A5036005197- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Bone Tumor Diagnosis and Treatments
- Gastric Cancer Management and Outcomes
- Cardiac tumors and thrombi
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Sarcoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Prostate Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Radiation Dose and Imaging
- Cerebrospinal fluid and hydrocephalus
Memorial Sloan Kettering Cancer Center
2020-2025
To determine the safety and efficacy of adding anti-PD-L1 antibody durvalumab to induction FOLFOX preoperative chemotherapy in locally advanced esophageal adenocarcinoma.
Abstract Background Dose escalation radiotherapy enables increased control of prostate cancer (PCa) but requires segmentation dominant index lesions (DIL). This motivates the development automated methods for fast, accurate, and consistent PCa DIL. Purpose To construct validate a model deep‐learning‐based automatic DIL defined by Gleason score (GS) ≥3+4 from MR images applied to MR‐guided radiation therapy. Validate generalizability constructed models across scanner acquisition differences....
4029 Background: Induction FOLFOX followed by PET-directed CRT prior to surgery demonstrated positive results in the CALGB 80803 study. We investigated safety and efficacy of adding D, an anti-PD-L1 antibody, CRT. Methods: Patients (pts) with locally advanced esophageal/GEJ adenocarcinoma were enrolled. Pts received 2 cycles mFOLFOX6 repeat PET/CT. PET responders (≥35% reduction SUV (PETr)) 5-FU/capecitabine oxaliplatin RT 50.4Gy, while induction non-responders (PETnr) carboplatin/paclitaxel...
Abstract A 62-year-old man, previously treated for oral cavity carcinoma, presented with new-onset cognitive-motor symptoms. Brain MRI revealed a periventricular, avidly enhancing lesion in the right anterior basal ganglia and hypothalamus suspicious brain tumor, particularly CNS lymphoma. 18 F-FDG PET/CT showed corresponding uptake suggestive of primary lymphoma, or metastasis. Follow-up resolution enhancement mass effect favoring an evolving subacute infarct. The diagnosis infarct...
Abstract BACKGROUND Studies have shown that diffusion-weighted imaging (DWI) derived apparent diffusion coefficient (ADC) measurements inversely correlate with tumor cell density and may prognostic value in newly-diagnosed CNS lymphoma patients. This study characterizes ADC a relapsed/refractory population describes the potential of these METHODS were assessed immunocompetent patients enrolled on prospective clinical trial studying ibrutinib-based treatment recurrent/refractory (NCT02315326;...