A5020574039- Sleep and Wakefulness Research
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Optical Imaging and Spectroscopy Techniques
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant Stress Responses and Tolerance
- Non-Invasive Vital Sign Monitoring
- Circadian rhythm and melatonin
- Respiratory Support and Mechanisms
- Plant Micronutrient Interactions and Effects
- Plant Physiology and Cultivation Studies
- Plant Reproductive Biology
- Postharvest Quality and Shelf Life Management
- Cardiovascular and Diving-Related Complications
- Wastewater Treatment and Nitrogen Removal
- Neuroscience of respiration and sleep
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- HIV/AIDS drug development and treatment
- Heart Rate Variability and Autonomic Control
- Restless Legs Syndrome Research
- Plant Surface Properties and Treatments
- Cardiovascular and exercise physiology
- Horticultural and Viticultural Research
- Intensive Care Unit Cognitive Disorders
Gansu Agricultural University
2020-2025
Klinik Barmelweid
2016-2025
SleepMed
2015-2025
Beijing University of Technology
2021-2024
Chinese Academy for Environmental Planning
2024
Nanjing Agricultural University
2024
Hangzhou Medical College
2024
Robert Bosch (Germany)
2023-2024
Charles University
2022
Chongqing Three Gorges Central Hospital
2021-2022
With the evolution of network function virtualization (NFV), diverse services can be flexibly offered as service chains (SFCs) consisted different virtual functions (VNFs). However, state and traffic typically exhibit unpredictable variations due to stochastically arriving requests with quality (QoS) requirements. Thus, an adaptive online SFC deployment approach is needed handle real-time various requests. In this paper, we firstly introduce a Markov decision process (MDP) model capture...
Soil salinization severely restricts the growth and development of crops globally, especially in northwest Loess Plateau, where apples constitute a pillar industry. Nanomaterials, leveraging their unique properties, can facilitate transport nutrients to crops, thereby enhancing plant under stress conditions. To investigate effects nano zinc oxide (ZnO NP) on physiological characteristics apple self-rooted rootstock M9-T337 seedlings saline alkali stress, one-year-old were used as...
Abstract Background Heart rate, acidosis, consciousness, oxygenation, and respiratory rate (HACOR) have been used to predict noninvasive ventilation (NIV) failure. However, the HACOR score fails consider baseline data. Here, we aimed update take into account data test its predictive power for NIV failure primarily after 1–2 h of NIV. Methods A multicenter prospective observational study was performed in 18 hospitals China Turkey. Patients who received because hypoxemic were enrolled. In...
Abstract Background MaiLi-E is a lidocaine-containing cross-linked sodium hyaluronate gel for dermal filling. This prospective, multicenter, randomized, delayed-treatment controlled, evaluator-blinded clinical trial aims to evaluate the efficacy and safety of chin augmentation. Methods Participants with mild-to-moderate–severe retrusion were enrolled randomized (2:1) receive at study onset (MaiLi-E group) or six months later (control group). The primary endpoint was response rate...
Azaindole derivatives derived from the screening lead 1-(4-benzoylpiperazin-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione (1) were prepared and characterized to assess their potential as inhibitors of HIV-1 attachment. Systematic replacement each unfused carbon atoms in phenyl ring indole moiety by a nitrogen atom provided four different azaindole that displayed clear SAR for antiviral activity all which marked improvements pharmaceutical properties. Optimization these leads resulted...
Chronotype is the propensity for a person to sleep at particular time during 24 hours. It largely regulated by circadian clock but constrained work obligations specific schedule. The discrepancy between biological and social can be described as jetlag (SJL), which highly prevalent in modern society associated with health problems. SJL chronotypes have been widely studied Western countries never China.We characterized mainland China objectively analyzing database of Chinese sleep-wake pattern...
Purpose: Narcolepsy type-1 (NT1) is a rare chronic neurological sleep disorder with excessive daytime sleepiness (EDS) as usual first and cataplexy pathognomonic symptom. Shortening the NT1 diagnostic delay key to reduce disease burden related low quality of life. Here we investigated changes over years (1990– 2018) factors associated in Europe. Patients Methods: We analyzed 580 patients (male: 325, female: 255) from 12 European countries using Network database. combined machine learning...
Recent studies fueled doubts as to whether all currently defined central disorders of hypersomnolence are stable entities, especially narcolepsy type 2 and idiopathic hypersomnia. New reliable biomarkers needed, the question arises current diagnostic criteria should be reassessed. The main aim this data-driven observational study was see algorithms would segregate 1 identify more subgrouping individuals without cataplexy with new clinical biomarkers.We used agglomerative hierarchical...
Abstract Melatonin (MT) is an important plant growth regulator that significantly regulates the and development of plants. Previous studies confirmed effectiveness MT in improving stress tolerance. In this study, annual M9-T337 seedlings were selected as subjects, five treatments applied: control (CK), which only half concentration Hoagland was applied; Saline-alkaline treatment (SA, 100 mmol·L −1 saline-alkaline solution); melatonin (MT, CK + 200 μmol L exogenous MT); (MS, SA inhibitor (HS,...
It is hypothesized that narcolepsy type 1 (NT1) develops in genetically susceptible people who encounter environmental triggers leading to immune-mediated hypocretin-1 deficiency. The pathophysiologies of 2 (NT2) and idiopathic hypersomnia (IH) remain unknown. main aim this study was collect all reported immunological events before onset a central disorder hypersomnolence. Medical records 290 with NT1, 115 NT2 or IH were retrospectively reviewed extract infection influenza vaccination...
Abstract Narcolepsy is a rare life-long disease that exists in two forms, narcolepsy type-1 (NT1) or type-2 (NT2), but only NT1 accepted as clearly defined entity. Both types of narcolepsies belong to the group central hypersomnias (CH), spectrum poorly diseases with excessive daytime sleepiness core feature. Due considerable overlap symptoms and rarity diseases, it difficult identify distinct phenotypes CH. Machine learning (ML) can help learns recognize clinical features invisible for...
The optimization of the 4-methoxy-6-azaindole series HIV-1 attachment inhibitors (AIs) that originated with 1 to deliver temsavir (3, BMS-626529) is described. most beneficial increases in potency and pharmacokinetic (PK) properties were attained by incorporating N-linked, sp2-hybridized heteroaryl rings at 7-position heterocyclic nucleus. Compounds adhered a coplanarity model afforded targeted antiviral potency, leading identification 3 characteristics provided for exposure PK three...
Background: Severe and critically ill COVID-19 patients frequently need pulmonary rehabilitation (PR) after hospitalization. However, little is known about the effectiveness of PR in patients. Methods: We compared performances six-min walk test (6MWT), chronic respiratory questionnaire (CRQ), Functional Independence Measure (FIM) from inpatient between 51 other with common pneumonia. used multivariate linear regression controlled for baseline values at entrance, age, sex, cumulative illness...
In the paper, we introduce a paper reading assistant, PaperHelper, potent tool designed to enhance capabilities of researchers in efficiently browsing and understanding scientific literature. Utilizing Retrieval-Augmented Generation (RAG) framework, PaperHelper effectively minimizes hallucinations commonly encountered large language models (LLMs), optimizing extraction accurate, high-quality knowledge. The implementation advanced technologies such as RAFT RAG Fusion significantly boosts...