A5031359309- 3D Printing in Biomedical Research
- Transgenic Plants and Applications
- Pancreatic function and diabetes
- Pluripotent Stem Cells Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Liver physiology and pathology
- Ethics in Clinical Research
- Telomeres, Telomerase, and Senescence
- Advanced Drug Delivery Systems
- Hemoglobin structure and function
- Eicosanoids and Hypertension Pharmacology
- Statistical Methods in Clinical Trials
- Immune cells in cancer
- Neurological and metabolic disorders
- Toxin Mechanisms and Immunotoxins
- Electrohydrodynamics and Fluid Dynamics
- Adrenal and Paraganglionic Tumors
- Electron Spin Resonance Studies
- BRCA gene mutations in cancer
- Cardiac pacing and defibrillation studies
- Pituitary Gland Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Skin Protection and Aging
- Chronic Obstructive Pulmonary Disease (COPD) Research
Mayo Clinic in Florida
2023-2024
Mayo Clinic in Arizona
2021-2024
Mayo Clinic
2024
University of California, Irvine
2020-2021
University of Colorado Anschutz Medical Campus
2019
University of Colorado Denver
2017
A human single nucleotide polymorphism (SNP) in the matrix‐binding domain of extracellular superoxide dismutase (EC‐SOD), with arginine to glycine substitution at position 213 (R213G), redistributes EC‐SOD from matrix into fluids. We reported that, following bleomycin (bleo), knockin mice harboring R213G SNP (R213G mice) exhibit enhanced resolution inflammation and protection against fibrosis, compared wild‐type (WT) littermates. In this study, we tested hypothesis that promotes via...
The ability to maintain functional hepatocytes has important implications for bioartificial liver development, cell-based therapies, drug screening, and tissue engineering. Several approaches can be used restore hepatocyte function in vitro, including coating a culture substrate with extracellular matrix (ECM), encapsulating cells within biomimetic gels (Collagen- or Matrigel-based), co-cultivation other cells. This paper describes the use of bioactive heparin-based core-shell microcapsules...
Human pluripotent stem cells (hPSCs) are capable of unlimited proliferation and can undergo differentiation to give rise tissues the three primary germ layers. While directing lineage selection hPSCs has been an active area research, improving efficiency remains important objective. In this study, we describe a two-compartment microfluidic device for co-cultivation adult human hepatocytes cells. Both cell types were cultured in 3D or spheroid format. Adult remained highly functional over...
Abstract The predominant approach for antibody generation remains animal immunization, which can yield exceptionally selective and potent clones owing to the powerful evolutionary process of somatic hypermutation. However, immunization is inherently slow, has poor compatibility with certain antigens ( e . g ., integral membrane proteins), suffers from self-tolerance immunodominance, limit functional spectrum antibodies that be obtained. Here, we describe A utonomous H ypermutation y E ast...
Environmental Impedance and Ablation Lesions Introduction The electrical conductivity of the environment surrounding a catheter electrode may affect radiofrequency (RF) current. A higher impedance enveloping tip can be insulating thus direct RF preferentially into targeted cardiac tissue. We sought to evaluate whether different environmental impedances will lesions. Methods An ex vivo model using bovine myocardium, load cell, 4 mm ablation was tested circulating bath normal (0.9%; NS) half...
Concern exists that the clinical trial populations differ from respective cancer in terms of their age distribution affecting generalizability results, especially underrepresented minorities. We hypothesized trials do not report race are likely to suffer a higher degree disparity.Food and Drug Administration (FDA) drug approvals July 2007 June 2019 were reviewed identify oncology approvals, with details selected. The outcomes studied weighted mean difference between population real-world for...
Maintaining the differentiated phenotype and function of primary hepatocytes
Abstract Background: Concern exists that the clinical trial populations differ from respective cancer in terms of their age distribution affecting generalizability results, especially underrepresented minorities. We hypothesized trials do not report race are likely to suffer a higher degree disparity as well and issue should be addressed conjunction with each other. Methods: Food Drug Administration (FDA) drug approvals 7/2007-6/2019 were reviewed identify oncology approvals, details...