A5027822882- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Immune cells in cancer
- Advanced Glycation End Products research
- Inflammatory Biomarkers in Disease Prognosis
- Immune Response and Inflammation
Southeast University
2023
Nanjing General Hospital of Nanjing Military Command
2023
Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a primary catalyst for microcirculation dysfunction and enterogenous infection. Previous studies have mainly focused on how neutrophil extracellular traps (NETs) ferroptosis cause epithelial injury, little attention has been given to NETs, from circulatory neutrophils, affect cells during II/R. This study aimed unravel the mechanisms through which NETs microvascular dysfunction. We first detected heightened...
Background: Hesperetin (HES), one of the major flavonoids that has various biological activities, such as anti-inflammatory and antioxidant may preserve intestinal barrier during sepsis. However, detailed mechanism remains unclear. Our previous studies confirmed neutrophil extracellular traps (NETs) jeopardize via a reactive oxygen species (ROS)-dependent pathway Therefore, we hypothesized HES inhibit NET formation protect function Methods: Mice were pretreated with (50 mg kg-1)...
Abstract Neutrophil extracellular trap (NET) has been confirmed to be related gut barrier injury during intestinal ischaemia–reperfusion (II/R). However, the specific molecular regulatory mechanism of NETs in II/R‐induced damage yet fully elucidated. Here, we reported increased infiltration accompanied by elevated inflammatory cytokines, cellular necroptosis and tight junction disruption intestine human II/R patients. Meanwhile, aggravated Caco‐2 epithelial cell necroptosis, impairing...