A5100733465- Signaling Pathways in Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Apelin-related biomedical research
- Neuropeptides and Animal Physiology
- Nuclear Receptors and Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nitric Oxide and Endothelin Effects
- Cardiac Fibrosis and Remodeling
- Protein purification and stability
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Hemoglobin structure and function
- Caveolin-1 and cellular processes
- Ultrasound and Hyperthermia Applications
University of South China
2011-2020
The aim of this study was to investigate the role apelin in cell proliferation and autophagy lung adenocarcinoma. over-expression APJ adenocarcinoma detected by immunohistochemistry, while plasma level cancer patients measured enzyme-linked immunosorbent assay. Our findings revealed that apelin-13 significantly increased phosphorylation ERK1/2, expression cyclin D1, microtubule-associated protein 1 light chain 3A/B (LC3A/B), beclin1, confirmed promoted A549 induced via ERK1/2 signaling....
Abstract Rutaecarpine attenuates hypertensive cardiac hypertrophy in the rats with abdominal artery constriction (AAC); however, its mechanism of action remains largely unknown. Our previous study indicated that NADPH oxidase 4 (Nox4) promotes angiotensin II (Ang II)‐induced through pathway between reactive oxygen species (ROS) and a disintegrin metalloproteinase‐17 (ADAM17) primary cardiomyocytes. This research aimed to determine whether Nox4‐ROS‐ADAM17 is involved protective rutaecarpine...
NADPH oxidases (Noxs) 1/4 dual inhibitor GKT137831 prevents hypertensive cardiac remodelling in angiotensin II-infused transgenic mice with cardiomyocyte-specific human Nox4 (c-hNo x 4 Tg); however, further research is still required to determine the beneficial role of other types models because this model insufficient mimic complicated pathological mechanisms hypertension. A disintegrin and metalloprotease 17 (ADAM17) promotes shedding tumour necrosis factor α (TNF-α), TNF-α receptor,...
Calcitonin gene-related peptide (CGRP) has a potent protective action on the cardiovascular system; however, little is known about role of CGRP in angiotensin II- (Ang II-) induced inflammation vascular smooth muscle cells (VSMCs). This study aimed at determining anti-inflammatory effect Ang II-treated VSMCs and whether disintegrin metalloproteinase 17 (ADAM17) modulates this action. Small interference RNA (siRNA) inhibitors CGRP, epidermal growth factor receptor (EGFR), extracellular...
Oxidative stress, inflammation, and hypertension constitute a self-perpetuating vicious circle to exacerbate subsequent hypertensive cardiac hypertrophy. NADPH oxidase (Nox) 1/4 inhibitor GKT137831 alleviates hypertrophy in models of secondary hypertension; however, it remains unclear about its effect on essential hypertension. This study is aimed at determining the beneficial role spontaneously rats (SHRs) mechanisms action. Treating with prevented SHRs. Likewise, decreasing production...
Previous study suggested that the receptor component protein (RCP), one of components calcitonin gene‐related peptide (CGRP) receptor, plays a multiple role in cellular signal transduction. The was designed to investigate whether or not RCP involved regulation caveolin‐1/extracellular signal‐regulated kinases‐1 and ‐2 (ERK1/2) pathway vascular smooth muscle cells (VSMCs) proliferation induced by static pressure. Mouse‐derived VSMCs line A10 (A10 VSMCs) served as project this experiment....