A5050144856- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Neuroscience and Neuropharmacology Research
- Extracellular vesicles in disease
- Computational Drug Discovery Methods
- Olfactory and Sensory Function Studies
- Alcohol Consumption and Health Effects
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- Flavonoids in Medical Research
- Neurological Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Biochemical effects in animals
- Nanoplatforms for cancer theranostics
- Regulation of Appetite and Obesity
- Bacterial Infections and Vaccines
- Nanocluster Synthesis and Applications
Hong Kong Baptist University
2017-2025
Karpagam Academy of Higher Education
2023-2025
University of Madras
2013-2017
Czech Academy of Sciences, Institute of Physiology
2015
John Radcliffe Hospital
2012
Alzheimer's disease (AD), characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates, is most common neurodegenerative disorder with limited therapeutic agents. Autophagy plays a critical role in degradation and transcription factor EB (TFEB) master regulator autophagy lysosomal biogenesis. Thus, small-molecule enhancers targeting TFEB hold promise for AD therapy. Here, we found that celastrol, an active ingredient isolated from root extracts Tripterygium...
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in hippocampus and formation amyloid plaques, hyperphosphorylated tau protein, neurofibrillary tangles brain. The overexpression amyloid-β precursor protein (APP) an AD brain results binding APP intracellular domain (AICD) to Fe65 via C-terminal Fe65-PTB2 interaction, which then triggers secretion consequent pathogenesis AD. Apparently, targeting interaction between can...
Abstract Accumulating studies have suggested that targeting transcription factor EB (TFEB), an essential regulator of autophagy‐lysosomal pathway (ALP), is promising for the treatment neurodegenerative disorders, including Alzheimer's disease (AD). However, potent and specific small molecule TFEB activators are not available at present. Previously, we identified a novel activator named curcumin analog C1 which directly binds to activates TFEB. In this study, systematically investigated...
Accumulation of amyloid-β (Aβ) oligomers and phosphorylated Tau aggregates are crucial pathological events or factors that cause progressive neuronal loss, cognitive impairments in Alzheimer's disease (AD). Current medications for AD have failed to halt, much less reverse this neurodegenerative disorder; therefore, there is an urgent need the development effective safe drugs therapy. In present study, vivo therapeutic efficacy Aβ-oligomer-targeted fluorescent probe, F-SLOH, was extensively...
Aspartame, an artificial sweetener, is very widely used in many foods and beverages. But there are controversies about its metabolite which marked for toxicity. Hence it believed to be unsafe human use. Previous studies have reported on methanol exposure with involvements of free radicals excitotoxicity neuronal apoptosis. Hence, this present study proposed investigate whether or not chronic aspartame (FDA approved Daily Acceptable Intake (ADI),40 mg/kg bwt) administration could release...
Alzheimer disease (AD) is the most common neurodegenerative characterized by deposition of amyloid plaque in brain. The autophagy-associated PIK3C3-containing phosphatidylinositol 3-kinase (PtdIns3K) complex has been shown to interfere with APP metabolism and beta peptide (Aβ) homeostasis via poorly understood mechanisms. Here we report that NRBF2 (nuclear receptor binding factor 2), a key component regulator PtdIns3K, involved APP-CTFs AD cell models. We found interacts vivo its expression...
Abstract Background Tauopathies are neurodegenerative diseases that associated with the pathological accumulation of tau-containing tangles in brain. Tauopathy can impair cognitive and motor functions has been observed Alzheimer’s disease (AD) frontotemporal dementia (FTD). The aetiology tauopathy remains mysterious; however, recent studies suggest autophagic-endolysosomal function plays an essential role degradation transmission tau. We previously demonstrated tetrandrine could ameliorate...
TFEB (transcription factor EB) and TFE3 E3) are "master regulators" of autophagy lysosomal biogenesis. The stress response p38 mitogen-activated protein (MAP) kinases affect multiple intracellular responses including inflammation, cell growth, differentiation, death, senescence, tumorigenesis, autophagy. Small molecule MAP kinase inhibitors such as SB202190 widely used in dissection related signal transduction mechanisms redox biology Here, we initially aimed to investigate the links between...
Abstract: TFEB (transcription factor EB), which is a master regulator of autophagy and lysosome biogenesis, considered to be new therapeutic target for Parkinson's disease (PD). However, only several small-molecule activators have been discovered their neuroprotective effects in PD are unclear. In this study, curcumin derivative, named E4, was identified as potent activator. Compound E4 promoted the translocation from cytoplasm into nucleus, accompanied by enhanced lysosomal biogenesis....
Impairment of the macroautophagy/autophagy-lysosomal pathway (ALP) can lead to amyloid plaque accumulation in Alzheimer disease (AD); however, underlying mechanism remains unresolved. This study revealed a ALP impairment mediated by gain-of-function lysosomal TPCN2/TPC2 (two pore segment channel 2) and suggests molecular target for AD intervention. Using mutant PSEN1/PS1 (presenilin 1)-expressing human neuroblastoma SH-SY5Y familial fibroblasts collected from patients, we showed pH was...