A5076329444- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Hydrogen's biological and therapeutic effects
- Cancer-related molecular mechanisms research
- Telomeres, Telomerase, and Senescence
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- Chromatin Remodeling and Cancer
- Genomics and Chromatin Dynamics
German Cancer Research Center
2010-2015
Heidelberg University
2010-2015
DKFZ-ZMBH Alliance
2011-2013
Epigenetic changes are widely considered to play an important role in aging, but experimental evidence support this hypothesis has been scarce. We have used array-based analysis determine genome-scale DNA methylation patterns from human skin samples and investigate the effects of chronic sun exposure, tissue variation. Our results reveal a high degree specificity also showed very little interindividual variation within tissues. Data stratification by age revealed that older individuals was...
Early and progressive colonization of the healthy brain is one hallmark diffuse gliomas, including glioblastomas. We recently discovered ultralong (>10 to hundreds microns) membrane protrusions [tumor microtubes (TMs)] extended by glioma cells. TMs have been associated with capacity cells effectively invade proliferate. Moreover, are also used some tumor interconnect large, resistant multicellular network. Here, we performed a correlative gene-expression microarray <i>in vivo</i> imaging...
The DNA methyltransferase inhibitors azacytidine and decitabine represent archetypal drugs for epigenetic cancer therapy. To characterize the demethylating activity of we treated colon leukemic cells with both used array-based methylation analysis more than 14,000 gene promoters. Additionally, drug-induced demethylation was compared to patterns isogenic lacking 1 (DNMT1) DNMT3B. We show that are highly specific, non-random reproducible, indicating targeted remethylation specific loci after...
Tumor metastasis continues to be the most significant contributor cancer related mortality, and although several studies have examined expression profiles emanating from patients with metastatic disease, very little information is available about signatures that differentiate lesions primary tumors associated normal tissues, largely because such matched tissue sample series are rare. This study was specifically designed identify relevant microRNAs in colorectal characterize modulate...