A5102748604- Supramolecular Self-Assembly in Materials
- Advanced Cellulose Research Studies
- Polydiacetylene-based materials and applications
- Lignin and Wood Chemistry
- Lipid Membrane Structure and Behavior
- Biofuel production and bioconversion
- Advanced Polymer Synthesis and Characterization
- Wood Treatment and Properties
- Chemical Synthesis and Analysis
- Block Copolymer Self-Assembly
- Layered Double Hydroxides Synthesis and Applications
- RNA Interference and Gene Delivery
- Carbohydrate Chemistry and Synthesis
- Surfactants and Colloidal Systems
- Magnesium Oxide Properties and Applications
- Antimicrobial Peptides and Activities
- Advanced biosensing and bioanalysis techniques
- Enzyme-mediated dye degradation
- Luminescence and Fluorescent Materials
- Protein Structure and Dynamics
- Natural Fiber Reinforced Composites
- Boron Compounds in Chemistry
- Polymer Surface Interaction Studies
- Bamboo properties and applications
- Wood and Agarwood Research
Aalto University
2011-2020
Espoo Music Institute
2017
University of Reading
2016
Abstract Composite fibres that contain cellulose and lignin were produced from ionic liquid solutions by dry‐jet wet spinning. Eucalyptus dissolving pulp organosolv/kraft blends in different ratios dissolved the 1,5‐diazabicyclo[4.3.0]non‐5‐enium acetate to prepare a spinning dope which composite spun successfully. The had high strength with slightly decreasing values for an increasing share of lignin, is because reduction crystallinity. total orientation SEM images show morphological...
This is the first experimental evidence that both self-assembly and surface activity are common features of all water-soluble boron cluster compounds. The solution behavior anionic polyhedral boranes (sodium decaborate, sodium dodecaborate, mercaptododecaborate), carboranes (potassium 1-carba-dodecaborate), metallacarboranes {sodium [cobalt bis(1,2-dicarbollide)]} was extensively studied, it evident clusters form multimolecular aggregates in water. However, mechanism aggregation dependent on...
TEMPO-mediated oxidation of microgranular cellulose results in particles three different length scales: nanocrystals as well small (μm) and larger (tens μm) porous with high charge density.
Cellulose nanocrystals (CNCs) are topical in materials science but their full potential is yet to be fulfilled because of bottlenecks the production: process consumes huge amounts water, recycling strong acid catalyst difficult, and purification steps cumbersome, particularly with lengthy dialysis. Production CNCs HCl vapour overcomes many these difficulties dispersion from already hydrolysed fibre matrix a formidable challenge. This study fundamental effort explore very basic means...
The self-assembled structure of toll-like receptor agonist lipopeptides containing the CSK4 peptide sequence is examined in aqueous solution.
Abstract The self-assembly of two derivatives KLVFF, a fragment Aβ(16–20) the amyloid beta (Aβ) peptide, is investigated and recovery viability neuroblastoma cells exposed to Aβ (1–42) observed at sub-stoichiometric peptide concentrations. Fluorescence assays show that NH 2 -KLVFF-CONH undergoes hydrophobic collapse formation same critical aggregation concentration ( cac ). In contrast, -K(Boc)LVFF-CONH low concentration, followed by higher . These findings are supported β-sheet features...
The spontaneous assembly of a peptide bolaamphiphile in water, namely, RFL4FR (R, arginine; F, phenylalanine; L, leucine) is investigated, along with its novel properties surface modification and usage as substrates for cell culture. self-assembles into nanosheets through lateral association the backbone. L4 sequence located within core nanosheets, whereas R moieties are exposed to water at nanosheets. Kinetic assays indicate that self-assembly driven by remarkable two-step process, where...
Amphiphilicity is the most critical parameter in self-assembly of surfactant-like peptides (SLPs), regulating way by which hydrophobic attraction holds together. Its effects go beyond supramolecular assembly and may also trigger different cell responses bioactive peptide-based nanostructures. Herein, we investigate cellular nanostructures based on isomeric SLPs composed arginine (R) phenylalanine (F). Two amphipathic designs were studied: a diblock construct F4R4 its bolaamphiphile analog...
The bola-amphiphilic arginine-capped peptide RFL4RF self-assembles into nanotubes in aqueous solution. nanostructure and rheology are probed by situ simultaneous rheology/small-angle scattering experiments including rheo-SAXS, rheo-SANS, rheo-GISANS (SAXS: small-angle X-ray scattering, SANS: neutron GISANS: grazing incidence scattering). Nematic alignment of under shear is observed at sufficiently high rates steady either Couette or cone-and-plate geometry. extent increases with rate. A...
The self-assembly of peptide nanotubes formed by an<sc>l</sc>-glutamic acid-based bolaamphiphile is shown to proceed<italic>via</italic>a remarkable mechanism where the conformation changes from β-sheet unordered.
The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, shown to self-assemble into spherical micelles above critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl2 , contrast claims literature that required micellization.
The morphology and chemical composition of the inner bark four willow hybrids were analyzed as a step toward complete biomass valorization. consisted highly delignified bundles thick-walled sclerenchyma fibers nondelignified surrounding tissue thin-walled parenchyma cells. In comparison with wood fibers, longer, they had very narrow lumen their walls made up to eight separate layers. One fourth dry mass was formed ash acetone extractable substances. Although lignin-to-polysaccharide ratio...
A comprehensive study of the self-assembly in water a lipopeptide consisting sequence l-proline, l-arginine and l-tryptophan with hydrocarbon chain has been performed. Fluorescence assays were used to determine critical aggregation concentration. In situ small-angle X-ray scattering (SAXS) molecular dynamics simulations showed presence spherical micelles diameters around 6 nm. agreement these results, cryo-TEM images globular aggregates ranging from ≈4 nm up ≈9 Furthermore, catalytic...
Lipidation is a powerful strategy to improve the stability in vivo of peptide drugs. Attachment lipid chain hydrophilic leads amphiphilicity and potential for surfactant-like self-assembly. Here, self-assembly conformation three lipidated derivatives gastrointestinal hormone PYY3–36 examined using comprehensive range spectroscopic, scattering, electron microscopy methods compared those parent peptide. The peptides are at Ser(11), Arg(17), or Arg(23) peptide; former within β-turn domain...
Poly(N-substituted glycine) "peptoids" constitute a promising class of peptide-mimetic materials. We introduce the self-assembly lipopeptoids into spherical micelles ca. 5 nm in diameter as well larger assemblies by varying peptoid sequence design. Our results point to design rules for nanostructures, enabling creation stable, ultra-small peptidomimetic nanospheres.
The self-assembly in aqueous solution of three lipopeptides comprising a bioactive motif conjugated at the N terminus to dodecyl, tetradecyl or hexadecyl lipid chains has been examined. is peptide block YEALRVANEVTLN; C-terminal fragment lumican proteoglycan. This study was motivated by our previous studies on homologue C16-YEALRVANEVTLN, which showed aggregation into β-sheet structures above critical concentration (cac), but most remarkably, we found that these aggregates were stable...
Enzymatic modification of bleached softwood kraft fibres for improved fibre reactivity was studied at high (20% w/w) and low (1% dry matter content. The role enzyme family structure in assessed using endoglucanases from three structurally different glycoside hydrolase (GH) families (5, 7 45) with without a carbohydrate binding module (CBM). Based on the amount dissolved sugars, action consistency about sixfold higher compared to treatment consistency. GH45 endoglucanase found be most...
The self-assembly and bioactivity of a peptide amphiphile (PA) incorporating 13-residue sequence derived from the last 13 amino acids C-terminus lumican, C16-YEALRVANEVTLN, attached to hexadecyl (C16) lipid chain have been examined. Lumican is proteoglycan found in many types tissue involved collagen fibril organization. A critical aggregation concentration (cac) for PA was determined through pyrene fluorescence measurements. structure aggregates imaged using electron microscopy, twisted...
Sequence defined peptide–peptoid hybrids create new opportunities for self-assembled nano-structures.