A5048243437- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Fluorine in Organic Chemistry
- Chemical Reactions and Mechanisms
- Advanced Polymer Synthesis and Characterization
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Monoclonal and Polyclonal Antibodies Research
- Biochemical Acid Research Studies
- Viral Infections and Immunology Research
- Organic and Inorganic Chemical Reactions
- Synthesis and Reactions of Organic Compounds
- Chemical Reaction Mechanisms
- HIV/AIDS Research and Interventions
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Reproductive tract infections research
- Cyclization and Aryne Chemistry
- Polymer crystallization and properties
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- Carbohydrate Chemistry and Synthesis
- Synthesis of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Antimicrobial Peptides and Activities
A.V. Topchiev Institute of Petrochemical Synthesis
1989-2019
Russian Academy of Sciences
1995-2011
N2 Biomedical (United States)
2010
State Research Center of the Russian Federation
2010
Oles Honchar Dnipro National University
2008
Biomod (Canada)
2008
Moscow State University of Fine Chemical Technologies
1981
In previous works we reported the design, synthesis and in vitro evaluations of synthetic anionic polymers modified by alicyclic pendant groups (hydrophobic anchors), as a novel class inhibitors human immunodeficiency virus type 1 (HIV-1) entry into cells. Recently, these interactions with key mediator HIV-1 entry-fusion, tri-helix core first heptad repeat regions [HR1]3 viral envelope protein gp41, were pre-studied via docking terms newly formulated algorithm for stepwise approximation from...
Abstract Self assembly of viral biopolymers to nano‐complexes forming virions during virus delivery from infected cell and reverse disintegration entry into new cells play a crucial role in life cycle diseases. Therefore artificial instruments for selective counter intervention these processes are dramatically required the high effective antiviral protection. Hybrid macromolecular systems (HMS) rationally integrating heterogeneous structure‐functional factors recognition ‐ inhibition viruses...
Abstract The alternating cyclocopolymer of maleic anhydride with divinyl ether (MADVE) hydrolyzate, as mimicker furan related and anionic residues alternation in nucleic acids (NA) backbone, is immune stimulating agonist competitive antagonist for viral genome NA interventions. targeted pre‐modification MADVE by antiviral vectors via grafting to the MA before hydrolysis led more potent promising inhibitors. To develop capacity novel modifications we applied reversible addition –...
Abstract Products of free‐radical polymerization (FRP) are usually not regulated on the molecular scale, consisting blocks obtained through fastest kinetic scheme pathways. The side or kinetically restricted products can be a source impurities in complex FRP case, possess new properties if isolated solely. synthesis poly(divinyl ether‐alt‐maleic anhydride), known as “DIVEMA”, serves example with such and thermodynamic complexities. Uncertainty factors regulating polymer structure is...