A5020044242- Cosmology and Gravitation Theories
- Black Holes and Theoretical Physics
- Particle physics theoretical and experimental studies
- Dark Matter and Cosmic Phenomena
- Geophysics and Gravity Measurements
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Neutrino Physics Research
- Quantum Chromodynamics and Particle Interactions
- Pulsars and Gravitational Waves Research
- Astrophysics and Cosmic Phenomena
- Protein purification and stability
- Solar and Space Plasma Dynamics
- Advanced Database Systems and Queries
- Astrophysical Phenomena and Observations
- Liquid Crystal Research Advancements
- Advanced Proteomics Techniques and Applications
- Interactive and Immersive Displays
- Polymer Nanocomposites and Properties
- Astronomy and Astrophysical Research
- BIM and Construction Integration
- Electrochemical Analysis and Applications
- Polymer crystallization and properties
- Big Data and Business Intelligence
- Biosimilars and Bioanalytical Methods
Wake Forest University
2002-2025
Protein Metrics (United States)
2015-2022
University of California, Berkeley
1989-2020
Berkeley College
2020
University of Colorado Boulder
2015-2019
University of Manchester
2014-2018
Manchester Academic Health Science Centre
2014-2015
Florida Atlantic University
2010
Brigham Young University
2002-2004
Princeton University
2003
view Abstract Citations (319) References (11) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Self-interacting Dark Matter Carlson, Eric D. ; Machacek, Marie E. Hall, Lawrence J. A new type of dark matter is considered. As with cold matter, when the nonrelativistic, it does not couple to electron-photon plasma, so its entropy per comoving volume fixed. The feature that there a cosmological era where number-changing reactions keep in chemical equilibrium...
Charge deconvolution infers the mass from over charge (m/z) measurements in electrospray ionization spectra. When applied a wide input m/z or broad target range, charge-deconvolution algorithms can produce artifacts, such as false masses at one-half one-third of correct mass. Indeed, maximum entropy term objective function MaxEnt, most commonly used algorithm, favors deconvolved spectrum with many peaks one fewer peaks. Here we describe new "parsimonious" algorithm that produces artifacts....
In April 2016, the Food and Drug Administration approved first biosimilar monoclonal antibody (mAb), Inflectra/Remsima (Celltrion), based off original product Remicade (infliximab, Janssen). Biosimilars promise significant cost savings for patients, but unavoidable differences between innovator copycat biologics raise questions regarding interchangeability. this study, Remsima were examined by native mass spectrometry, ion mobility, quantitative peptide mapping. The levels of oxidation,...
Studies of specific decisions and general studies decision making have indicated the potential benefits computer support for making. These can be divided into two categories: displaced cost added value.
The effect of Wolfenstein neutrino-oscillation enhancement on atmospheric neutrinos is considered. these neutrino oscillations data from proton-decay experiments discussed. It found that for \ensuremath{\Delta}${M}^{2}$\ensuremath{\sim}${10}^{\mathrm{\ensuremath{-}}3}$--${10}^{\mathrm{\ensuremath{-}}4}$ ${\mathrm{eV}}^{2}$ and ${\mathrm{sin}}^{2}$(2theta)\ensuremath{\ge}3\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}2}$,...
The Kidney Disease: Improving Global Outcomes (KDIGO) Acute Injury (AKI) guidelines assign the same stage of AKI to patients whether they fulfil urine output criteria, serum creatinine criteria or both for that stage. This study explores validity KDIGO as a tool stratify risk adverse outcomes in cardiac surgery patients. Prospective data from consecutive adult admitted intensive care unit (CICU) following between January 2013 and May 2015 were analysed. Patients assigned groups based on met...
We study $f(R,T)$ gravity, in which the curvature $R$ appearing gravitational Lagrangian is replaced by an arbitrary function of and trace $T$ stress-energy tensor. focus primarily on situations where $f$ separable, so that $f(R,T)={f}_{1}(R)+{f}_{2}(T)$. argue term ${f}_{2}(T)$ should be included matter ${\mathcal{L}}_{m}$, therefore has no physical significance. demonstrate explicitly how this can done for cases free fields perfect fluids. all uses cosmological modeling attempts to place...
Glycopeptides in peptide or digested protein samples pose a number of analytical and bioinformatics challenges beyond those posed by unmodified peptides with smaller posttranslational modifications. Exact structural elucidation glycans is generally the capability single mass spectrometry experiment, so reasonable level identification for tandem spectrometry, taken several glycopeptide software tools, that sequence glycan composition, meaning monosaccharides each distinct mass, e.g.,...
The Multi-Attribute Method (MAM) Consortium was initially formed as a venue to harmonize best practices, share experiences, and generate innovative methodologies facilitate widespread integration of the MAM platform, which is an emerging ultra-high-performance liquid chromatography–mass spectrometry application. Successful implementation purity-indicating assay requires new peak detection (NPD) potential process- and/or product-related impurities. NPD interlaboratory study described herein...
Current methods of evolving a spacetime containing one or more black holes are plagued by instabilities that prohibit long-term evolution. Some these may be due to the numerical method used, traditionally finite differencing. In this paper, we explore use pseudospectral collocation (PSC) for evolution spherically symmetric hole in dimension using hyperbolic formulation Einstein's equations. We demonstrate our PSC is able evolve forever without enforcing constraints, even if add dynamics via...
Remsima™ (infliximab) is the first biosimilar monoclonal antibody (mAb) approved by European Medical Agency and US Food Drug Administration. highly similar to its reference product, Remicade®, with identical formulation components. The 2 products, however, are not identical; has higher levels of soluble aggregates, C-terminal lysine truncation, fucosylated glycans. To understand if these attribute differences could be amplified during forced degradation, solutions lyophilized powders...
We investigate changes in Earth's atmospheric models coming from the $f(R,T)$ modified theory of gravity, which gravitational Lagrangian is given by an arbitrary function Ricci scalar and trace stress-energy tensor. obtain a generic form for field equations derive hydrostatic equation atmosphere leading order terms $f(R,T)=R+2\ensuremath{\chi}T$. Based on apparent accuracy 1976 U.S. Standard Atmosphere model, varies no more than 10% observations, we find limits...
Here we describe a state-of-the-art, integrated, multi-instrument automated system designed to execute methods involved in mass spectrometry characterization of biotherapeutics. The includes liquid and microplate handling robotics utilities, integrated LC-MS, along with data analysis software, perform sample purification, preparation, as seamless unit. process begins tip-based purification target proteins from expression cell-line supernatants, which is initiated once the samples are loaded...
Interactive problem-solving is defined as user/machine dialogues to identify and solve problems with imprecise solution criteria. Although high payoffs from interactive systems have been predicted, few such are in use. A key problem the lack of understanding requirements potential users. This paper presents results case studies use an system. Based on observations these studies, a list user characteristics compiled relating behavior (e.g., data solving methods) need for involvement process).
The properties of elastomeric polypropylene synthesized from an unbridged metallocene catalyst are investigated by mechanical rheometry, differential scanning calorimetry, and optical depolarization. material is compositionally heterogeneous in tacticity, its behavior compared to that solvent fractions. also with tacticity-matched atactic/isotactic homopolymer blends. For T below Tm, rheometry shows forms a more constrained network than Differential calorimetry reveals the samples...
The effects which quantum fields and an $\alpha_0 R^2$ term in the gravitational Lagrangian have on future singularities are investigated. While all values of $\alpha_0$ considered, emphasis is placed those compatible with universe having undergone Starobinsky inflation past. These also lead to stable solutions semiclassical backreaction equations present universe. dark energy modeled as a perfect fluid, focus type I-IV little rips result when classical Einstein solved various types source....
A number of contemporary risk prediction models for mortality following elective abdominal aortic aneurysm (AAA) repair have been developed. Before a model is used either in clinical practice or to risk-adjust surgical outcome data it important that its performance assessed external validation studies.The British Aneurysm Repair (BAR) score, Medicare, and Vascular Governance North West (VGNW) were validated using an independent prospectively collected sample multicentre audit data....