A5100655176- Bone Metabolism and Diseases
- Antimicrobial Peptides and Activities
- Orthopaedic implants and arthroplasty
- Bacteriophages and microbial interactions
- DNA Repair Mechanisms
- Extraction and Separation Processes
- Minerals Flotation and Separation Techniques
- MicroRNA in disease regulation
- Photoreceptor and optogenetics research
- Biochemical and Structural Characterization
- Ferroptosis and cancer prognosis
- Bacterial biofilms and quorum sensing
- Retinal Development and Disorders
- Metal Extraction and Bioleaching
- Bone Tissue Engineering Materials
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Musculoskeletal synovial abnormalities and treatments
- Antimicrobial agents and applications
- Circular RNAs in diseases
- Seaweed-derived Bioactive Compounds
- Lower Extremity Biomechanics and Pathologies
- Microtubule and mitosis dynamics
- Particle Dynamics in Fluid Flows
- Neurogenetic and Muscular Disorders Research
Shanghai Jiao Tong University
2012-2023
Shanghai First People's Hospital
2023
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2023
Harbin Medical University
2022-2023
Second Affiliated Hospital of Harbin Medical University
2022-2023
Ningxia Medical University
2013-2021
Baylor College of Medicine
2014
Institute of Process Engineering
2014
Shanghai Sixth People's Hospital
2012-2013
Tulane University
2012-2013
Retinal photoreceptors are highly differentiated postmitotic neurons that transduce photons into electrical signals. While the functions of many photoreceptor-specific genes can be evaluated by direct gene targeting, here we facilitate studies nonphotoreceptor-specific in these cells developing an Opsin-iCre transgenic mouse line, iCre-75, which a 4-kb rod opsin promoter drives expression bacteriophage P1 Cre recombinase. Immunohistochemical analysis demonstrated recombinase is present...
Autism spectrum disorder (ASD) is a severe neurodevelopment disorder. This study tests the hypothesis that children with ASD show atypical intrinsic complexity of brain activity. Electroencephalogram data were collected from boys and matching normal typically developing while performing an observation imitation task. The multiscale entropy was estimated within 0.5-30 Hz frequency band over 30 time scales using coarse-grained procedure. A decreased electroencephalogram observed in both during...
Light-dependent redistribution of transducin between the rod outer segments (OS) and other photoreceptor compartments including inner (IS) synaptic terminals (ST) is recognized as a critical contributing factor to light dark adaptation. The mechanisms light-induced translocation IS/ST its return OS during adaptation are not well understood. We have probed these by examining light-dependent localizations transducin-alpha subunit (Gtalpha)in mice lacking GAP-protein RGS9, or expressing...
The aim of the present study was to predict and analyze secondary structure, B T cell epitopes
Low-molecular-weight heparin (LMWH) and fondaparinux sodium (FPX) are routinely used to prevent deep vein thrombosis (DVT) after total knee arthroplasty (TKA). In this study, we compared the effects of these agents in preventing post-TKA DVT.Clinical data patients who underwent unilateral TKA for unicompartmental osteoarthritis at Ningxia Medical University General Hospital between September 2021 June 2022 were retrospectively analyzed. Based on anticoagulation agent used, divided into LMWH...
Mammalian β-defensins are small cationic peptides of approximately 2-6 kDa that have been implicated in mediating innate immune defenses against microbial infection. Previous studies reported mouse β-defensin-14 (MBD‑14), based on structural and functional similarities, appears to be an ortholog human β-defensin-3 (HBD-3). The aim this study was identify the signaling pathways contribute expression MBD-14 osteoblasts (OBs) upon contact with methicillin-resistant Staphylococcus aureus (S....
Staphylococcus aureus (S. aureus) is the principle causative agent of osteomyelitis, accounting for 80% all human cases. S. internalized in osteoblasts escapes immune response, including engulfment by phagocytes. It also action a number antibiotics. Ultrasound increases cell membrane permeability to drugs. Following an internalization assay, we used low-frequency, low-power ultrasound combined with antibiotic rifampin target osteoblasts. Tryptic soy agar (TSA) was quantitate antibacterial...
Osteoarthritis (OA) is related to over‑proliferation or differentiation of osteoclasts. Although protocatechuic acid (PCA) has been identified inhibit osteoclast and stimulate apoptosis in mature osteoclasts, whether it can relieve OA still unknown. The present study aimed investigate the effect PCA on anterior cruciate ligament transection (ACLT)‑induced potential mechanisms action behind this effect. ACLT was performed rats, which were then treated with without PCA. C‑terminal telopeptide...
Peri-implant osteolysis (PIO) and the subsequent aseptic loosening are main reasons for artificial joint implant failure. Existing methods treating far from satisfactory, necessitating advanced drug exploration. This study is aimed at investigating effect underlying mechanism of tetrandrine (Tet) on inflammatory osteolysis. We established a Ti particle-induced mouse model administered Tet or an equal volume phosphate-buffered saline (PBS). Two weeks later, specimens were collected....
Glioma is the most common and fatal primary brain tumor in humans. A significant role for long non-coding RNA (lncRNA) glioma regulation of gene expression chromatin recombination, immunotherapy a promising cancer treatment. Therefore, it necessary to identify necroptosis-related lncRNAs glioma. In this study, we collected evaluated RNA-sequencing (RNA-seq) data from The Cancer Genome Atlas (TCGA, https://www.ncbi.nlm.nih.gov/, Data Release 32.0, March 29, 2022) patients, were screened. Cox...
Introduction: Although the molecular mechanisms of Krüpple-like factor 4 (KLF4) as a tumor suppressor in HCC tumorigenesis have been thoroughly examined, its clinical application terms precise prognostication and influence on immune microenvironment patients with require further investigation. Methods : Bioinformatics immunohistochemistry (IHC) were used to validate KLF4 expressions tissue microarray (TMA) containing samples. Using Cox regression models, independent prognostic factors...
Establishment of an in vitro osteoclast induction model under nuclear factor-κB receptor activator ligand (RANKL) for investigating the effect metformin hydrochloride (Met) on differentiation. RANKL induced differentiation mouse bone marrow macrophages (BMMs) into osteoclasts vitro, and Met was added at different concentrations intervention during process. After 5 d culture fixation, number counted by tartrate-resistant acid phosphatase (TRAP) staining F-actin staining, function examined...
Human DNA polymerase (pol) β is essential for base excision repair. We previously reported a triple somatic mutant of pol (p.P261L/T292A/I298T) found in an early onset prostate tumor. This mutation abolishes activity, and the wild-type allele was not present tumor, indicating complete deficiency function. The effect on activity unexpected because point mutations that comprise are part active site. Herein, we demonstrate mechanism this loss-of-function. In order to understand individual...