Antimicrobial effect of a novel silver-impregnated pedicle screw in rabbits.A spine implant model was designed to study the antimicrobial modified Titanium (Ti) screws with methicillin-resistant Staphylococcus aureus (MRSA) multiple surgical sites lumbar rabbit.Infection spinal is great concern. Anti-infection strategies must be tested relevant animal models that will lead appropriate clinical studies.Fourteen New Zealand white rabbits were divided into 2 groups: group 1: infected unmodified...

Bone marrow biopsy is widely used method for diagnosis, follow-up and staging of hemato-oncologic diseases. This procedure also determining the bone metastasis in patients with solid tumors. In this study, clinical, hematological, pathological features 58 metastases diagnosed by biopsies were examined retrospectivelyAmong 3345 performed our hospital between January 2006 August 2013, cases tumor metastasized to included study.Among organ carcinoma marrow, mean age was 59.9. Thirty-nine found...

Objective Dental mesenchymal stem cells (MSCs) are potential for use in tissue regeneration inflammatory diseases due to their rapid proliferating, multilineage differentiation, and strong anti-inflammatory features. In the present study, immunoregulatory glandular effects of dental follicle (DF)MSCs Sjögren’s Syndrome (SS) were investigated. Methods (DF) tissues obtained from healthy individuals during tooth extraction, digested enzymatically DFMSCs cultured until third passage. labeled...

Colorectal cancers (CRC) are one of the most common tumors that being researched for new biomarkers worldwide. In this context, studies carried out to estimate whether various hematological parameters can be used predicting prognosis. study, our aim was evaluate relation between platelet (PLT) levels as well neutrophil-to-lymphocyte ratio (NLR), (PLT)-to-lymphocyte (PLR), and Lymphocyte-to-CRP (LCR) which easily accessible inflammatory response indicators.

Dermoid cysts are benign lesions seen in young adults. The second most common localization is the floor of mouth. They usually asymptomatic over years but can be symptomatic due to secondary changes or size. Herein, we report a case 19-year-old woman who applied emergency service with dyspnea, dysphagia and enlarging mass submental region. patient cannot entubated because pushing tongue base backward closing laryngeal view. Elective tracheostomy was performed for providing airflow during...

Nodular fasciitis is a benign, reactive, tumor-like lesion composed of fibroblasts and myofibroblasts. It typically occurs in the extremities trunk. Head neck localization 13-20%. As it grows rapidly, clinicians frequently misdiagnose as an aggressive or malignant lesion. Some lesions show moderate cellularity, mild cellular atypia, mitosis histologically causing pathologists to over-diagnose tumor. important diagnose nodular correctly avoid unnecessary additional surgery treatment. We...

INTRoduCTIoNDermatofibroma (DF) is a benign fibrohistiocytic tumor usually seen in women and located the limbs.Dermatofibrosarcoma protuberans (DFSP) with intermediate malignant potential.The recurrence rate metastatic potential higher DFSP.Due to differences treatment prognosis, it important diagnose these lesions correctly.In practice, CD34 Factor XIIIa markers are often used distinguish DP from DFSP (1, 2).Some studies have reported focal positivity DF, especially peripheral region of...

Abstract Background This study investigated the effect of matrix metalloproteinase ( MMP )‐9 and 10, stress hyperglycaemia on necessity emergency renal replacement therapy RRT ) mortality in nondiabetic geriatric patients with acute kidney injury AKI ). Materials Methods The present observational longitudinal included 101 (age >65 years) . serum levels ‐9 ‐10 were evaluated these patients. Serum glucose level >140 mg/dL at time admission was accepted as hyperglycaemia. Results average...

Background and Objectives: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by the autoantibody-mediated destruction of platelets. The treatment ITP aims to maintain a sufficient platelet count prevent bleeding. First-line options include corticosteroids intravenous immunoglobulin (IVIg), while second-line treatments splenectomy, rituximab other immunosuppressive agents, thrombopoietin (TPO) receptor agonists. This study discuss methods results from 100 patients with at...

The prognostic significance of angiogenesis has been demonstrated in various types cancer. However, colorectal cancer (CRC), there are conflicting results regarding the relationship between and clinical-histopathological factors. Mast cells immune system found inflammatory microenvironment; their role carcinogenesis prognosis remains unclear although they considered to cause development progression. present study aims evaluate mast cell accumulation assessed by microvessel density (MVD)...

Methotrexate is a cytotoxic agent used in leukemia, and several other cancer types at lower doses auto-inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis psoriasis. Macrolide antibiotics are effective against gram-positive Gram-negative bacteria. They have anti-inflammatory activities well. Clarithromycin macrolide with activity through blockage of the p38 MAPK signal cascade, which involved methotrexate-induced pulmonary toxicity.In this study, efficacy...

Gleason scoring is the grading system which strongly predicts prognosis of prostate cancer. However, even being one most commonly used systems, presence different interobserver agreement rates push uropathologists update definitons patterns. In this study, we aimed to determine variability among 7 general pathologists, and expert uropathologist from 6 centers.A set 50 Hematoxylin & Eosin stained slides 41 patients diagnosed as cancer were revised by 8 pathologists. The pathologists also...

Cystic hygromas/lymphangiomas are extremely rare malformations in adults. They usually seen infants and children under 2 years of age. En bloc resection is difficult due to the adhesive characteristics tumors. Inadequate surgical intervention often leads recurrent disease. We report herein case a cystic hygroma/lymphangioma that presented as an uncommon mass on cervical region adult, together with its histopathological, radiologic, operative features.

Langerhans cell histiocytosis (LCH) is a rare and heterogeneous disease caused by clonal proliferation of cells which are one the members monocyte macrophage system. The incidence LCH in adults extremely rare: 1–2/million. Symptoms include dermatological lesions, typically seen as seborrheic-like dermatitis scalp, addition to petechial lesions intertriginous areas. Perianal ulcerative an type skin manifestation. Herein, we report case perianal presentation adult patient.

Deferasirox is an iron chelator agent used in the treatment of diseases with overload, such as thalassemia and myelodysplastic syndrome. Although majority adverse reactions deferasirox involve gastrointestinal symptoms increase serum creatinine transaminases, skin rashes, maculopapular urticarial eruptions, have also been reported. This study reports a case syndrome vasculitis due to therapy. Drug eruption was confirmed by means challenge test, together histopathological clinical findings....

This study was designed to determine the characteristic features of upper urinary system urothelial carcinomas (UUSUCs) and evaluate clinicopathological parameters associated with prognosis.Materials methods: A total 74 cases UUSUC were included, from three different centers. Demographic data histopathological such as tumor localization, concomitant in system, distant metastasis overall survival disease-free obtained hospital records evaluated retrospectively. Histopathologic prognostic...

There is a growing debate on the existence of G-spot. G-spot amplification by various surgical interventions has become mainstream for esthetic vaginal surgery despite lack conclusive proof The aim this study was to search histologic evidence in regions so-called hyperintense focus (HF) (considered as G-spot) using magnetic resonance imaging (MRI) mapping and biopsied tissues.Fifteen patients who had grade 2 or higher anterior compartment defects were enrolled study. All subjected MRI. When...

Background: PSA levels between 0-4 ng/ml is generally accepted as normal range, there no world widely cut-off value. level most commonly used for determining patients to whom needle biopsy should be performed. Authors aimed investigate the relationship preoperative and histopathological features.Methods: Ninety prostatic adenocarcinoma cases diagnosed January 2013 2018 treated by RP were included. Patients had measurement of before operation excluded from study. grouped according low-risk...