstract Dietary fiber provides a variety of microbiota-mediated benefits ranging from anti-inflammatory metabolites to pathogen colonization resistance. A healthy gut microbiota protects against Clostridioides difficile colonization. Manipulation these microbes through diet may increase resistance improve clinical outcomes. The primary objective this study was identify how the dietary xanthan gum affects and C. We added 5% C57Bl/6 mice examined its effect on 16S rRNA-gene amplicon...
Abstract The mammalian gut is home to a vibrant community of microbes. As the microbiota has evolved, its members have formed complex yet stable relationships that prevent non-indigenous microorganisms, such as Clostridioides difficile , from establishing within gut. Using bioreactor model gut, we characterize how variation in microbial assembly changes ability resist C. . We established diluted communities healthy human stool and subsequently challenged them with vegetative 16S rRNA-gene...