A5015316949- RNA Research and Splicing
- Neurogenesis and neuroplasticity mechanisms
- Biochemical and Molecular Research
- Interpreting and Communication in Healthcare
- Mesenchymal stem cell research
- S100 Proteins and Annexins
- Axon Guidance and Neuronal Signaling
- Kruppel-like factors research
- Circular RNAs in diseases
- Anesthesia and Neurotoxicity Research
- Ubiquitin and proteasome pathways
- International Student and Expatriate Challenges
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Connective Tissue Growth Factor Research
- Language, Discourse, Communication Strategies
Second Affiliated Hospital of Nanjing Medical University
2018-2025
Tsinghua University
2017-2024
Tongji Hospital
2019-2024
Tongji University
2019-2024
Chinese Institute for Brain Research
2017-2020
Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal transition and cancer metastasis. Mutation ZEB1 associated with human diseases defective brain development. Here we show that downregulation Zeb1 expression in embryonic cortical neural progenitor cells (NPCs) necessary for proper neuronal differentiation migration. Overexpression during differentiation, when its normally declines, blocks NPC lineage progression disrupts multipolar-to-bipolar...
Abstract Radial glial cells (RGCs) are the neural stem (NSCs) in developing brain, capable of self-renewing and generating neurons glia order. The developmental behaviors NSCs determined by extrinsic factors from NSC niche, together with intrinsic factors. Here, we show that Cellular Communication Network 1 (CCN1), a secreted matricellular protein, is an autocrine factor derived RGCs embryonic telencephalon. Loss Ccn1 leads to accelerated lineage progression RGCs, causes premature cell cycle...
Neural stem/progenitor cells (NSPCs) undergo active proliferation and exit the cell cycle upon precise regulation to produce differentiated progenies in order. Long noncoding RNAs (lncRNAs) have emerged as critical players developmental processes of NSPCs; however, relatively few been shown regulate vivo directly. Here, we identified an NSPC expressed lncRNA Lockd (lncRNA downstream Cdkn1b) developing forebrain. Using loss function models by premature termination transcription via knockin...