A5101459919- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- CAR-T cell therapy research
- Nuclear Receptors and Signaling
- 3D IC and TSV technologies
- Neuroscience and Neuropharmacology Research
- Advanced Proteomics Techniques and Applications
- Eicosanoids and Hypertension Pharmacology
- Copper Interconnects and Reliability
- Lymphoma Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- NF-κB Signaling Pathways
- Psoriasis: Treatment and Pathogenesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- IL-33, ST2, and ILC Pathways
- Olfactory and Sensory Function Studies
- Electronic Packaging and Soldering Technologies
- TGF-β signaling in diseases
- Cancer, Hypoxia, and Metabolism
- Acute Myeloid Leukemia Research
Qinghai University
2024
The University of Texas MD Anderson Cancer Center
2012-2020
Peking University
2019
Peking University Third Hospital
2019
Center for Special Minimally Invasive and Robotic Surgery
2018
Robotic Technology (United States)
2018
Robotic Research (United States)
2018
Liuyang City Maternal and Child Health Hospital
2018
Azur Space Solar Power
2018
Tsinghua University
2014-2018
T follicular helper cells (Tfh cells) play a pivotal role in germinal center reactions, which require B cell lymphoma 6 (Bcl6) transcription factor. To analyze their relationships with other effector lineages and stability vivo, we developed analyzed new Bcl6 reporter mouse alone or together lineage systems. Assisted genome-wide transcriptome analysis, show substantial plasticity of differentiation the early phase immune response. At this stage, CXCR5 appears to be expressed Bcl6-independent...
CD8+ T cells can be polarized into IL-9–secreting (Tc9) cells. We previously showed that adoptive therapy using tumor-specific Tc9 generated stronger antitumor responses in mouse melanoma than classical Tc1 To understand why exert responses, we used gene profiling to compare and expressed different levels of cholesterol synthesis efflux genes possessed significantly lower content Unique Tc9, but not other or CD4+ cell subsets, manipulating polarizing affected IL-9 expression differentiation...
Abstract IL-9 is a proallergic cytokine produced by newly proposed Th cell subset, Th9. Th9 cells can be generated treatment of naive T with TGF-β and IL-4 in vitro. However, it still not clear how signaling regulates differentiation. In this study, we demonstrate that Smad2 Smad4, two transcriptional factors activated signaling, are required for differentiation Deficiency or Smad4 resulted impaired expression, which was coincident enrichment repressive chromatin modification histone H3 K27...
Foxp3-expressing regulatory T (Treg) cells are essential for immune tolerance; however, the molecular mechanisms underlying Treg cell expansion and function still not well understood. SUMOylation is a protein post-translational modification characterized by covalent attachment of SUMO moieties to lysines. UBC9 only E2 conjugating enzyme involved in this process, loss completely abolishes pathway. Here, we report that selective deletion Ubc9 within lineage results fatal early-onset...
Abstract Nur77, an orphan nuclear receptor, plays a key role in apoptosis T cells. In cancer cell lines, Nur77 can induce through the intrinsic apoptotic pathway, but mechanism by which kills cells remains controversial. this study, we provide biochemical, pharmacological, and genetic evidence demonstrating that induces activation of pathway We also show is physiological substrate MEK-ERK-RSK cascade. Specifically, demonstrate RSK phosphorylates at serine 354 modulates export intracellular...
Abstract Gaseous formaldehyde is an organic small molecule formed in the early stages of earth’s evolution. Although toxic high concentrations, plays important role cellular metabolism and, unexpectedly, found even healthy brain. However, its pathophysiological functions brain are unknown. Here, we report that under physiological conditions, spatial learning activity elicits rapid generation from mitochondrial sarcosine dehydrogenase (SARDH). We find elevated levels facilitate memory...
The molecular mechanisms that govern differential T cell development into pro-inflammatory Th17 vs. regulatory (Treg) cells remain unclear. Here, we show selective deletion of CREB in or impaired differentiation vitro and vivo, led to resistance autoimmune diseases. Mechanistically, CREB, activated by CD3-PKC-ϴ signaling, plays a key role regulating differentiation, at least part through directly binding the Il17-Il17f gene locus. Unexpectedly, although dispensable for FOXP3 expression...
Abstract SUMOylation is an important posttranslational modification that regulates protein function in diverse biological processes. However, its role early T cell development has not been genetically studied. UBC9 the only E2 enzyme for all SUMOylation. In this study, by selectively deleting Ubc9 gene cells, we have investigated functional roles of development. Loss results a significant reduction CD4 and CD8 single-positive lymphocytes both thymus periphery. Ubc9-deficient cells exhibit...
Abstract Chemotherapy is the primary treatment for patients with acute myeloid leukemia (AML). In addition to factors such as patient age, physical condition, and choice of medication, we have noticed that environmental altitude may also a significant impact on post-chemotherapy bone marrow suppression in AML clinical practice. The results indicate there are differences proteomics two groups during period after chemotherapy. Differentially expressed proteins primarily located cytoplasm,...