A5042821330- Chemistry and Chemical Engineering
- Computational Drug Discovery Methods
- Biochemical and Molecular Research
- Machine Learning in Materials Science
- Enzyme Catalysis and Immobilization
- Amino Acid Enzymes and Metabolism
- HIV/AIDS drug development and treatment
- Hybrid Renewable Energy Systems
- Sustainable Supply Chain Management
- Metal-Catalyzed Oxygenation Mechanisms
- Anaerobic Digestion and Biogas Production
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microbial Fuel Cells and Bioremediation
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Process Optimization and Integration
- Enzyme-mediated dye degradation
Merck & Co., Inc., Rahway, NJ, USA (United States)
2019-2024
Merck Institute for Science Education
2021
Merck (Japan)
2021
Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing, offering levels of selectivity and tunability that can dramatically improve chemical synthesis. Combining enzymatic into multistep biocatalytic cascades brings additional benefits. Cascades avoid the waste generated by purification intermediates. They also allow be linked together overcome an unfavorable equilibrium or accumulation unstable inhibitory We report in vitro cascade synthesis investigational HIV...
Sustainable small molecule Active Pharmaceutical Ingredient (API) manufacturing starts at the onset of route development by employing a Green-by-Design strategy. Reliable metrics are imperative for setting targets and measuring process improvements throughout cycle. This article reviews some many tools methods established to analyze assess greenness sustainability process, each which highlights different aspects efficiency, waste formation or overall environmental impact reduction. Most...
An important metric for gauging the impact that a synthetic route has on chemical resources, cost, and sustainability is process mass intensity (PMI). Calculating overall PMI or step-PMI given synthesis from description more common across pharmaceutical industry, especially in chemistry departments. As with other companies, our company established strong track record of delivering Corporate Sustainability goals, being recognized eight EPA Green Chemistry Challenge Awards last 15 years, we...
Manganese(<sc>iii</sc>) acetate activates galactose oxidase (GOase), a Cu-dependent metalloenzyme that catalyzes the oxidation of alcohols to aldehydes.
Biocatalytic oxidations have the potential to address many synthetic challenges, enabling selective synthesis of chiral intermediates, such as carbonyl compounds, alcohols, or amines. The use oxygen-dependent enzymes can dramatically reduce environmental footprint redox transformations at manufacturing scale. Here, part biocatalytic cascade anti-HIV investigational drug islatravir (1), we describe development an aerobic oxidation process delivering (R)-ethynylglyceraldehyde-3-phosphate (3)...
Biocatalytic oxidations have the potential to address many synthetic chemistry challenges, enabling selective synthesis of chiral intermediates such as carbonyl compounds, alcohols, or amines. The use oxygen-dependent enzymes can dramatically reduce environmental footprint redox transformations at manufacturing scale. Here, part biocatalytic cascade an anti-HIV investigational drug islatravir 1, we describe development aerobic oxidation process delivering (R)-ethynylglyceraldehyde...
The identification, quantification, understanding, and control of impurities in starting materials, intermediates, substances are crucial during the evaluation new molecular entities clinical development pharmaceutical industry. Through process characterization islatravir (MK-8591), two from regulatory material, TMS-Triol, were discovered a late stage that persisted product. However, they not detectable by gas chromatography (GC) method used. This paper describes use orthogonal analytical...
An important metric for gauging the impact a synthetic route has on chemical resources, cost, and sustainability is process mass intensity (PMI). Calculating overall PMI or step given synthesis from description more common across pharmaceutical industry, especially in chemistry departments. Our company established strong track record of delivering our Corporate Sustainability goals, being recognized with eight EPA Green Chemistry Challenge Awards last 15 years we show how these routes help...
An important metric for gauging the impact a synthetic route has on chemical resources, cost, and sustainability is process mass intensity (PMI). Calculating overall PMI or step given synthesis from description more common across industry. Our company established strong track record of delivering our Corporate Sustainability goals, being recognized with seven EPA Green Chemistry Challenge Awards in last 15 years. While green chemistry principles help optimizing developing sustainable...
An important metric for gauging the impact a synthetic route has on chemical resources, cost, and sustainability is process mass intensity (PMI). Calculating overall PMI or step given synthesis from description more common across industry. Our company established strong track record of delivering our Corporate Sustainability goals, being recognized with seven EPA Green Chemistry Challenge Awards in last 15 years. While green chemistry principles help optimizing developing sustainable...