A5003991751- Parasites and Host Interactions
- Liver Disease Diagnosis and Treatment
- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasite Biology and Host Interactions
- Vitamin C and Antioxidants Research
- SARS-CoV-2 and COVID-19 Research
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Apelin-related biomedical research
- HIV Research and Treatment
- Child Nutrition and Water Access
- COVID-19 Clinical Research Studies
- Global Maternal and Child Health
- Helminth infection and control
- IL-33, ST2, and ILC Pathways
- Adrenal Hormones and Disorders
- Diet, Metabolism, and Disease
- Eosinophilic Esophagitis
- HIV/AIDS oral health manifestations
- Hepatitis Viruses Studies and Epidemiology
- Systemic Sclerosis and Related Diseases
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Outbreaks Research
- Wnt/β-catenin signaling in development and cancer
Université de Yaoundé I
2017-2025
University of Utah
2021-2025
Ministry of Scientific Research and Innovation
2021-2025
Catholic University of Central Africa
2015-2024
Université de Dschang
2023
University of Cape Town
2018-2022
South African Medical Research Council
2018-2022
International Centre for Genetic Engineering and Biotechnology
2018-2022
Wellcome Centre for Infectious Diseases Research in Africa
2022
Abstract Tissue fibrosis underlies the majority of human mortality to date with close half all reported deaths having a fibrotic etiology. The progression is very complex and reputed irreversible once established. Although some preventive options are being reported, therapeutic still scarce in high demand, given rise diseases linked fibroproliferative disorders. Our work explored four platforms, complementarily, order screen potentials antiparasitic drug Praziquantel as possible...
Schistosomiasis is a potentially lethal parasitic disease that profoundly impacts systemic immune function in chronically infected hosts through mechanisms remain unknown. Given the immunoregulatory dysregulation experienced individuals, this study examined impact of chronic schistosomiasis on sustainability vaccine-induced immunity both children living endemic areas and experimental infections mice. Data show Schistosoma mansoni infection impaired persistence vaccine specific antibody...
Background and Methods: Schistosomiasis is debilitating reported to impair immune responsiveness of infected hosts. In Cameroon, mass drug administration (MDA) used in schoolchildren reduce transmission S. haematobium mansoni. The effects MDA the impact schistosomiasis on titers antibodies vaccinated children have been poorly studied. We therefore assessed prevalence schoolchildren, eight months after MDA, two locations: Barombi Koto (BK), endemic for (N =169) Yoro (Y), mansoni = 356). Age,...
Malaria and typhoid fever pose significant health risks, leading to severe morbidity mortality when inadequately treated. Understanding the role of stress-related inflammatory cytokines is crucial, as they mediate immune responses that affect pathogen clearance recovery. This study investigated cytokine profiles in patients with malaria and/or attending Obala District Hospital Yaoundé, Cameroon. We conducted a cross-sectional observational measuring cortisol blood samples from 55 infected...
Background Currently available schistosomiasis diagnostic and monitoring tools are limited, the development of novel technologies is necessary to enhance disease surveillance by supporting elimination efforts. Novel disease-specific biomarkers can facilitate these technologies. Through comparison parasite burden host factors, we assessed whether plasma cytokines could be used as robust for intestinal associated pathology in school-aged children (SAC) living endemic areas. Methods Levels were...
Introduction SARS-CoV-2 and Mycobacterium tuberculosis (Mtb) share similarities in their modes of transmission, pathophysiological symptoms, clinical manifestations. An imbalance the immune response characterised by elevated levels some inflammatory cytokines caused (TB) COVID-19 may increase risk developing a severe disease-like condition. It has been reported that TB increases expression Ace2 (angiotensin converting enzyme 2) Tmprss2 (transmembrane protease serine proteins, which are...
Background: This study aimed to investigate the association of plasma levels IL-33, a mucosal alarmin known elicit type-2 immunity, with infection and liver fibrosis profiles school children from an endemic area for Schistosoma mansoni, malaria hepatitis (B & C) in rural Cameroon. Methods: A cross-sectional enrolling schoolchildren 5 public schools was conducted. Single schistosomiasis, infections or co-infections were assessed by kato katz, microscopy, rapid diagnostic tests, respectively....
Background: HCC incidence is increasing worldwide due to the obesity epidemic, which drives metabolic dysfunction-associated steatohepatitis (MASH) that can lead HCC. However, molecular pathways driving MASH-HCC are poorly understood. We have previously reported male mice with haploinsufficiency of hypoxia-associated factor, HAF ( SART1 +/- ) spontaneously develop MASH-HCC. cell type(s) responsible for associated loss unclear. Results: generated -floxed mice, were crossed expressing...
Erythropoietin-producing hepatocellular (Eph)/Ephrin cell-cell signaling is emerging as a key player in tissue fibrogenesis. The aim of this study was to test the hypothesis that receptor tyrosine kinase EphB2 mediates dermal fibrosis systemic sclerosis (SSc).
Study Objective and Hypothesis: The pathogenesis of fibrosis during metabolic dysfunction-associated steatohepatitis (MASH) is not fully understood. Our previous work indicate that the Eph/Ephrin signaling could be a major cell-cell hub regulating fibrogenesis in MASH. While interaction between HSC liver sinusoidal endothelial cells (LSEC) has long been proposed as driver for fibrosis, molecular mechanisms their have elaborated. In this study, we tested hypothesis EphrinB ligands expressed...
The alloimmunization of the ABO blood group system is involved in neonatal jaundice with a considerable overall prevalence. role incompatibility relatively little known. purpose this study was to investigate due feto-maternal incompatibilities and determine link between hemolysins value mother degree observed infant.We conducted cross-sectional from June November 2015. population exclusively composed moms who were type O children different hospitalized Department Neonatology at Reference...
Abstract The grading system for ultrasonographic assessment of Schistosoma mansoni morbidity is crucial evaluation control programs. This requires prior definition normal liver organometric ranges in the population from endemic area. A cross-sectional study was conducted a S. area rural Cameroon. 1002 Participants were screened and 234 them, free all common liver-affecting diseases (schistosomiasis, malaria, hepatitis B C) with no signs disease selected their parameters measured by...
Background & Aims: The receptor tyrosine kinase EphB2 is now emerging as a critical regulator of inflammation and fibrogenesis in metabolic dysfunction-associated steatohepatitis (MASH) though the underlying mechanism remain unclear. We aimed to investigate role or by which contributes progression MASH fibrogenesis. Hypothesis: hypothesized that hepatic stellate cells (HSCs) promotes MASH-liver fibrosis Methods: Single nuclear RNA-sequencing liver from human mouse were analyzed for...
Abstract Background Malaria and typhoid fever are known to cause severe morbidity mortality if miss-treated or left untreated. The oxidant/antioxidant immune responses these diseases involve a complex interplay of stress-mediating inflammatory cytokines which orchestrate coherent response that leads pathogen clearance recovery. This study investigated the stress-mediated cytokine profiles in patients attending Obala District Hospital, Yaoundé, Cameroon diagnosed with malaria and/or fever....
Malaria kills nearly 619,000 people each year. Despite the natural immunity acquired to malaria, pregnant women and children under five die from severe forms of disease in sub-Saharan Africa. Co-infection with acute Epstein-Barr Virus (EBV) infection has been shown suppress anti-malarial humoral responses, but little is known about impact EBV reactivation on malaria-associated morbidity. This study investigated association between malaria severity living a malaria-endemic region Cameroon. A...
Abstract SARS-CoV-2 and Mycobacterium tuberculosis ( Mtb ) share similarities in their modes of transmission, pathophysiological symptoms, manifestations. An imbalance the immune response characterized by significantly elevated levels some inflammatory cytokines may increase risk developing both (TB) COVID-19 as a comorbid condition. The role SNPs ace2 tmprss2 conferring higher susceptibility to TB-COVID-19 co-infection is relatively underexplored. In this study, Cameroonian cohort...
Abstract Objectives : Most malaria diagnostic methods are invasive whereas non-invasive alternatives like saliva could be used for molecular diagnosis. However, long-term storage of also requires a cold chain, which is challenging in poor countries. Current tools to conserve at room temperature not affordable (~$16/kit) endemic In this cross-sectional study including 83 febrile participants, we evaluated the effectiveness cheaper (~$2/kit) homemade kit (Formulation f1 ) stabilize Plasmodium...
Introduction: HIV-1 and Mtb are characterized by immune activation unbalances production of cytokines, but the expression IL33 in HIV/TB coinfection remain understudied. This study aimed to evaluate level IL-33 plasma HIV M.tuberculosis (HIV/TB) coinfected patients compared with respective mono infections Yaoundé.