A5054415920- Neuroscience and Neural Engineering
- Advanced Sensor and Energy Harvesting Materials
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Advanced Materials and Mechanics
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Nerve injury and regeneration
- Electrochemical Analysis and Applications
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Bone Tissue Engineering Materials
- Advanced Memory and Neural Computing
- Luminescence Properties of Advanced Materials
- Muscle activation and electromyography studies
- Metal-Organic Frameworks: Synthesis and Applications
- Nanoparticles: synthesis and applications
- Multisensory perception and integration
- Cellular Mechanics and Interactions
- Conducting polymers and applications
- Vagus Nerve Stimulation Research
- Microfluidic and Bio-sensing Technologies
- Silk-based biomaterials and applications
Technical University of Munich
2020-2025
Abstract Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently existing electrodes present challenges to the procedure, which limit their application, in particular, when targeting small peripheral nerves (<200 µm). To improve electrode handling and implantation, interface that can fold itself cuff around nerve, triggered by body moisture during insertion, is fabricated. This folding achieved...
The human brain is a complex and poorly accessible organ. Thus, new tools are required for studying the neural function in controllable environment that preserves multicellular interaction neuronal wiring. In particular, high-throughput methods alleviate need animal experiments essential future studies. Recent developments of induced pluripotent stem cell technologies have enabled vitro modeling by creating three-dimensional tissue mimic structures. To leverage these technologies, systematic...
Three-dimensional ring electrode arrays can provide means for highly-parallelized nanoparticle-impact electrochemistry within bulk solution.
The successful development of a metal–organic framework (MOF)-derived Co/Co3O4/C core–shell composite integrated into laser-induced graphitic (LIG) carbon electrodes for electrochemical sensing is reported. sensors are fabricated via direct laser scribing technique using UV (355 nm wavelength) to induce the photothermolysis rationally selected ZIF-67 LIG matrix. Electrochemical characterization reveals that incorporation laser-scribed ZIF-67-derived on electrode surface reduces impedance...
We present a photocurable, biocompatible, and flexible silicone-hydrogel hybrid material for stereolithographic (SLA) printing of biomedical devices. The polymer is similar to mixtures used contact lenses. It stretchable with Young's modulus 78 MPa maximum elongation at break 51%, shows low degree swelling (<4% v/v) in water, can be bonded easily flat glass substrates via surface-modification method. vitro cytotoxicity the assessed WST-8 cell viability assay using five different lines:...
Abstract Thin film electronic devices based on flexible biocompatible substrates are desired in various fields such as implants, soft robotics, and wearables, where stretchability is often necessary. Structure‐enabled thin films can be achieved by introducing origami‐inspired folds, thereby storing excess material the out‐of‐plane direction to unfold upon stress. When using vapor‐deposited parylene‐C, folds introduced prefabrication molds patterned repeated grooves ridges. Here, this work...
A multiscale approach for characterizing the thermomechanical performance of photothermally powered, nanorobotic microgels is presented.
Abstract Superabsorbent polymers are materials that exhibit a high swelling behavior in liquids and can hold the absorbed liquid even against externally applied pressure. They commercially used, for example, baby diapers, fake snow, or swellable children's toys. Most available superabsorbent based on polymerized crosslinked sodium acrylate. Here, material formulation to create 3D objects using stereolithographic printing of acrylate is demonstrated. The shows typical properties cannot be...
Abstract In this study, the novel 3D‐printed pressure chamber for encapsulated single‐cell stimulation (3D‐PRESS) platform is introduced mechanical of single stem cells in 3D microgels. The custom‐designed 3D‐PRESS, allows precise application up to 400 kPa at level. Microfluidics employed encapsulate mesenchymal within ionically cross‐linked alginate microgels with cell adhesion RGD peptides. Rigorous testing affirms leak‐proof performance 3D‐PRESS device kPa, which fully biocompatible....
Virtual reality environments offer great opportunities to study the performance of brain-computer interfaces (BCIs) in real-world contexts. As stimuli are typically multimodal, their neuronal integration elicits complex response patterns. To investigate effect additional auditory cues on processing visual information, we used virtual mimic safety-related events an industrial environment while concomitantly recorded electroencephalography (EEG) signals. We simulated a box traveling conveyor...
Abstract Activity of an innervated tissue can be modulated based on acquired biomarker through feedback loops. How to convert this into a meaningful stimulation pattern is still topic intensive research. In article, we present simple closed-loop mechanism control the mean angle locust’s leg in real time by modulating frequency its extensor motor nerve. The nerve interfaced with custom-designed cuff electrode and loop implemented online proportional algorithm, which runs solely...
Abstract With the ever‐growing presence of silver nanoparticles in consumer products, there is a need for cost‐effective and on‐site monitoring their influence on our environment. Herein, we report use screen‐printed laser‐ablated microelectrode arrays (SPMEAs) electrochemical detection 20 nm‐sized (AgNPs) via collision electrochemistry. The electrodes’ morphology optically analyzed properties later characterized using cyclic voltammetry impedance spectroscopy. SPMEAs are calibrated AgNP...
Self-Folding Electrodes In article number 2210206, Lukas Hiendlmeier, Francisco Zurita, Bernhard Wolfrum, and co-workers present a new method for fabricating small, soft, stretchable cuff electrodes that fold change shape when submerged in an aqueous environment. Just like hand closes its fingers grasping, these structures wrap around peripheral nerves, greatly simplifying the process of nerve interfacing at small scale.
Abstract Minimizing damage during the insertion of stents or other medical devices is critical for rapid and successful recovery. Since delivery passages are often narrower than size delivered object, a high deformability implanted paramount to achieve smooth into target tissue. In this study, novel design 3D‐printable highly deformable structures inspired by Nanjing Tamasudare proposed. These rapidly change dimensionality from flat linear, elongated shapes. A series single units that each...
Peripheral nerve interfacing plays a crucial role in various healthcare applications. Generally, peripheral nerves results compromise between selectivity and invasiveness. In particular, large carry many axonal fibers, which are difficult to address selectively without penetrating the nerve. Higher penetration can be achieved by targeting small with extraneural cuff electrodes. However, practice, challenging interface appropriately. Herein, new multielectrode device is presented that...
Epoxy-based 3D microelectrode arrays facilitate extracellular recordings in non-planar environments.
Abstract The investigation of a skin adhesive based on amylopectin and mastic gum for attaching sensors are reported. material provides reliable adhesion is, at the same time, readily washable from due to hydrophilic character compound. effect water glycerol content properties in combination with polyimide‐based substrates is assessed optimize homogeneous on‐skin applications. This results show that can withstand shear stress 88.7 ± 5.30 kPa lap test. also be easily rendered conductive by...