A5082970055- Catalytic C–H Functionalization Methods
- Synthesis and Characterization of Pyrroles
- Radical Photochemical Reactions
- Multicomponent Synthesis of Heterocycles
- Catalytic Alkyne Reactions
- Catalytic Cross-Coupling Reactions
- Perovskite Materials and Applications
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Organic Electronics and Photovoltaics
- Synthesis and Catalytic Reactions
- X-ray Diffraction in Crystallography
- Conducting polymers and applications
- Click Chemistry and Applications
- Crystallization and Solubility Studies
- Carbon dioxide utilization in catalysis
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Vibration and Dynamic Analysis
- Geotechnical Engineering and Underground Structures
- Synthesis of Indole Derivatives
- Fluid Dynamics and Vibration Analysis
- Cyclopropane Reaction Mechanisms
- Crystallography and molecular interactions
- Asymmetric Hydrogenation and Catalysis
Guangdong University of Technology
2023-2025
Qufu Normal University
2018-2024
Ocean University of China
2021
Jiaxing University
2019
Zhejiang University
2015
This review focuses on the cyanation of isocyanides with recent advances and perspectives.
In this work, an unprecedented route is described for the synthesis of 2-amino-4-cyanopyrrole derivatives via palladium-catalyzed reductive isocyanide insertion alkynyl imines. reactions, no external reductant added and plays a dual role as both C1 synthon imidoylation cyano source cyanation. Mechanism studies suggest [4 + 1] cycloaddition, insertion, β-carbon elimination, palladium hydride-based reduction are involved. Moreover, application 2-amine-4-cyanopyrroles cysteine probe realized to...
Abstract Nitrogen‐containing heterocycles have attracted considerable attention due to their extensive applications in the fields of organic synthesis, pharmaceuticals, agrochemicals, and materials science. This review focuses on recent advances synthesis nitrogen‐containing via cyclization alkynyl imines. By using this protocol, a variety heterocycles, mainly including four‐, five‐, six‐, seven‐membered aza‐spirocycles, fused aza‐heterocycles, could be obtained efficiently under mild...
A palladium-catalyzed tandem reaction of <italic>N</italic>-(2-iodophenyl)-4-methyl-<italic>N</italic>-(propa-1,2-dien-1-yl)benzenesulfonamide with isocyanide is described to divergently produce aza-heterocyclic amides.
This review summarizes recent advances in the use of isocyanide as “C1N1” synthons cyclization.
Controlling the morphology and phase separation of active layer is great significance for development efficient organic solar cells. This study employs ternary copolymerization to optimize surface layer. Three terpolymers (PMz-5, PMz-10, PMz-20) are synthesized by incorporating an asymmetric benzo[d]thiazole (BTz) unit as third component suppress strong aggregation PM6:L8-BO blend film. Compared PM6 film, terpolymer films exhibit improved morphology, appropriate scale, and, thus, enhanced...
In this work, a palladium-catalyzed cyclization of alkynylimines and double isocyanides is described. This facile procedure efficient for synthesizing various 4-amidyl-2-aminopyrroles. Mechanism investigation indicates that four-membered ring-fused pyrrole species key intermediate the reaction involves [4 + 1] cycloaddition, protonation, nucleophilic addition, 1,4-addition isocyanide, rearomatization. Interestingly, linear dipyrrole derivative found to be an appropriate fluoride ion probe...
Abstract This paper describes the development of a facile protocol to highly functionalized amidoallenylium by treatment alkynylimine with acyl bromide in dichloromethane, which may give tetrasubstituted allene intermediates and yield furans, pyrroles, thiophenes, benzofurans benzothiophenes. The plausible mechanism was discussed reaction intermediate isolated. With stereoselective transformation efficient conversion versatile heterocyclic compounds, this will be useful organic medicinal...
An unprecedented route for the preparation of indole–isoindole derivatives was developed and proceeds via a palladium-catalyzed [3+2] cyclization isocyanides with alkynyl imines.
An efficient one-pot approach for the synthesis of polyfunctionalized quinolines was developed <italic>via</italic> a sequence copper-catalyzed coupling reaction/propargyl-allenyl isomerization/aza-electrocyclization.
An unprecedented route for the preparation of fused tetracyclic N-heterocycles is presented through palladium-catalyzed cyclization isocyanides with alkyne-tethered aryl iodides. In this transformation, a novel amino-to-alkyl 1,5-palladium migration/intramolecular C(sp3)-C(sp2) coupling sequence was observed first. More importantly, isocyanide exhibited three roles, serving simultaneously as C1 synthon, C1N1 and donor C(sp3) coupling, reaction sole successful example that achieved C(sp3)-H...
A novel halogen-radical-promoted dearomative aza-spirocyclization of alkynylimines for the synthesis 3-halo-spirocyclohexadienones is described. In this process, it believed that a radical addition, 5-exo-trig cyclization, and aza-spirocyclization are involved. Easily available starting materials, mild conditions, wide substrate scope make approach potentially useful.
A tandem oxidative radical halogenated addition of alkynyl imines for regioselective synthesis 3‐haloquinolines is described. Mechanism investigation suggests that the oxidation halogen, 6‐ endo ‐ trig cyclization and aromatization are involved in process. Easily available starting materials, mild conditions, a wide substrate scope make this approach potentially useful.
A highly efficient palladium-catalyzed TBD–formate system for carbonylation/hydrogenation was reported.
A novel approach for the production of halogen cations through reaction halogens with silver ions is described in this paper. On basis, regioselective synthesis 3-haloquinolines and 3-halospirocyclohexadienones realized solvent regulation. The gram-scale compatibility complex substrates demonstrate synthetic potential protocol, which will be an appealing strategy organic synthesis.
Abstract An efficient route for the synthesis of polysubstituted pyrrole derivatives via a copper‐catalyzed three‐component reaction was described. Easily available starting materials, mild conditions, and wide substrate scope make this approach potentially useful.